Malignant Transformation of Mature Cystic Teratoma Diagnosed after a 10-Year Interval

A 67-year-old uniparous woman had undergone surgery for acute perforated gastric ulcer 10 years prior to the current presentation. Although abdominal computed tomography (CT) performed at that point had revealed a mature cystic teratoma measuring 6 cm in diameter in the right ovary, it was left untreated. She visited the department of surgery at our hospital with chief complaints of appetite loss, nausea, and vomiting that had persisted for the prior two weeks. She was admitted with a diagnosis of ileus attributed to an abdominal incisional hernia. CT performed on admission revealed a tumor measuring 21 cm in diameter with mural nodules in the right ovary. Thus, surgery was performed under suspicion of malignant transformation of the previously detected ovarian mature cystic teratoma. While neither lymphadenopathy nor distant metastasis was detected by imaging studies, bilateral adnexectomy and repair of the abdominal incisional hernia were performed. Cytology of ascites was negative. The postoperative pathological diagnosis was squamous cell carcinoma arising from teratoma, and the postoperative clinical diagnosis was stage IA ovarian cancer. It was assumed that the mature cystic teratoma which had been detected in the right ovary 10 years earlier had undergone malignant transformation.

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Ovarian mature cystic teratoma with malignant transformation: two case reports

Journal of Medical Case Reports ◽

10.1186/s13256-020-02594-4 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Afsaneh Tehranian ◽

Akram Ghahghaei-Nezamabadi ◽

Akram Seifollahi ◽

Sara Kasraei ◽

Hamideh Dehghani-Nejad ◽

...

Keyword(s):

Malignant Transformation ◽

Case Reports ◽

Cystic Teratoma ◽

Good Prognosis ◽

Mature Cystic Teratoma ◽

Treatment Protocols ◽

Large Size ◽

Stage Ia ◽

Loss Of Appetite ◽

Case Number

Abstract Background Mature Cystic Teratoma (MCT) is a benign tumor that can lead to malignant transformation (MT) in 1–3% of cases. Management of MT is a big challenge for gynecologic oncologists due to the lack of specific diagnostic and treatment protocols. Case presentation We reported two Iranian cases of MT of MCT with two different stages and prognosis. Our both cases presented the same symptoms, including chronic abdominal pain and distention, loss of appetite, and weight loss. In case number 1, despite the large size of the tumor, the disease was at stage Ia and had a good prognosis; while, case number 2 was at stage IIIc of the disease with a poor prognosis. Conclusion The stage of the disease is the most important prognostic factor, and early diagnosis and treatment are very critical for better survival.

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O935 Malignant transformation of ovarian mature cystic teratoma to intestinal adenocarcinoma

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(09)61308-4 ◽

2009 ◽

Vol 107 ◽

pp. S359-S359

Author(s):

N. Thomakos ◽

A. Vlismas ◽

A. Rodolakis ◽

M. Sotiropoulou ◽

P. Drakakis ◽

...

Keyword(s):

Malignant Transformation ◽

Cystic Teratoma ◽

Mature Cystic Teratoma

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Squamous cell carcinoma in mature cystic teratoma of the ovary

Medicinski pregled ◽

10.2298/mpns1210429a ◽

2012 ◽

Vol 65 (9-10) ◽

pp. 429-431 ◽

Cited By ~ 2

Author(s):

Jelena Amidzic ◽

Matilda Djolai ◽

Mihaela Mocko-Kacanski ◽

Aleksandar Gluhovic ◽

Jelena Ilic ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Rare Complication ◽

Cystic Teratoma ◽

Internal Surface ◽

Cystic Mass ◽

Mature Cystic Teratoma ◽

Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

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Acute Abdomen due to Mutual Tangle of Two Small Paratubal Cysts

Case Reports in Obstetrics and Gynecology ◽

10.1155/2018/2351809 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4

Author(s):

Hiroharu Kobayashi ◽

Shinichi Shibuya ◽

Kentaro Iga ◽

Keiichiro Kato ◽

Airi Kato ◽

...

Keyword(s):

Acute Abdomen ◽

Histopathological Examination ◽

Lower Abdominal Pain ◽

Cystic Teratoma ◽

Cystic Mass ◽

Mature Cystic Teratoma ◽

Contrast Enhanced ◽

The Right ◽

Enhanced Computed Tomography ◽

Paratubal Cyst

A 30-year-old woman (gravida 0) visited our hospital with a complaint of right lower abdominal pain. Transvaginal ultrasonography revealed a 5-cm swollen right ovary, which was suspected to be a mature cystic teratoma. Pelvic examination revealed moderate pain. Contrast-enhanced computed tomography showed a 44-mm cystic mass containing fat and calcified material in the right pelvis. Since torsion was suspected, emergent laparoscopic surgery was performed. Intraoperative findings were a swollen right ovary without torsion or congestion. Two small pedunculated 1- and 2-cm diameter paratubal cysts that grew from almost the same place of the ampulla of the right fallopian tube were observed. The thin stalk of the 1-cm paratubal cyst was entangled around the stalk of the 2-cm paratubal cyst, with its head congested. Through a small abdominal laparoscopic incision, the tumor of the right ovary and the two paratubal cysts were excised. Histopathological examination revealed that the right ovarian tumor was a mature cystic teratoma, and the two paratubal cysts had no malignancy. This case showed that only a 2-cm tumor with congestion caused the acute abdomen.

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Mature Cystic Teratoma of the Fallopian Tube in a Postmenopausal Woman: A Case Report and Review of the Literature

Case Reports in Obstetrics and Gynecology ◽

10.1155/2015/583021 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4

Author(s):

Mustafa Erkan Sari ◽

Ozhan Ozdemir ◽

Pinar Kadirogullari ◽

Funda Arpaci Ertugrul ◽

Cemal Resat Atalay

Keyword(s):

Postmenopausal Woman ◽

Fallopian Tube ◽

Frozen Section ◽

Operative Procedure ◽

Cystic Teratoma ◽

Cystic Mass ◽

Hair Follicles ◽

Mature Cystic Teratoma ◽

Abdominal Masses ◽

The Right

Background. Mature cystic teratomas of the fallopian tube are extremely rare and only 54 cases have been reported in the literature. In this paper, we report a mature cystic teratoma of the fallopian tube in a postmenopausal woman and we report the review of literature of tubal cystic teratomas.Case. A 62-year-old, gravida 4 postmenopausal woman presented with pain in the right lower abdominal region for a long time. An 88 × 72 × 95 mm heterogeneous mass which contained calcifications and lipoid components was detected in the right adnexal region by transvaginal ultrasonogram (TV-USG). Serum tumour markers, namely, CA125, CA15-3, and CA19-9, were within normal range. A laparotomy revealed a 9 × 10 cm cystic mass within the fimbrial region in the right fallopian tube, and right salpingoopherectomy was performed consequently. Microscopic examination revealed squamous epithelium with sebaceous glands and hair follicles, and pseudostratified ciliated respiratory epithelium with cartilage and mucous glands. Because the frozen section resulted in a benign dermoid cyst, no further operative procedure was performed. The postoperative follow-up was uneventful and the patient was discharged on the second postoperative day.Conclusion. In cases of undetermined pelvic or abdominal masses, a teratoma of the fallopian tube should be considered.

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