scholarly journals Microcystic/Reticular Schwannoma of the Frontal Lobe: An Unusual Occurrence

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Lauren Pearson ◽  
Erinc Akture ◽  
Julien Wonderlick ◽  
Gregory Fuller ◽  
Maryam Zenali
Keyword(s):  
Frontal Lobe ◽  
Cranial Nerves ◽  
Neck Region ◽  
Nerve Sheath Tumor ◽  
Head And Neck Region ◽  
Peripheral Nerve Sheath Tumor ◽  
Reticular Pattern ◽  
Nerve Sheath ◽  
First Case ◽  
Unusual Occurrence

Schwannoma is a benign peripheral nerve sheath tumor that typically involves cranial nerves of the head and neck region. Intraparenchymal occurrence of this tumor is uncommon. Even rarer in this site is the microcystic/reticular pattern of schwannoma. This histologic variant, first described in 2008, has a predilection for visceral organs. Herein, we report the first case of microcystic/reticular schwannoma of the frontal lobe.

scholarly journals First documented case of intracranial falcine malignant peripheral nerve sheath tumor: illustrative case

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Renato J. Galzio ◽  
Mattia Del Maestro ◽  
Diamantoula Pagkou ◽  
Massimo Caulo ◽  
Sofia Asioli ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Cranial Nerves ◽  
Illustrative Case ◽  
Nerve Sheath Tumor ◽  
Falx Cerebri ◽  
Peripheral Nerve Sheath Tumor ◽  
Documented Case ◽  
Nerve Sheath ◽  
First Case ◽  
The Right

BACKGROUND The authors reported the first documented case of intracranial extraaxial nonneurofibromatosis type 1–related nontriton malignant peripheral nerve sheath tumor (MPNST) originating from the falx cerebri. OBSERVATIONS A 34-year-old man with headache, short-term memory deficit, postural instability, and blurred vision presented with a large heterogenous contrast-enhanced intraventricular cystic lesion originating from the free margin of the falx cerebri. The patient received surgery using the right posterior interhemispheric approach. Gross total resection was performed, and the inferior border of the falx cerebri was resected. The postoperative course was uneventful. Histological examination revealed hypercellular foci of neoplastic spindle cells with hyperchromatic and wavy nuclei. Hence, a diagnosis of MPNST was made based on concomitant immunochemistry findings, including mouse double minute 2 homolog focal positivity and geographic loss of H3K27me3. The patient received adjuvant radiotherapy, and recurrence was not observed. LESSONS Intracranial MPNSTs are extremely rare tumors, typically originating from the cranial nerves in the posterior cranial fossa. An even rarer variant of these tumors, referred to as malignant intracerebral nerve sheath tumors, may directly arise from the brain parenchyma. The authors reported the first case of an intracranial MPNST originating from the dura mater of the falx cerebri, acting as an extraaxial lesion with prevalent expansion in the right ventricle.

scholarly journals An unusual giant schwannoma over face diagnosed on FNAC: a case report

2019 ◽  
Vol 5 (7) ◽  
pp. 181
Author(s):  
Minakashi Chouhan ◽  
Mukul Singh ◽  
Shweta Sushmita ◽  
Juhi Shahab ◽  
Rashmi Arora
Keyword(s):  
Neck Region ◽  
Posterior Mediastinum ◽  
Nerve Sheath Tumor ◽  
Facial Deformity ◽  
Head And Neck Region ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Giant Schwannoma ◽  
S 100 ◽  
Slow Growing

<p>Schwannoma is a slow growing benign peripheral nerve sheath tumor arising from schwann cells. It is also known as neurilemmoma. Although it is common in the head and neck region, it rarely exceeds 10 cm in size. Usually Schwannomas are not larger than 5 to 6 cm in diameter. Large tumors are uncommon and are found in posterior mediastinum or retroperitoneum. We are presenting an unusual giant cell schwannoma over face (cheek) measuring 12×10 cms in size which caused facial deformity to the patient. The tumor was diagnosed on FNAC where cell block was prepared and IHC was done which showed S-100 positivity. This size schwannoma over cheek site has not been reported in the literature as far our knowledge. Therefore this case is unique for its size over face.</p>

scholarly journals Glioblastoma of the cerebellopontine angle and internal auditory canal mimicking a peripheral nerve sheath tumor: case report

2019 ◽  
Vol 131 (6) ◽  
pp. 1835-1839 ◽  
Author(s):  
Hirokazu Takami ◽  
Christoph M. Prummer ◽  
Christopher S. Graffeo ◽  
Maria Peris-Celda ◽  
Caterina Giannini ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Cerebellopontine Angle ◽  
Frozen Section ◽  
Cranial Nerves ◽  
Internal Auditory Canal ◽  
Molecular Testing ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
First Case

Glioblastoma (GBM) of the internal auditory canal (IAC) is exceedingly rare, with only 3 prior cases reported in the literature. The authors present the fourth case of cerebellopontine angle (CPA) and IAC GBM, and the first in which the lesion mimicked a vestibular schwannoma (VS) early in its natural history. A 55-year-old man presented with tinnitus, hearing loss, and imbalance. MRI identified a left IAC/CPA lesion measuring 8 mm, most consistent with a benign VS. Over the subsequent 4 months he developed facial weakness. The tumor grew remarkably to 24 mm and surgery was recommended; the main preoperative diagnosis was malignant peripheral nerve sheath tumor (MPNST). Resection proceeded via a translabyrinthine approach with resection of cranial nerves VII and VIII, followed by facial-hypoglossal nerve anastomosis. Intraoperative frozen section suggested malignant spindle cell neoplasm, but final histopathological and molecular testing confirmed the lesion to be a GBM. The authors report the first case in which absence of any brainstem interface effectively excluded a primary parenchymal tumor, in particular GBM, from the differential diagnosis. Given the dramatic differences in treatment and prognoses between malignant glioma and MPNST, this case emphasizes the importance of surgical intervention on an aggressively growing lesion, which provides both the best probability of local control and the critical tissue diagnosis.

scholarly journals Intra-Cranial Malignant Peripheral Nerve Sheath Tumor of Olfactory Nerve: A Case Report and Review of Literature

2018 ◽  
Vol 32 (3) ◽  
pp. 469-472
Author(s):  
Varun Aggarwal ◽  
Amit Narang ◽  
Chandni Maheshwari ◽  
Divya Kavita
Keyword(s):  
Peripheral Nerve ◽  
De Novo ◽  
Cranial Nerves ◽  
Olfactory Nerve ◽  
Prior History ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
First Case

Abstract Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are one of the very rare high grade malignancies usually affecting extremities or trunk. Incidence is 1/Lac. Intracranial MPNSTs are even rarer, schwannomatous and commonly affecting cranial nerves VIII &VII). Intra-cranial MPNSTs are usually sporadic, arising de novo. The second most common mode of origin is from malignant transformation from pre-existing schwannomas or neurofibroma. We present an extremely rare and probably the first case of intra-cranial malignant peripheral nerve sheath tumor of the olfactory nerve in a non neurofibrosis patient with no prior history of irradiation.

Recurring Intracranial Malignant Peripheral Nerve Sheath Tumor: Case Report and Systematic Review of the Literature

Neurosurgery ◽  
2011 ◽  
Vol 68 (4) ◽  
pp. E1152-E1159 ◽  
Author(s):  
Pepijn van den Munckhof ◽  
Menno R. Germans ◽  
Antoinette Y. N. Schouten-van Meeteren ◽  
Foppe Oldenburger ◽  
Dirk Troost ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Presentation ◽  
Cranial Nerves ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Nerve Sheath Tumor ◽  
Review Of The Literature ◽  
En Bloc ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath

Abstract BACKGROUND AND IMPORTANCE: To report the clinical presentation and management of an intracranial frontoparietal malignant peripheral nerve sheath tumor (MPNST) and its recurrence in a 6-year-old girl, along with a systematic review of the literature. CLINICAL PRESENTATION: A previously healthy 6-year-old girl presented with severe signs of increased intracranial pressure. Magnetic resonance imaging (MRI) revealed a large heterogeneously enhancing mass at the right frontoparietal convexity. The tumor was completely removed, the histological diagnosis was MPNST, and the patient underwent adjuvant radio- and chemotherapy. Fifteen months later, MRI revealed a small local recurrence. After upfront chemotherapy, the recurrence was removed in a radical, ie, true oncological, neuronavigationally guided, en bloc resection, including approximately 1 cm surrounding gray and white matter and overlying dura mater. Neuropathological examination revealed tumor-free margins. The patient again received adjuvant chemotherapy. Four years after diagnosis and 20 months after cessation of adjuvant therapy, there are no signs of tumor recurrence. The literature search resulted in 17 cases of intracranial MPNSTs not associated with cranial nerves. Despite macroscopically complete resection in many cases and adjuvant radio- and chemotherapy, overall survival was poor, with only 5 patients still alive upon publication (including the current patient). CONCLUSION: Intracranial MPNSTs not associated with cranial nerves are extremely rare and highly malignant tumors with poor overall survival, probably because of infiltrating growth into surrounding brain tissue. We therefore advocate consideration of nonconventional true oncological en bloc resection when approaching this rare tumor or its recurrence.

Low-grade malignant peripheral nerve sheath tumor: a report of the first case in the breast and literature review

Apmis ◽  
2016 ◽  
Vol 124 (5) ◽  
pp. 428-430 ◽  
Author(s):  
Jasmina Redzepagic ◽  
Faruk Skenderi ◽  
Jasmina Bajrovic ◽  
Vanesa Beslagic ◽  
Nermina Ibisevic ◽  
...  
Keyword(s):  
Literature Review ◽  
Peripheral Nerve ◽  
Low Grade ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
First Case

scholarly journals Benign schwannoma of the maxillary antrum

2016 ◽  
Vol 10 (02) ◽  
pp. 281-285 ◽  
Author(s):  
Oshin Hegde ◽  
Dinkar Desai ◽  
Gowri P. Bhandarkar ◽  
Tony Paul
Keyword(s):  
Rare Case ◽  
Clinical Presentation ◽  
Maxillary Antrum ◽  
Nasal Bone ◽  
Neck Region ◽  
Cell Tumor ◽  
Nerve Sheath Tumor ◽  
Head And Neck Region ◽  
Benign Schwannoma ◽  
Nerve Sheath

ABSTRACTSchwannoma also known commonly as neurilemmoma and schwann cell tumor is a benign nerve sheath tumor. About 1/3rd cases of schwannoma arise from the head and neck region but rarely from the nasal and paranasal sinuses. The recurrence rate in these cases has reported to be very rare. We report a rare case of schwannoma in a 60-year-old woman arising from the maxillary sinus further eroding the orbital floor and nasal bone. We have also described the clinical presentation, radiological, histological findings, and management of the case.

scholarly journals Retroperitoneal Malignant Peripheral Nerve Sheath Tumor Replacing an Absent Kidney in a Child

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Samin Alavi ◽  
M. T. Arzanian ◽  
Yalda Nilipour
Keyword(s):  
Peripheral Nerve ◽  
Wilms Tumor ◽  
Abdominal Mass ◽  
Soft Tissue Sarcomas ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
First Case ◽  
Genitourinary Tract Anomalies

Malignant peripheral nerve sheath tumors (MPNSTs) are nonrhabdomyosarcoma soft tissue sarcomas with rare occurrence in children specially in the retroperitoneum. We describe a young child who presented with an abdominal mass. Both ultrasound and computed tomography revealed a large right-sided abdominal mass in the anatomic place of right kidney, while no kidney or ureter was observed at that side. He underwent surgical resection of the tumor with a primary impression of Wilms tumor. To the authors’ knowledge, this is the first case of retroperitoneal malignant peripheral nerve sheath tumor and absent kidney. This case suggests the very rare probability of association of MPNSTs in children with genitourinary tract anomalies such as renal agenesis.

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