Low Intensity Exercise
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Zhongmeng Lai ◽  
Weiran Shan ◽  
Jun Li ◽  
Jia Min ◽  
Xianzhang Zeng ◽  

AbstractPostoperative cognitive dysfunction (POCD) affects the outcome of millions of patients each year. Aging is a risk factor for POCD. Here, we showed that surgery induced learning and memory dysfunction in adult mice. Transplantation of feces from surgery mice but not from control mice led to learning and memory impairment in non-surgery mice. Low intensity exercise improved learning and memory in surgery mice. Exercise attenuated surgery-induced neuroinflammation and decrease of gut microbiota diversity. These exercise effects were present in non-exercise mice receiving feces from exercise mice. Exercise reduced valeric acid, a gut microbiota product, in the blood. Valeric acid worsened neuroinflammation, learning and memory in exercise mice with surgery. The downstream effects of exercise included attenuating growth factor decrease, maintaining astrocytes in the A2 phenotypical form possibly via decreasing C3 signaling and improving neuroplasticity. Similar to these results from adult mice, exercise attenuated learning and memory impairment in old mice with surgery. Old mice receiving feces from old exercise mice had better learning and memory than those receiving control old mouse feces. Surgery increased blood valeric acid. Valeric acid blocked exercise effects on learning and memory in old surgery mice. Exercise stabilized gut microbiota, reduced neuroinflammation, attenuated growth factor decrease and preserved neuroplasticity in old mice with surgery. These results provide direct evidence that gut microbiota alteration contributes to POCD development. Valeric acid is a mediator for this effect and a potential target for brain health. Low intensity exercise stabilizes gut microbiota in the presence of insult, such as surgery.

Alamgir Khan ◽  
Muhammad Zafar Iqbal Butt ◽  
Shahzaman Khan ◽  
Sobia Nazir ◽  
Ejaz Asghar ◽  

This particular research study was basically carried out for the purpose to examine the impact of low intensity exercise on two particular liver enzymes i.e. alanine transaminase (ALT) and alkaline phosphate (ALP). 20 Non sportsmen were selected as subjects of the study (n=20, age 20 to 30 years (20.95±3.79), Body Mass Index (BMI) from 18 to 30 (25.90±5.54). Similarly the subjects were divided into two groups (Experimental Group and Control Group) through the application of International Physical Activity Questionnaire (IPAQ) and measurement of Maximum Heart Rate (MHR). 12 weeks self-made low intensity exercise protocol was applied to an experimental group.  5ml blood was collected from all subjects to measure the effect of low intensity exercise on ALT and ALP. The data of pre and post-test were processed through SPSS version 24. Based on analysis and findings, the researcher concluded that in experimental group (EXG) the level of ALT and ALP was found significantly higher (p<0.05) as compared to control group (CG). Based on conclusion, it is hereby recommended by the researcher that for the purpose to promote the functional capacity of liver, low as well as moderate intensity exercise should be performed on daily basis. In addition, in this study due to lack of financial resources, two basic liver enzymes i.e.ALT and ALP were measured, therefore the other enzymes like as AST and bilirubin also need to be examined in such other research studies.

Jelena Stanisic ◽  
Goran Koricanac ◽  
Tijana Culafic ◽  
Snjezana Romic ◽  
Mojca Stojiljkovic ◽  

2021 ◽  
Vol 12 ◽  
Yuning Hou ◽  
Renyan Ma ◽  
Song Gao ◽  
Keneilwe Kenny Kaudimba ◽  
Hongmei Yan ◽  

BackgroundHyperuricemia (HUA) is a metabolic disease by purine metabolism disorders. It is a risk factor for many chronic diseases, including diabetes, hypertension, and heart disease. Studies have shown that exercise can effectively reduce serum uric acid (SUA), but the optimal exercise dose, intensity, and mode of exercise for improving HUA have not been verified in clinical studies. Therefore, this study aims to explore the effect of different exercise intensities in improving SUA of patients with HUA.Methods and AnalysisA randomized, single-blind, parallel controlled trial will be conducted in this study. 186 HUA patients who meet the inclusion criteria will be randomly divided into a 1:1:1 ratio (1): control group (2), low-intensity exercise group (brisk walking, 57-63% maximum heart rate, 150 min/week, 12 months), and (3) moderate-intensity exercise group (jogging, 64-76% maximum heart rate, 150 min/week, 12 months). The three groups of subjects will receive the same health education and prohibition of high-purine diet during the intervention period. The primary outcomes will be SUA concentration, SUA concentration change (mg/dL), SUA change rate (%), and the proportion of HUA patients. Secondary outcomes will include anthropometric parameters (body weight, waist circumference, hip circumference, BMI); physiological indicators (blood pressure, grip, vital capacity, maximum oxygen); biochemical indicators (blood lipid, blood sugar, liver enzyme, creatinine, and blood urea nitrogen). Each group of patients will go through an assessment at baseline, 3rd, 6th, and 12th months.DiscussionThis study will evaluate the effect of 12-month low-intensity exercise and moderate-intensity exercise on HUA patients. We hypothesize that both low-intensity and moderate-intensity exercise would improve HUA as compared with no-exercise control, and that moderate-intensity exercise would be more effective than low-intensity exercise in improving HUA. These results can provide a basis for the current physical activity guidelines for HUA’s healthy lifestyle management.Ethics and DisseminationThis study has been approved by the Ethical Review Committee of the Shanghai University of Sport (approval number: 102772020RT005). Informed consent will be obtained from all participants or their guardians. The authors intend to submit the study findings to peer-reviewed journals or academic conferences to be published.Clinical Trial RegistrationChinese Clinical Trial Registry, identifier ChiCTR2100042643.

2021 ◽  
Vol In Press (In Press) ◽  
Maryam Fazeli ◽  
Marziyeh Asadizaker ◽  
Simin Jahani ◽  
Elham Maraghi ◽  
Tina Vosoughi

Background: Cancer-related fatigue (CRF) during chemotherapy and after it and decreased body energy are common problems in patients that do not resolve with sleep and rest. Objectives: This study aimed to assess the effect of combination therapy of low-intensity exercise and slow stroke back massage (SSBM) on physical activity and fatigue intensity of patients undergoing chemotherapy. Methods: This clinical trial study was performed on 92 patients with cancer undergoing chemotherapy who were referred to the oncology wards of Baqhaiee-2 hospital Ahvaz-Iran (2018 - 2020). Patients were randomly divided into two groups. Intervention group patients who received three days a week for four weeks that each session 10 minutes for slow stroke back massage and 15 minutes’ low-intensity exercise. Control group patients who received usual care. Data were collected using a demographic questionnaire, Piper Fatigue Scale (PFS), and International Physical Activity Questionnaire (IPAQ) and then analyzed using SPSS software. Results: The results showed the intensity of fatigue decreased in the experimental group, and there was a statistically significant difference between the two groups (P = 0.05). The trend of physical activity increased in the experimental group; however, there was no statistically significant difference between the two groups (P = 0.68). Conclusions: The combination of low-intensity exercise intervention and slow stroke back massage had a positive effect on fatigue severity but no statistically positive effect on physical activity.

2021 ◽  
pp. 113531
Tomomi Fujimoto ◽  
Naoto Fujii ◽  
Kohei Dobashi ◽  
Yinhang Cao ◽  
Ryoko Matsutake ◽  

Amir Hossein Ahmadi Hekmatikar ◽  
Mahdieh Molanouri Shamsi ◽  
Zahra Sadat Zabhi Ashkazari ◽  
Katsuhiko Suzuki

Coronavirus (COVID-19) is a dangerous infectious disease that is easily transmitted and which is called an acute respiratory syndrome. With the spread of the coronavirus around the world and its epidemic among humans, we are losing many humans. The long process of treatment in hospitalized patients who are receiving intensive care and medication is associated with physical weakness. It has been suggested that lifelong exercise can create a safe margin for a person that allows them to avoid becoming infected with the virus. The current study was conducted to assess the effects of low-intensity exercise and breathing exercises on cardiorespiratory responses and physical status in an overweight 20-year-old woman infected with COVID-19. The patient was referred to Hazrat Ali Ibn Abitaleb Hospital in Rafsanjan. The patient had initial symptoms of coronavirus including weakness, shortness of breath, fever, and chills, and the initial tests confirmed that the person was infected with the coronavirus. Although COVID-19 reduces respiration and blood oxygen and severely reduces movement and physical activity, low-intensity rehabilitation and breathing exercises along with medication can improve blood oxygen status, resting heart rate, blood pressure, and hand power status in patients and possibly speeding up the healing process. The results of the present study show that low-intensity exercise and breathing exercises in patients with COVID-19, whose disease severity is mild to moderate, can be performed safely under the supervision of their physicians to prevent the disease process.

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1735
Kai Aoki ◽  
Takuji Suzuki ◽  
Fang Hui ◽  
Takuro Nakano ◽  
Koki Yanazawa ◽  

The effects of exercise on nutrient digestion and absorption in the intestinal tract are not well understood. A few studies have reported that exercise training increases the expression of molecules involved in carbohydrate digestion and absorption. Exercise was also shown to increase the blood concentration of glucagon-like peptide-2 (GLP-2), which regulates carbohydrate digestion and absorption in the small intestine. Therefore, we investigated the effects of exercise on the expression of molecules involved in intestinal digestion and absorption, including GLP-2. Six-week-old male mice were divided into a sedentary (SED) and low-intensity exercise (LEx) group. LEx mice were required to run on a treadmill (12.5 m/min, 1 h), whereas SED mice rested. All mice were euthanized 1 h after exercise or rest, and plasma, jejunum, ileum, and colon samples were collected, followed by analysis via IHC, EIA, and immunoblotting. The levels of plasma GLP-2 and the jejunum expression of the GLP-2 receptor, sucrase-isomaltase (SI), and glucose transporter 2 (GLUT2) were higher in LEx mice. Thus, we showed that acute low-intensity exercise affects the expression of molecules involved in intestinal carbohydrate digestion and absorption via GLP-2. Our results suggest that exercise might be beneficial for small intestine function in individuals with intestinal frailty.

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