Cellular Players in Skeletal Muscle Regeneration

Skeletal muscle, a tissue endowed with remarkable endogenous regeneration potential, is still under focused experimental investigation mainly due to treatment potential for muscle trauma and muscular dystrophies. Resident satellite cells with stem cell features were enthusiastically described quite a long time ago, but activation of these cells is not yet controlled by any medical interventions. However, after thorough reports of their existence, survival, activation, and differentiation there are still many questions to be answered regarding the intimate mechanism of tissue regeneration. This review delivers an up-to-date inventory of the main known key players in skeletal muscle repair, revealed by various models of tissue injuries in mechanical trauma, toxic lesions, and muscular dystrophy. A better understanding of the spatial and temporal relationships between various cell populations, with different physical or paracrine interactions and phenotype changes induced by local or systemic signalling, might lead to a more efficient approach for future therapies.

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Faculty Opinions recommendation of Low intensity exercise training improves skeletal muscle regeneration potential.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726058756.793527559 ◽

2017 ◽

Author(s):

Pura Muñoz-Cánoves

Keyword(s):

Skeletal Muscle ◽

Exercise Training ◽

Muscle Regeneration ◽

Skeletal Muscle Regeneration ◽

Regeneration Potential ◽

Low Intensity ◽

Low Intensity Exercise

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Upregulation of Sca‐1 in satellite cells during diaphragmatic skeletal muscle regeneration: Potential novel mechanism of skeletal muscle regeneration

The FASEB Journal ◽

10.1096/fasebj.24.1_supplement.824.1 ◽

2010 ◽

Vol 24 (S1) ◽

Author(s):

Bashir Mahmoud Rezk ◽

Tadashi Yoshida ◽

Laura Semprun‐Prieto ◽

Sergiy Sukhanov ◽

Patrice Delafontane

Keyword(s):

Skeletal Muscle ◽

Satellite Cells ◽

Muscle Regeneration ◽

Skeletal Muscle Regeneration ◽

Regeneration Potential

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A role for cell sex in stem cell–mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency

The Journal of Cell Biology ◽

10.1083/jcb.200612094 ◽

2007 ◽

Vol 177 (1) ◽

pp. 73-86 ◽

Cited By ~ 139

Author(s):

Bridget M. Deasy ◽

Aiping Lu ◽

Jessica C. Tebbets ◽

Joseph M. Feduska ◽

Rebecca C. Schugar ◽

...

Keyword(s):

Skeletal Muscle ◽

Stress Responses ◽

Muscle Regeneration ◽

Donor Cell ◽

Skeletal Muscle Regeneration ◽

Mdx Mice ◽

Regeneration Potential ◽

Isolation Techniques ◽

Proliferative Advantage

We have shown that muscle-derived stem cells (MDSCs) transplanted into dystrophic (mdx) mice efficiently regenerate skeletal muscle. However, MDSC populations exhibit heterogeneity in marker profiles and variability in regeneration abilities. We show here that cell sex is a variable that considerably influences MDSCs' regeneration abilities. We found that the female MDSCs (F-MDSCs) regenerated skeletal muscle more efficiently. Despite using additional isolation techniques and cell cloning, we could not obtain a male subfraction with a regeneration capacity similar to that of their female counterparts. Rather than being directly hormonal or caused by host immune response, this difference in MDSCs' regeneration potential may arise from innate sex-related differences in the cells' stress responses. In comparison with F-MDSCs, male MDSCs have increased differentiation after exposure to oxidative stress induced by hydrogen peroxide, which may lead to in vivo donor cell depletion, and a proliferative advantage for F-MDSCs that eventually increases muscle regeneration. These findings should persuade researchers to report cell sex, which is a largely unexplored variable, and consider the implications of relying on cells of one sex.

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