scholarly journals Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Alina Basnet ◽  
Aakriti Pandita ◽  
Joseph Fullmer ◽  
Abirami Sivapiragasam
Keyword(s):  
Squamous Cell Carcinoma ◽  
Thyroid Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Carcinoma ◽  
Papillary Thyroid Cancer ◽  
Squamous Cell ◽  
Malignant Neoplasm ◽  
Papillary Thyroid ◽  
Anaplastic Transformation

Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. Majority of the PTC carries an excellent prognosis. However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant. On the other hand, squamous cell carcinoma of the thyroid (SCT) is an unusual neoplasm thought to arise as a primary tumor or as a component of an anaplastic or undifferentiated carcinoma. We report a patient with TCV of PTC presenting years later with squamous transformation. In addition, the patient was found to have BRAF mutation. Such dedifferentiation is considered to be a rare phenomenon and has been reported only in the form of case reports in the literature. The relationship between BRAFV600E mutation and squamous cell transformation of papillary thyroid cancer is unknown at this time. Meticulous pathology is needed to identify such variants. Our patient responded to treatment with concurrent chemotherapy with carboplatin and paclitaxel along with radiation.

scholarly journals Synchronous squamous cell carcinoma and papillary thyroid carcinoma arising from the thyroglossal duct remnant: Case report and a review of the literature

2020 ◽  
Vol 8 ◽  
pp. 2050313X2091784
Author(s):  
Marco Puccini ◽  
Nicolò Roffi ◽  
Valentina Pucci ◽  
Giacomo Fiacchini ◽  
Clara Ugolini ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Event ◽  
Papillary Thyroid ◽  
Review Of The Literature ◽  
Thyroglossal Duct ◽  
Thyroglossal Duct Remnant

Squamous cell carcinoma and papillary thyroid carcinoma simultaneously spreading from the thyroglossal duct remnant (TGDR) is a very rare event. The recognition of this condition allows a correct management and treatment, offering the best chances of cure to the patient. We describe the case of a 42-year-old woman who noticed a right-sided lump in her neck. An ultrasound scan confirmed multiple clusters of enlarged lymph nodes on the right side associated to a pre-hyoidal solid nodule. The thyroid gland was normal. Fine-needle aspiration cytology on two nodes revealed distinct metastases from squamous cell carcinoma and from papillary thyroid carcinoma. A careful screening for other head and neck tumors was negative. She underwent a Sistrunk procedure, total thyroidectomy and right lateral lymphadenectomy with en bloc jugular vein resection. On histology, a 2 cm papillary and a small squamous cell carcinoma of the TGDR were documented, with nodal metastases from both primaries. We report the overall management strategy, treatment and outcome at 26-month follow-up, and a review of the literature.

Coexistence of primary squamous cell carcinoma of thyroid with classic papillary thyroid carcinoma

2008 ◽  
Vol 58 (12) ◽  
pp. 797-800 ◽  
Author(s):  
Tae Ik Eom ◽  
Bon Yong Koo ◽  
Byung Seup Kim ◽  
Kyung Ho Kang ◽  
Seung Ku Jung ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Squamous Cell Carcinoma ◽  
Papillary Thyroid

Papillary thyroid carcinoma associated to squamous cell carcinoma

2014 ◽  
Vol 61 (4) ◽  
pp. 226-228
Author(s):  
Katty Manrique Franco ◽  
Mabel Cedeño Díaz Oderay ◽  
Carmen Aragón Valera ◽  
Olga Sánchez-Vilar Burdiel ◽  
Adela Rovira Loscos
Keyword(s):  
Squamous Cell Carcinoma ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Papillary Thyroid
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