Dual-Modality Imaging of the Human Finger Joint Systems by Using Combined Multispectral Photoacoustic Computed Tomography and Ultrasound Computed Tomography

We developed a homemade dual-modality imaging system that combines multispectral photoacoustic computed tomography and ultrasound computed tomography for reconstructing the structural and functional information of human finger joint systems. The fused multispectral photoacoustic-ultrasound computed tomography (MPAUCT) system was examined by the phantom andin vivoexperimental tests. The imaging results indicate that the hard tissues such as the bones and the soft tissues including the blood vessels, the tendon, the skins, and the subcutaneous tissues in the finger joints systems can be effectively recovered by using our multimodality MPAUCT system. The developed MPAUCT system is able to provide us with more comprehensive information of the human finger joints, which shows its potential for characterization and diagnosis of bone or joint diseases.

Download Full-text

Dual-Modality Imaging of Cancer with SPECT/CT

Technology in Cancer Research & Treatment ◽

10.1177/153303460200100605 ◽

2002 ◽

Vol 1 (6) ◽

pp. 449-458 ◽

Cited By ~ 61

Author(s):

Bruce H. Hasegawa ◽

Kenneth H. Wong ◽

Koji Iwata ◽

William C. Barber ◽

Andrew B. Hwang ◽

...

Keyword(s):

Computed Tomography ◽

Em Algorithm ◽

Photon Emission ◽

Imaging Systems ◽

Patient Specific ◽

Emission Computed Tomography ◽

Functional Information ◽

Dual Modality ◽

Photon Attenuation ◽

Dual Modality Imaging

Dual-modality imaging is an in vivo diagnostic technique that obtains structural and functional information directly from patient studies in a way that cannot be achieved with separate imaging systems alone. Dual-modality imaging systems are configured by combining computed tomography (CT) with radionuclide imaging (using positron emission tomography (PET) or single-photon emission computed tomography (SPECT)) on a single gantry which allows both functional and structural imaging to be performed during a single imaging session without having the patient leave the imaging system. A SPECT/CT system developed at UCSF is being used in a study to determine if dual-modality imaging offers advantages for assessment of patients with prostate cancer using111 In-ProstaScint®, a radiolabeled antibody for the prostate-specific membrane antigen.111 In-ProstaScint® images are reconstructed using an iterative maximum-likelihood expectation-maximization (ML-EM) algorithm with correction for photon attenuation using a patient-specific map of attenuation coefficients derived from CT. The ML-EM algorithm accounts for the dual-photon nature of the111 In-labeled radionuclide, and incorporates correction for the geometric response of the radionuclide collimator. The radionuclide image then can be coregistered and overlaid in color on a grayscale CT image for improved localization of the functional information from SPECT. Radionuclide images obtained with SPECT/CT and reconstructed using ML-EM with correction for photon attenuation and collimator response improve image quality in comparison to conventional radionuclide images obtained with filtered backprojection reconstruction. These results illustrate the potential advantages of dual-modality imaging for improving the quality and the localization of radionuclide uptake for staging disease, planning treatment, and monitoring therapeutic response in patients with cancer.

Download Full-text

Dual-modality imaging system combined fast photoacoustic imaging and ultrasound imaging

10.1117/12.845463 ◽

2009 ◽

Author(s):

Liangzhong Xiang ◽

Yi Yuan

Keyword(s):

Ultrasound Imaging ◽

Imaging System ◽

Photoacoustic Imaging ◽

Dual Modality ◽

Dual Modality Imaging

Download Full-text

Reflection-Mode Ultrasound Computed Tomography Based on Wavelet Processing for High-Contrast Anatomical and Morphometric Imaging

Applied Sciences ◽

10.3390/app11209368 ◽

2021 ◽

Vol 11 (20) ◽

pp. 9368

Author(s):

Elise Doveri ◽

Laurent Sabatier ◽

Vincent Long ◽

Philippe Lasaygues

Keyword(s):

Computed Tomography ◽

Soft Tissues ◽

Ex Vivo ◽

Ultrasonic Waves ◽

Reflection Mode ◽

Coded Excitation ◽

Ultrasonic Signals ◽

Ultrasound Computed Tomography ◽

Slice Imaging ◽

Transverse Slice

Medical B-mode ultrasound is widely used for the examination of children’s limbs, including soft tissue, muscle, and bone. However, for the accurate examination of the bone only, it is often replaced by more restrictive clinical modalities. Several authors have investigated ultrasonic imaging of bone to assess cortical thickness and/or to estimate the wave velocity through the internal structure. The present work focuses on the transverse slice imaging process using reflection-mode ultrasound computed tomography (USCT). The method is valid for imaging soft tissues with similar acoustic impedances, but in the presence of bone, the higher contrasts alter the propagation of ultrasonic waves and reduce the contrast-to-noise ratio (CNR). There is a need to change the methods used for the processing of ultrasonic signals. Our group has developed a wavelet-based coded excitation (WCE) method to process information in frequency and time. The objective of this study is to use the method to improve reflection-mode USCT, at low ultrasonic intensities, to better address organ morphometry. Experimental results on a newborn arm phantom and on an ex vivo chicken drumstick are presented, and the usefulness of this WCE-mode USCT is discussed.

Download Full-text