scholarly journals A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Fariba Jaffary ◽  
Mohammad Ali Nilforoushzadeh ◽  
Amirhossein Siadat ◽  
Elaheh Haftbaradaran ◽  
Nazli Ansari ◽  
...  

Background.Cutaneous leishmaniasis is an endemic disease in Iran. Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years. However, the cure rate of these agents is still not favorable. This study was carried out to compare the efficacies of intralesional glucantime with topical trichloroacetic acid 50% (TCA 50%) + glucantime and fractional carbon dioxide laser + glucantime in the treatment of cutaneous leishmaniasis.Methods.A total of 90 patients were randomly divided into three groups of 30 to be treated with intralesional injection of glucantime, a combination of topical TCA 50% and glucantime, or a combination of fractional laser and glucantime. The overall clinical improvement and changes in sizes of lesions and scars were assessed and compared among three groups.Results.The mean duration of treatment was6.1±2.1weeks in all patients (range: 2–12 weeks) and6.8±1.7,5.2±1.0, and6.3±3.0weeks in glucantime, topical TCA plus glucantime, and fractional laser plus glucantime groups, respectively (P=0.011). Complete improvement was observed in 10 (38.5%), 27 (90%), and 20 (87%) patients of glucantime, glucantime + TCA, and glucantime + laser groups, respectively (P<0.001).Conclusion.Compared to glucantime alone, the combination of intralesional glucantime and TCA 50% or fractional CO2laser had significantly higher and faster cure rate in patients with cutaneous leishmaniasis.

2014 ◽  
Vol 46 (6) ◽  
pp. 443-448 ◽  
Author(s):  
J. Hélou ◽  
I. Maatouk ◽  
G. Obeid ◽  
R. Moutran ◽  
F. Stéphan ◽  
...  

Author(s):  
Neera R. Nathan ◽  
Daniel M. O'Connor ◽  
Jonathan J. Lee ◽  
Kristine M. Cornejo ◽  
Jennifer K. Tan ◽  
...  

2019 ◽  
Vol 58 (10) ◽  
pp. 1212-1222 ◽  
Author(s):  
Rania S. Abou Eitta ◽  
Aisha A. Ismail ◽  
Rania A. Abdelmaksoud ◽  
Naser A. Ghezlan ◽  
Radwa A. Mehanna

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Vasanop Vachiramon ◽  
Pattarin Anusaksathien ◽  
Silada Kanokrungsee ◽  
Kumutnart Chanprapaph

Objective. Keratosis pilaris (KP) is a common condition which can frequently be cosmetically disturbing. Topical treatments can be used with limited efficacy. The objective of this study is to evaluate the effectiveness and safety of fractional carbon dioxide (CO2) laser for the treatment of KP.Patients and Methods. A prospective, randomized, single-blinded, intraindividual comparative study was conducted on adult patients with KP. A single session of fractional CO2laser was performed to one side of arm whereas the contralateral side served as control. Patients were scheduled for follow-up at 4 and 12 weeks after treatment. Clinical improvement was graded subjectively by blinded dermatologists. Patients rated treatment satisfaction at the end of the study.Results. Twenty patients completed the study. All patients stated that the laser treatment improved KP lesions. At 12-week follow-up, 30% of lesions on the laser-treated side had moderate to good improvement according to physicians’ global assessment (p=0.02). Keratotic papules and hyperpigmentation appeared to respond better than the erythematous component. Four patients with Fitzpatrick skin type V developed transient pigmentary alteration.Conclusions. Fractional CO2laser treatment may be offered to patients with KP. Dark-skinned patients should be treated with special caution.


Sign in / Sign up

Export Citation Format

Share Document