scholarly journals Torsade de Pointes Triggered by Early Ventricular Escape Beats in a Patient with Complete Atrioventricular Block

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Erkan Yildirim ◽  
Baris Bugan ◽  
Suat Gormel ◽  
Uygar Cagdas Yuksel ◽  
Murat Celik ◽  
...  
Keyword(s):  
Atrioventricular Block ◽  
Qt Interval ◽  
Torsade De Pointes ◽  
Polymorphic Ventricular Tachycardia ◽  
Complete Atrioventricular Block ◽  
Premature Ventricular Contractions ◽  
Qt Interval Prolongation ◽  
Qt Intervals ◽  
Prolonged Qt Interval ◽  
Complete Atrioventricular

Torsade de pointes is an uncommon and malignant form of polymorphic ventricular tachycardia and associated with a prolonged QT interval, which may be congenital or acquired. Complete atrioventricular block may cause QT interval prolongation and torsade de pointes. In this paper, we present a case with complete atrioventricular block complicated with frequent episodes of torsade de pointes triggered by early premature ventricular contractions despite normal QT intervals.

scholarly journals Electrical Injury-Induced Complete Atrioventricular Block: Is Permanent Pacemaker Required?

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Osman Beton ◽  
Tolga Han Efe ◽  
Hakki Kaya ◽  
Murat Bilgin ◽  
Lale Dinc Asarcikli ◽  
...  
Keyword(s):  
Atrioventricular Block ◽  
Low Voltage ◽  
Myocardial Necrosis ◽  
Permanent Pacemaker ◽  
Electrical Injury ◽  
Complete Atrioventricular Block ◽  
Acute Hypertension ◽  
Premature Ventricular Contractions ◽  
Conduction Disorders ◽  
Complete Atrioventricular

A considerable percentage of electrical injuries occur as a result of work activities. Electrical injury can lead to various cardiovascular disorders: acute myocardial necrosis, myocardial ischemia, heart failure, arrhythmias, hemorrhagic pericarditis, acute hypertension with peripheral vasospasm, and anomalous, nonspecific ECG alterations. Ventricular fibrillation is the most common arrhythmia resulting from electrical injury and is the leading cause of death in electrical (especially low voltage alternating current) injury cases. Asystole, premature ventricular contractions, ventricular tachycardia, conduction disorders (various degrees of heart blocks, bundle-brunch blocks), supraventricular tachycardia, and atrial fibrillation are the other arrhythmic complications of electrical injury. Complete atrioventricular block has rarely been reported and permanent pacemaker was required for the treatment in some of these cases. Herein, we present a case of reversible complete atrioventricular block due to low voltage electrical injury in a young electrical technician.

scholarly journals Cellular Basis of Biventricular Hypertrophy and Arrhythmogenesis in Dogs With Chronic Complete Atrioventricular Block and Acquired Torsade de Pointes

Circulation ◽  
1998 ◽  
Vol 98 (11) ◽  
pp. 1136-1147 ◽  
Author(s):  
Paul G. A. Volders ◽  
Karin R. Sipido ◽  
Marc A. Vos ◽  
Attila Kulcsár ◽  
S. Cora Verduyn ◽  
...  
Keyword(s):  
Atrioventricular Block ◽  
Torsade De Pointes ◽  
Complete Atrioventricular Block ◽  
Cellular Basis ◽  
Complete Atrioventricular

scholarly journals The QT long syndrome: clinical and diagnostic aspect

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Constantin Martiniuc ◽  
◽  
Serghei Pisarenco ◽  
Iurie Simionica ◽  
◽  
...  
Keyword(s):  
Qt Interval ◽  
Torsade De Pointes ◽  
Qt Prolongation ◽  
Current Data ◽  
Polymorphic Ventricular Tachycardia ◽  
Interval Prolongation ◽  
Qt Interval Prolongation ◽  
Increased Risk ◽  
Wide Range ◽  
Life Threatening

QT interval prolongation is a predictor of the life-threatening cardiac arrhythmias — polymorphic ventricular tachycardia (torsade de pointes). Long QT syndrome may be congenital or acquired. It is known that a wide range of both antiarrhythmic and non-cardiac medications might lead to QT interval prolongation. List of drugs that cause QT prolongation is constantly growing and being updated. The review contains current data on the clinical significance of the control of QT interval duration within drug therapy. Clinical conditions associated with an increased risk of QT interval prolongation are described. Drugs that can induce QT prolongation are also discussed.

scholarly journals Narrative Review: Risk-Benefit Hydroxychloroquine and Chloroquine in COVID-19

2021 ◽  
pp. 266-279
Author(s):  
Jarir At Thobari
Keyword(s):  
Qt Interval ◽  
Observational Studies ◽  
Torsade De Pointes ◽  
Conduction Block ◽  
Torsades De Pointes ◽  
Polymorphic Ventricular Tachycardia ◽  
Cardiac Events ◽  
Drug Induced ◽  
Qt Interval Prolongation ◽  
Reduction Of Mortality

Chloroquine (CQ) and Hydroxychloroquine (HCQ) are highly prescribed as medications for COVID-19 infection, although no robust or convincing data has yet been published about the efficacy in COVID-19 patients. Therefore, risk and benefit assessment are necessary for decision to prescribe these drugs in COVID-19 patient in hospitals settings. We systematically searched from MEDLINE Database which investigate the benefits and risks of HCQ and CQ among COVID-19 patients. All records were searched using the search terms Hydroxychloroquine, Chloroquine, COVID-19, and SARS-CoV-2. The selection criteria include all clinical trials and observational studies. We found 11 records about benefit and 7 records about risks on HCQ and CQ in COVID-19 patients after following inclusion and exclusion criteria. From clinical trial and observational studies have showed that HCQ is very limited benefit particularly on reduction of mortality or clinical improvement. Similarly, there were seven observational studies have estimated the cardiac event in use of HCQ or CQ in COVID-19. Even though no increase death, but these studies reported the increase risk of prolong QT-interval in high proportion and other cardiac events such as arrythmia, torsade de pointes and conduction block. We conclude that the benefit effect of HCQ and CQ in COVID-19 remains very limited. However, both medications have independently shown to increase the risk in other populations for QT-interval prolongation, drug-induced torsades de pointes/TDP (a form of polymorphic ventricular tachycardia) and drug-induced other cardiac events. 

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