Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone

Amiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of ventricular tachyarrhythmias making it irreplaceable in certain group of patients. We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone which resolved after stopping the medication. The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. In this case review, we discuss the hyperacute drug toxicity caused by IV amiodarone being a distinctly different entity compared to the adverse effects shown by oral amiodarone and support the suggestion that oral amiodarone can be safely administered even in patients who manifest acute hepatitis with the IV form.

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AN UNUSUAL CASE OF EXOPHTHALMOS WITH GENERAL CONNECTIVE TISSUE CHANGES

Acta Endocrinologica ◽

10.1530/acta.0.xxxiii0613 ◽

1960 ◽

Vol XXXIII (IV) ◽

pp. 613-622 ◽

Cited By ~ 2

Author(s):

B.-A. Lamberg ◽

O. Wegelius ◽

B. Kuhlbäck ◽

C. Olin-Lamberg

Keyword(s):

Renal Failure ◽

Connective Tissue ◽

Beneficial Effect ◽

Muscle Tissue ◽

Clinical Picture ◽

Unusual Case ◽

Systemic Treatment ◽

Nasal Epithelium ◽

Tissue Changes ◽

Histochemical Examination

ABSTRACT A case is described of a man of 48, who presented a history and clinical picture of a solitary thyro-hypophysial syndrome with malignant exophthalmos but in which general connective tissue changes were found on histological and histochemical examination of the retrobulbar connective tissue and muscles, of the pretibial connective and muscle tissue and the nasal epithelium. The intraocular tension was increased. In addition, renal failure developed. The use of cortisol locally in the eyes had a beneficial effect on the eye syndrome. Systemic treatment with corticotrophin and prednisolone had an evident beneficial effect on the renal condition.

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Case Review of lgG4-Related Disease Patient with Combined Tubulointerstitial Nephritis and Membranous Nephropathy Coexisting with Cholangiocarcinoma: Case Report

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.11.10685 ◽

2020 ◽

Vol 103 (11) ◽

pp. 1230-1235

Keyword(s):

Renal Failure ◽

Membranous Nephropathy ◽

Tubulointerstitial Nephritis ◽

Disease Patient ◽

Case Review ◽

Related Disease ◽

Phospholipase A2 Receptor ◽

Wide Range ◽

Serum Igg4 ◽

Secondary Membranous Nephropathy

Immunoglobulin G4-related disease (IgG4-RD) has recently been recognized as an autoimmune disorder involving multiple organs. The kidney is a represented organ with a wide range of renal manifestations. The authors report a case of an 83-year-old Thai male with combined IgG4 tubulointerstitial nephritis and membranous nephropathy coexisting with cholangiocarcinoma. The patient presented with proteinuria, acute renal failure, eosinophilia, hypocomplementemia, and high serum IgG4 concentration. The diagnosis was IgG 4-related tubulointerstitial nephritis and membranous nephropathy on renal biopsy, with negative immunohistochemistry for anti-phospholipase A2 receptor antibodies. Magnetic resonance imaging (MRI) abdomen showed two wedge shaped arterial enhancing lesions of liver. Liver biopsy revealed adenocarcinoma, compatible with cholangiocarcinoma. Proteinuria and renal failure were resolved with initial steroid treatment. Meanwhile, IgG4-related membranous nephropathy should be considered in the differential diagnosis for patients with proteinuria. Potentially, IgG4-RD may be rarely associated with carcinoma development. However, further studies are recommended to ratify and confirm the association between IgG4-RD and incidence of malignancies. Keywords: IgG4-related disease, Membranous nephropathy, Secondary membranous nephropathy, Tubulointerstitial nephritis, Cholangiocarcinoma

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Polymyxin B Nephrotoxicity and Efficacy against Nosocomial Infections Caused by Multiresistant Gram-Negative Bacteria

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.47.8.2659-2662.2003 ◽

2003 ◽

Vol 47 (8) ◽

pp. 2659-2662 ◽

Cited By ~ 114

Author(s):

John P. Ouderkirk ◽

Jill A. Nord ◽

Glenn S. Turett ◽

Jay Ward Kislak

Keyword(s):

Renal Failure ◽

Renal Function ◽

Renal Toxicity ◽

Clinical Information ◽

Polymyxin B ◽

Gram Negative Bacteria ◽

Gram Negative ◽

Length Of Treatment ◽

Baseline Renal Function ◽

Overall Mortality

ABSTRACT Reported rates of nephrotoxicity associated with the systemic use of polymyxins have varied widely. The emergence of infections due to multiresistant gram-negative bacteria has necessitated the use of systemic polymyxin B once again for the treatment of such infections. We retrospectively investigated the rate of nephrotoxicity in patients receiving polymyxin B parenterally for the treatment of infections caused by multiresistant gram-negative bacteria from October 1999 to September 2000. Demographic and clinical information was obtained for 60 patients. Outcome measures of interest were renal toxicity and clinical and microbiologic efficacy. Renal failure developed in 14% of the patients, all of whom had normal baseline renal function. Development of renal failure was independent of the daily and cumulative doses of polymyxin B and the length of treatment but was significantly associated with older age (76 versus 59 years, P = 0.02). The overall mortality was 20%, but it increased to 57% in those who developed renal failure. The organism was cleared in 88% of the patients from whom repeat specimens were obtained. The use of polymyxin B to treat multiresistant gram-negative infections was highly effective and associated with a lower rate of nephrotoxicity than previously described.

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An unusual case of bilateral macular detachment preceding renal failure

Retinal Cases & Brief Reports ◽

10.1097/icb.0000000000001147 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Carlos A. de Amorim Garcia Filho ◽

Rodrigo A. de Oliveira ◽

Rodrigo L. Meirelles ◽

Luiz H. Lima ◽

Chandrakumar Balaratnasingam ◽

...

Keyword(s):

Renal Failure ◽

Unusual Case ◽

Macular Detachment

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Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: An unusual case

Indian Journal of Critical Care Medicine ◽

10.4103/0972-5229.60176 ◽

2009 ◽

Vol 13 (4) ◽

pp. 221-223 ◽

Cited By ~ 4

Author(s):

Gunchan Paul ◽

P. Sood ◽

B. S. Paul ◽

S. Puri

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Unusual Case ◽

Pheniramine Maleate

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Management of obstructive renal failure caused by bilateral renal aspergilloma in an immunocompetent newborn

Journal of Medical Microbiology ◽

10.1099/jmm.0.012799-0 ◽

2010 ◽

Vol 59 (3) ◽

pp. 367-369 ◽

Cited By ~ 11

Author(s):

J. D. Martinez-Pajares ◽

M. C. Martinez-Ferriz ◽

D. Moreno-Perez ◽

M. Garcia-Ramirez ◽

S. Martin-Carballido ◽

...

Keyword(s):

Renal Failure ◽

Renal Function ◽

Amphotericin B ◽

Unusual Case ◽

Bladder Exstrophy ◽

Rare Condition ◽

Antifungal Drugs ◽

Fungal Colonization ◽

Premature Babies ◽

Obstructive Renal Failure

Fungal infection of the kidneys is a rare condition that has been reported in premature babies and in diabetic or immunocompromised adult patients. Candida spp. is the most frequent micro-organism involved. This paper reports a case of an immunocompetent newborn with a bladder exstrophy who suffered from an acute renal failure caused by bilateral renal aspergilloma (Aspergillus flavus). The newborn was treated with amphotericin B urinary tract irrigation through bilateral nephrostomy catheters, combined with liposomal amphotericin B and voriconazole therapy, which improved his renal function. However, due to persistent fungal colonization, a long antifungal treatment and permanent ureterostomies were necessary to deal with new episodes of ureterorenal obstruction. As of November 2009, despite the renal injuries, renal function had been conserved. The management of the mechanical obstruction and the choice of antifungal drugs are discussed in this unusual case.

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Nephrotic Syndrome Associated With Nonsteroidal Anti-inflammatory Drug Use in Two Children

PEDIATRICS ◽

10.1542/peds.85.5.844 ◽

1990 ◽

Vol 85 (5) ◽

pp. 844-847

Author(s):

Joan Robinson ◽

Peter Malleson ◽

David Lirenman ◽

James Carter

Keyword(s):

Renal Failure ◽

Nephrotic Syndrome ◽

Drug Use ◽

Renal Disease ◽

Interstitial Nephritis ◽

Renal Toxicity ◽

Plasma Creatinine ◽

Over The Counter ◽

Inflammatory Drug ◽

Anti Inflammatory

Two children with nephrotic syndrome in association with nonsteroidal anti-inflammatory drug (NSAID) use are described, and the literature concerning this association is reviewed. NSAIDs are drugs with the potential for causing significant renal toxicity including the nephrotic syndrome, interstitial nephritis, and renal failure even in children without obvious preceding renal disease. Children prescribed such drugs should be regularly monitored with urinalyses and plasma creatinine estimations. The possibility of toxicity to over-the-counter use of NSAIDs should be remembered.

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Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case

Case Reports in Endocrinology ◽

10.1155/2015/974524 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Rıfkı Üçler ◽

Murat Atmaca ◽

Ömer Candar ◽

Murat Alay ◽

Burhan Göy ◽

...

Keyword(s):

Adverse Effect ◽

Tract Infection ◽

Respiratory Tract ◽

Respiratory Tract Infection ◽

Clinical Improvement ◽

Unusual Case ◽

Antithyroid Drugs ◽

Upper Respiratory Tract ◽

Empirical Antibiotic Treatment ◽

Upper Respiratory

Agranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. We herein describe a case of a 41-year-old woman who was previously administered methimazole (MMI) for ten days and developed ATD-induced agranulocytosis and symptoms of an upper respiratory tract infection after three weeks following discontinuation of MMI treatment. A thorough hematologic and serological evaluation did not disclose an alternative cause for the agranulocytosis. After receiving empirical antibiotic treatment, she responded successfully with clinical improvement of her symptoms and resolved neutropenia on the seventh day. This case is atypical because agranulocytosis developed after discontinuation of MMI, which strengthens the importance of remaining alert for signs of agranulocytosis even after discontinuation of ATD treatment.

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The unusual case of neck lymphadenopathy - oculoglandular form of tularemia

Polski Przegląd Otorynolaryngologiczny ◽

10.5604/01.3001.0012.2885 ◽

2018 ◽

Vol 7 (2) ◽

pp. 1-5

Author(s):

Katarzyna Baranowska-Kempisty ◽

Jolanta Kluz-Zawadzka ◽

Sylwia Warzybok-Bajda ◽

Krzysztof Szuber

Keyword(s):

Adverse Effect ◽

Case Report ◽

Francisella Tularensis ◽

Unusual Case ◽

Drug Research ◽

Delayed Diagnosis ◽

Clinical Manifestations ◽

Elisa Test ◽

Gram Negative ◽

The Right

Tularemia is anthropozoonosis caused by Bacteria Francisella tularensis a gram negative, non-motile aerobic bacillus.[5][8] The bacteria is transmitted mostly by rabbits, hares, rodents and arthropods. The pathogen penetrates into an organism via damaged skin, conjunctiva or mucosa- either through inhalation or ingestion. The clinical manifestations depend on the route of acquisition. Six forms of the disease can be distinguished: ulceroglandular or glandular, oculoglandular, oropharyngeal, respiratory, typhoidal, and intestinal. [11] We present a case report of the rarest oculoglandular form of tularemia. The patient was admitted to the hospital with right pre-auricular swelling, right sided neck lymphadenopathy, conjunctivitis and a nodule of the right eyelid. After excluding more common differential diagnoses, an ELISA test was performed and Francisella tularensis antibodies were identified. Patient administered proper antibiotic therapy. Tularemia is a rarely occurring disease in Poland and is nearly never taken into consideration by otolaryngologists when diagnosing patients with neck lymphadenopathy. In clinical practice, otorhinolaryngologists should always consider this infectious zoonosis, especially the oculoglandular and oropharyngeal forms, as delayed diagnosis and treatment may causes serious health consequences in patients. In the future new drug research should be conducted because of the adverse effect of widely used medications specially for children and pregnant woman.

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