scholarly journals Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Alter the Gut-Brain Communication

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
L. A. Ballsmider ◽  
A. C. Vaughn ◽  
M. David ◽  
A. Hajnal ◽  
P. M. Di Lorenzo ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Nucleus Tractus Solitarius ◽  
Microglia Activation ◽  
Vagal Afferents ◽  
Motor Nucleus ◽  
Fluorescent Staining ◽  
Vertical Sleeve Gastrectomy ◽  
Dorsal Motor Nucleus ◽  
Vagal Innervation

This study investigated the anatomical integrity of vagal innervation of the gastrointestinal tract following vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) operations. The retrograde tracer fast blue (FB) was injected into the stomach to label vagal neurons originating from nodose ganglion (NG) and dorsal motor nucleus of the vagus (DMV). Microglia activation was determined by quantifying changes in the fluorescent staining of hindbrain sections against an ionizing calcium adapter binding molecule 1 (Iba1). Reorganization of vagal afferents in the hindbrain was studied by fluorescent staining against isolectin 4 (IB4). The density of Iba1- and IB4-immunoreactivity was analyzed using Nikon Elements software. There was no difference in the number of FB-labeled neurons located in NG and DMV between VSG and VSG-sham rats. RYGB, but not RYGB-sham rats, showed a dramatic reduction in number of FB-labeled neurons located in the NG and DMV. VSG increased, while the RYGB operation decreased, the density of vagal afferents in the nucleus tractus solitarius (NTS). The RYGB operation, but not the VSG procedure, significantly activated microglia in the NTS and DMV. Results of this study show that the RYGB, but not the VSG procedure, triggers microglia activation in vagal structures and remodels gut-brain communication.

scholarly journals Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats

2011 ◽  
Vol 141 (3) ◽  
pp. 950-958 ◽  
Author(s):  
Adam P. Chambers ◽  
Lene Jessen ◽  
Karen K. Ryan ◽  
Stephanie Sisley ◽  
Hilary E. Wilson–Pérez ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Blood Glucose ◽  
Glucose Homeostasis ◽  
Vertical Sleeve Gastrectomy ◽  
Blood Glucose Homeostasis

Gastro-Esophageal Reflux Disease Outcomes After Vertical Sleeve Gastrectomy and Gastric Bypass

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Daniel Leslie ◽  
Eric Wise ◽  
Adam Sheka ◽  
Hisham Abdelwahab ◽  
Ryan Irey ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Reflux Disease ◽  
Vertical Sleeve Gastrectomy ◽  
Esophageal Reflux ◽  
Disease Outcomes

Distribution of vagal cardioinhibitory neurons in the medulla of the cat

1980 ◽  
Vol 238 (1) ◽  
pp. R57-R64 ◽  
Author(s):  
J. Ciriello ◽  
F. R. Calaresu
Keyword(s):  
Nucleus Tractus Solitarius ◽  
Border Region ◽  
Nucleus Ambiguus ◽  
Motor Nucleus ◽  
Dorsal Motor Nucleus ◽  
Antidromic Stimulation ◽  
Low Threshold ◽  
Vagal Bradycardia ◽  
Medullary Nuclei ◽  
Stimulation Of

Experiments were done in cats anesthetized with chloralose, paralyzed and artificially ventilated cats to obtain electrophysiological evidence on the medullary site of origin of vagal cardioinhibitory fibers. The regions of the nucleus ambiguus (AMB), dorsal motor nucleus of the vagus (DMV), nucleus tractus solitarius (NTS), and external cuneate nucleus (ECN) were systematically explored for units responding both to antidromic stimulation of the cardiac branches of the vagus (CBV) and to orthodromic stimulation of the carotid sinus and aortic depressor nerves. Eighty-six single units conforming to these criteria were found in the medulla: 30 in the AMB, 26 in the DMV, 12 in the NTS, 8 in the NTS-DMV border region, and 10 in the ECN. Antidromically evoked spikes had durations of 0.5--2.5 ms and followed stimulation frequencies of 20--500 Hz. The axons of these units conducted at velocities of 3.3--20.8 m/s. The specificity of activation of medullary units by cardioinhibitory fibers was tested in 11 units, which were found to respond consistently with an antidromic spike to stimulation of CBV but not to stimulation of the thoracic vagus. In eight spinal animals low threshold (less than 15 microA) sites eliciting vagal bradycardia were found in the same medullary nuclei where cardioinhibitory units had been located. These results indicate that vagal cardioinhibitory axons, originate in at least three medullary nuclei, the AMB, DMV, and NTS. Unit activity from the ECN may have been recorded from carioinhibitory fibers because of the short duration of the spike potentials.

Vertical Sleeve Gastrectomy Has Better Weight Evolution and Serum Concentrations of Vitamin D when Compared with Roux-Y Gastric Bypass

2020 ◽  
Vol 30 (12) ◽  
pp. 4794-4801
Author(s):  
Bruno Rodrigues ◽  
Adryana Cordeiro ◽  
Sabrina Cruz ◽  
Silvia Pereira ◽  
Carlos Saboya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Serum Concentrations ◽  
Vertical Sleeve Gastrectomy
Sign in / Sign up

Export Citation Format

Share Document