scholarly journals Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Yalin Hu ◽  
Junling Wang ◽  
Huiyun Zhang ◽  
Hua Xie ◽  
Weiwei Song ◽  
...  
Keyword(s):  
Mast Cells ◽  
Fold Increase ◽  
Flow Cytometry Analysis ◽  
Altered Expression ◽  
House Dust Mite Allergen ◽  
Dust Mite ◽  
Enhanced Expression ◽  
Der P1 ◽  
Dust Mite Allergen

IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema. We therefore investigated the expression of IL-18, IL-18BP, and IL-18R on mast cells by using flow cytometry analysis and mouse eczema model. The results showed that plasma free IL-18 and free IL-18BP levels in eczema patients were higher than those in healthy controls. IL-18 provoked up to 3.1-fold increase in skin mast cells. IL-18 induced also an increase in IL-18BP+ mast cells, but a reduction of IL-18R+ mast cells in mouse eczema skin. It was found that house dust mite allergen Der p1 and egg allergen OVA induced upregulation of the expression of IL-18, IL-18BP, and IL-18R mRNAs in HMC-1 cells following 2 and 16 h incubation. In conclusion, correlation of IL-18 and IL-18BP in eczema plasma suggests an important balance between IL-18 and IL-18BP in eczema. The decrease in molar concentration ratio of plasma IL-18BP/IL-18 and allergen-induced upregulated expression of IL-18 and IL-18R in skin mast cells of the patients with eczema suggests that anti-IL-18 including IL-18BP therapy may be useful for the treatment of eczema.

scholarly journals Absence of seasonal variation in concentrations of the house dust mite allergen Der p1 in south Manchester homes.

Thorax ◽  
1992 ◽  
Vol 47 (11) ◽  
pp. 928-931 ◽  
Author(s):  
S Kalra ◽  
P Crank ◽  
J Hepworth ◽  
C A Pickering ◽  
A A Woodcock
Keyword(s):  
Seasonal Variation ◽  
House Dust ◽  
House Dust Mite ◽  
Mite Allergen ◽  
House Dust Mite Allergen ◽  
Dust Mite ◽  
Der P1 ◽  
Dust Mite Allergen

scholarly journals House Dust Mite Allergen Levels of Der p1 and Der f1 in Houses of Asthmatic Children

2020 ◽  
Vol 8 (4) ◽  
pp. 267-274
Author(s):  
Abbas Dabbaghzadeh ◽  
◽  
Javad Ghaffari ◽  
Mohammad Feridoni ◽  
Afrooz Alipour ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Childhood Asthma ◽  
Mite Allergen ◽  
House Dust Mites ◽  
House Dust Mite Allergen ◽  
Asthmatic Children ◽  
Dust Mite ◽  
Der P1 ◽  
Dust Mite Allergen

Background: Exposure to house dust mites is an important cause of asthma among children. The main asthma-causing mites found in homes are Dermatophagoides farinae and Dermatophagoides. pteronyssinus. Der f1 or Der p1 are allergens of the mentioned mites. This study aimed to assess the levels of Der p1, and Der f1 in the homes of families that had a case of childhood asthma in a northern city of Iran and to determine the association between indoor house environment and the level of mites allergens present there.  Objectives: This study aimed to evaluate House Dust Mite Allergen Levels of Der p1 and Der f1 in Houses of Asthmatic Children.  Methods: Dust samples were collected from bedrooms of 91 homes of families that had cases of childhood asthma. Families filled a questionnaire about demographical characteristics and the indoor condition of their living environment. The levels of Der f1 and Der p1 were measured by enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed in SPSS v. 24 and a P-value less than 0.05 was considered significant. Results: we found that Der p1 was more prevalent than Der f1 among samples. The mean concentration of Der p1 concentration was 271.35 ng/g (9 times greater than the concentration of Der f1). When the indoor environment status was evaluated, it was found that keeping pets and having old carpets are associated with Der f1 (P<0.05). However, no significant association was found between Der p1 and the indoor conditions of the home. Conclusions: Our study showed that Der p1 level is higher than Der f1 level in the houses of children with asthma. We suggest removing carpets and pets from the house. 

Detection of house dust mite allergen (Der p1) in cord blood

2002 ◽  
Vol 109 (1) ◽  
pp. S329-S329
Author(s):  
Margo M Hagendorens ◽  
Hugo P Van Bever ◽  
Joost J Weyler ◽  
Christel Mertens ◽  
CH Bridts ◽  
...  
Keyword(s):  
Cord Blood ◽  
House Dust ◽  
House Dust Mite ◽  
Mite Allergen ◽  
House Dust Mite Allergen ◽  
Dust Mite ◽  
Der P1 ◽  
Dust Mite Allergen
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