Faculty Opinions recommendation of Low intensity exercise training improves skeletal muscle regeneration potential.

We have shown that muscle-derived stem cells (MDSCs) transplanted into dystrophic (mdx) mice efficiently regenerate skeletal muscle. However, MDSC populations exhibit heterogeneity in marker profiles and variability in regeneration abilities. We show here that cell sex is a variable that considerably influences MDSCs' regeneration abilities. We found that the female MDSCs (F-MDSCs) regenerated skeletal muscle more efficiently. Despite using additional isolation techniques and cell cloning, we could not obtain a male subfraction with a regeneration capacity similar to that of their female counterparts. Rather than being directly hormonal or caused by host immune response, this difference in MDSCs' regeneration potential may arise from innate sex-related differences in the cells' stress responses. In comparison with F-MDSCs, male MDSCs have increased differentiation after exposure to oxidative stress induced by hydrogen peroxide, which may lead to in vivo donor cell depletion, and a proliferative advantage for F-MDSCs that eventually increases muscle regeneration. These findings should persuade researchers to report cell sex, which is a largely unexplored variable, and consider the implications of relying on cells of one sex.

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Effect of low-intensity pulsed ultrasound on skeletal muscle regeneration after cardiotoxin-induced damage in a mouse model

Physiotherapy ◽

10.1016/j.physio.2015.03.1956 ◽

2015 ◽

Vol 101 ◽

pp. e1070-e1071

Author(s):

A. Nakamura ◽

M. Sakamoto ◽

C. Moriya ◽

A. Matsunaga

Keyword(s):

Skeletal Muscle ◽

Mouse Model ◽

Muscle Regeneration ◽

Skeletal Muscle Regeneration ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

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Cellular Players in Skeletal Muscle Regeneration

BioMed Research International ◽

10.1155/2014/957014 ◽

2014 ◽

Vol 2014 ◽

pp. 1-21 ◽

Cited By ~ 69

Author(s):

Laura Cristina Ceafalan ◽

Bogdan Ovidiu Popescu ◽

Mihail Eugen Hinescu

Keyword(s):

Skeletal Muscle ◽

Tissue Regeneration ◽

Muscle Regeneration ◽

Skeletal Muscle Regeneration ◽

Mechanical Trauma ◽

Regeneration Potential ◽

Medical Interventions ◽

Muscle Trauma ◽

Temporal Relationships ◽

Long Time

Skeletal muscle, a tissue endowed with remarkable endogenous regeneration potential, is still under focused experimental investigation mainly due to treatment potential for muscle trauma and muscular dystrophies. Resident satellite cells with stem cell features were enthusiastically described quite a long time ago, but activation of these cells is not yet controlled by any medical interventions. However, after thorough reports of their existence, survival, activation, and differentiation there are still many questions to be answered regarding the intimate mechanism of tissue regeneration. This review delivers an up-to-date inventory of the main known key players in skeletal muscle repair, revealed by various models of tissue injuries in mechanical trauma, toxic lesions, and muscular dystrophy. A better understanding of the spatial and temporal relationships between various cell populations, with different physical or paracrine interactions and phenotype changes induced by local or systemic signalling, might lead to a more efficient approach for future therapies.

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Low-Intensity Exercise Improves Aerobic Exercise Capacity in Rats After Myocardial Infarction and the Possible Role of Skeletal Muscle Autophagy

American Journal of Hypertension ◽

10.1093/ajh/hpaa156 ◽

2021 ◽

Vol 34 (2) ◽

pp. 226-226

Author(s):

Li-mei Chen ◽

Wen-wen Peng ◽

Gui-qing Xu ◽

Yue Guo ◽

Ling-jie Wei ◽

...

Keyword(s):

Myocardial Infarction ◽

Skeletal Muscle ◽

Exercise Training ◽

Aerobic Exercise ◽

Exercise Capacity ◽

Sham Group ◽

Heart Weight ◽

Low Intensity ◽

Aerobic Exercise Capacity ◽

Low Intensity Exercise

Abstract Background To investigate the effects of low-intensity exercise on aerobic exercise capacity and autophagy of skeletal muscle in rats after myocardial infarction (MI) and its possible mechanisms. Methods Thirty male Sprague Dawley rats, weighing 180–200 g, were randomly divided into sham, MI, and MI with exercise training (MI + Ex) groups. MI was induced by ligation of the left anterior descending artery. One week after surgery, low-intensity exercise training was carried out on a treadmill 5 days per week for 4 weeks. Results Infarct size of MI and MI + Ex groups was 30.8 ± 5.5% and 27.6 ± 5.0% of left ventricle, respectively (P > 0.05). Heart weight and heart to body weight ratio in the MI group were significantly higher than those in the sham group (P < 0.01), and were lowered by exercise training (P < 0.01). The maximal exercise distance and duration in the MI group were lower than those in the sham group (P < 0.01), but were significantly increased by exercise training (P < 0.05). Autophagosome of the gastrocnemius was not detectable in the sham group, scattered in the MI group but clustered in the MI + Ex group. Microtubule-associated protein light chain 3 (LC3-I/II) and Beclin-1 protein levels in the gastrocnemius were similar between MI and sham groups, but were significantly higher in the MI + Ex group (P < 0.05). Conclusions Low-intensity exercise improves exercise capacity in rats after MI. The effect is associated with enhanced autophagy of the skeletal muscle.

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