scholarly journals An unusual giant schwannoma over face diagnosed on FNAC: a case report

2019 ◽  
Vol 5 (7) ◽  
pp. 181
Author(s):  
Minakashi Chouhan ◽  
Mukul Singh ◽  
Shweta Sushmita ◽  
Juhi Shahab ◽  
Rashmi Arora
Keyword(s):  
Neck Region ◽  
Posterior Mediastinum ◽  
Nerve Sheath Tumor ◽  
Facial Deformity ◽  
Head And Neck Region ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Giant Schwannoma ◽  
S 100 ◽  
Slow Growing

<p>Schwannoma is a slow growing benign peripheral nerve sheath tumor arising from schwann cells. It is also known as neurilemmoma. Although it is common in the head and neck region, it rarely exceeds 10 cm in size. Usually Schwannomas are not larger than 5 to 6 cm in diameter. Large tumors are uncommon and are found in posterior mediastinum or retroperitoneum. We are presenting an unusual giant cell schwannoma over face (cheek) measuring 12×10 cms in size which caused facial deformity to the patient. The tumor was diagnosed on FNAC where cell block was prepared and IHC was done which showed S-100 positivity. This size schwannoma over cheek site has not been reported in the literature as far our knowledge. Therefore this case is unique for its size over face.</p>

scholarly journals Microcystic/Reticular Schwannoma of the Frontal Lobe: An Unusual Occurrence

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Lauren Pearson ◽  
Erinc Akture ◽  
Julien Wonderlick ◽  
Gregory Fuller ◽  
Maryam Zenali
Keyword(s):  
Frontal Lobe ◽  
Cranial Nerves ◽  
Neck Region ◽  
Nerve Sheath Tumor ◽  
Head And Neck Region ◽  
Peripheral Nerve Sheath Tumor ◽  
Reticular Pattern ◽  
Nerve Sheath ◽  
First Case ◽  
Unusual Occurrence

Schwannoma is a benign peripheral nerve sheath tumor that typically involves cranial nerves of the head and neck region. Intraparenchymal occurrence of this tumor is uncommon. Even rarer in this site is the microcystic/reticular pattern of schwannoma. This histologic variant, first described in 2008, has a predilection for visceral organs. Herein, we report the first case of microcystic/reticular schwannoma of the frontal lobe.

scholarly journals RARE-20. MALIGNANT PERIPHERAL NERVE SHEATH TUMOR OF A CRANIAL NERVE IN AN INFANT WITH NEUROCUTANEOUS MELANOSIS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii446-iii446
Author(s):  
Lacey Carter ◽  
Naina Gross ◽  
Rene McNall-Knapp ◽  
,and Jo Elle Peterson
Keyword(s):  
Peripheral Nerve ◽  
Cranial Nerve ◽  
Leptomeningeal Disease ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Neurocutaneous Melanosis ◽  
Spindle Cell Neoplasm ◽  
Lower Back ◽  
Nerve Sheath ◽  
S 100

Abstract At one month of age, a female presented with a giant congenital nevus along lower back and thighs and hydrocephalus. A ventriculoperitoneal shunt was placed. An MRI was done at six months, initially reported as normal. At eleven months of age, five months after original MRI, patient presented with dysconjugate gaze and lethargy. MRI showed new 3.8 x 3.7 x 3.4 cm right cerebellopontine angle mass extending into Meckel’s cave and foramen ovale along with leptomeningeal disease extending from the mass along the entire length of the spinal cord. Retrospective review of prior MRI revealed subtle leptomeningeal enhancement concerning for neurocutaneous melanosis (NCM). Given the leptomeningeal disease, family elected for open biopsy and debulking of lesion instead of aggressive resection. Histologically, the mass showed hypercellular spindle cell neoplasm with mitotic activity and necrosis mixed with remnants of normal cranial nerve. GFAP was negative, excluding a glioma. HMB-45, MITF, panmelanoma, and Melan-A were negative, excluding melanoma. A negative myogenin stain ruled out ectomesenchymoma. S-100 protein and SOX-10 positivity with variable loss of staining for trimethylation of histone H3 K27 were indicative of malignant peripheral nerve sheath tumor (MPNST). Given the course of the mass, trigeminal nerve MPNST was presumed. Given the poor prognosis of intracranial MPNST and NCM, family elected to forgo treatment and was discharged with hospice. She died 25 days after surgery. Cranial nerve MPNST is rare. MPNST in patients with NCM has not previously been reported to our knowledge.

scholarly journals A giant posterior mediastinal malignant peripheral nerve sheath tumor and benign neurofibroma in body surface: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yan Zhang ◽  
Hongfei Cai ◽  
Guangchao Lv ◽  
Yang Li
Keyword(s):  
Peripheral Nerve ◽  
Neurofibromatosis Type ◽  
Posterior Mediastinum ◽  
Pathological Examination ◽  
Nerve Sheath Tumor ◽  
Tumor Type ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Tumor ◽  
Nerve Sheath ◽  
Posterior Mediastinal

Abstract Background Neurofibromatosis comprises neurofibromatosis type 1 (NF1) and type 2 (NF2). Major tumor type of NF1 are neurofibroma recognized as benign peripheral nerve tumor, malignant peripheral nerve sheath tumor (MPNST), and glioma. Case presentation We report a woman with a special condition, whose tumors in body surfaces were benign neurofibroma and tumors in posterior mediastinum are MPNST. The chest-enhanced CT suggested a round soft tissue density in posteriormediastium. The diagnosis was established by pathology and immunohistochemistry. A single-stage thoracoscopic mediastinal mass resection was performed. The whole operation went smoothly and the CT scan of lungs did not show relapse of tumor three months later. Conclusions The appearance of neurofibroma should draw particular attention to the possibility of developing MPNST. More careful imaging examinations should be carried out, and pathological examination could diagnose it.

Submandibular neurilemmoma; a diagnostic dilemma

2004 ◽  
Vol 118 (2) ◽  
pp. 156-158 ◽  
Author(s):  
Robert Almeyda ◽  
Prasad Kothari ◽  
Ha Chau ◽  
Vincent Cumberworth
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Signs And Symptoms ◽  
Benign Neoplasms ◽  
Diagnostic Dilemma ◽  
Head And Neck Region ◽  
Neurological Signs ◽  
Nerve Sheath ◽  
Diagnostic Difficulties ◽  
Slow Growing

Neurilemmomas are slow growing, benign neoplasms of neural crest Schwann cell origin. They arise from any peripheral, spinal or cranial nerve except the olfactory and optic. Presentation is usually asymptomatic but focal neurological signs and symptoms may be associated with nerve compression. With approximately one third of all documented cases presenting in the head and neck region, we report a case of a submandibular neurilemmoma misdiagnosed pre-operatively. The diagnostic difficulties are discussed and the current literature reviewed. Thiscase highlights the importance of inclusion of nerve sheath tumours in differential diagnoses of soft tissue lesions in the head and neck.

Palatal Schwannoma: A Rare Case Report

2016 ◽  
Vol 8 (1) ◽  
pp. 29-31
Author(s):  
Nikhil Arora ◽  
PS Shahul Hameed
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Schwann Cells ◽  
Rare Case ◽  
Benign Tumor ◽  
Neck Region ◽  
Head And Neck Region ◽  
Nerve Sheath ◽  
Rare Case Report ◽  
Slow Growing

ABSTRACT Schwannoma is a benign tumor that originates from perineural Schwann cells of nerve sheath. They are solitary, wellencapsulated, slow-growing adjacent to the parental nerve but extrinsic to the nerve fascicles. Approximately 25 to 45% of all schwannomas are seen in the head and neck region and are found rarely in the oral cavity. Most of the intraoral schwannomas are located in the tongue. Palatal schwannoma is very rare as till date and only 16 cases have been reported; one such rare case we came across is reported here. How to cite this article Hameed PSS, Arora N, Malhotra V. Palatal Schwannoma: A Rare Case Report. Int J Otorhinolaryngol Clin 2016;8(1):29-31.

scholarly journals Schwannoma Located in Nasopharyngeal Region

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Fadlullah Aksoy ◽  
Alper Yenigun ◽  
Erol Senturk ◽  
Orhan Ozturan
Keyword(s):  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Neck Region ◽  
Case Presentation ◽  
Head And Neck Region ◽  
Nerve Sheath ◽  
Swallowing Difficulties ◽  
First Time ◽  
Slow Growing

Schwannoma is a tumor which has neuroectoderm origins, is hard, well-circumscribed, encapsulated, and slow growing benign cranial tumor, and may autonomously grow out of the nerve sheath of peripheral nerves. It is mostly seen in the head and neck region. In the paranasal sinus and nose areas, it is seen at a rate of 4%. The diagnosis is mostly made after histopathological examination. In this paper, a Schwannoma case observed in the nasopharyngeal region was presented in a 20-year-old female who had complaints of sleeping with open mouth, snoring, foreign body feeling in throat, and swallowing difficulties. The tumor was extracted via transoral approach. No recurrence was observed during follow-up over the next year. This case presentation is presented for the first time in the literature in English.

scholarly journals Seorang Laki-Laki dengan Tumor Mediastinum Posterior ( Malignant Peripheral Nerve Sheath Tumor )

2019 ◽  
Vol 2 (3) ◽  
pp. 82
Author(s):  
Daniel Maranatha ◽  
Shinta Karina Yuniati
Keyword(s):  
Peripheral Nerve ◽  
Malignant Tumors ◽  
Posterior Mediastinum ◽  
Surrounding Tissue ◽  
Nerve Sheath Tumor ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
S 100 ◽  
The Right

Background: Malignant tumors arising from peripheral nerves or displaying differentiation along the lines of the various elements of the nerve sheath are referred to Malignant peripheral nerve sheath tumors (MPNST) and also called malignant schwannomas or neurofibrosarcomas. The common sites of involvement are head, neck, extremities and thorax. This case was discussed due to its rare incidence, namely less than 5% of soft tissue malignant tumor. The overall five year survival rate is approximately 50% in patients with resectable tumor. Case: We report a case of MPNST arising from mediastinum, the patient was a male, 41-years-old, with chief complaint are chest pain and mass in the back. Contrast enhanced chest CT Scan showed a solid mass (10.02 × 6.97 × 10.53 cm) in the right side of the posterior mediastinum. On microscopic examination with hematoxylin eosin imunostaining, of the mass on mediastinum showed typical features of MPNST, which were positive for S-100 imunostaining. Based on convensional histopathologic and imunostaining, this case was concluded as Malignant peripheral nerve sheath tumors (MPNST). Conclusion: The treatment of chest wall MPNSTs is multimodality, including wide local excision, adjuvant radiotherapy, and chemotherapy. In our case, we performed direct excision due to the infiltrating mass to the surrounding tissue, so the prognosis for this case was good. This case indicates the role of chemotherapy in treatment of advanced MPNST. Studies shows the superiority of the doxorubicin–ifosfamide regimen. As in this case the patient showed complete respons after surgery and adjuvant chemotherapy.

scholarly journals Case report and immunohistochemical study of a malignant peripheral nerve sheath tumor in a dog

2017 ◽  
Vol 54 (4) ◽  
pp. 420
Author(s):  
Thaís De Almeida Moreira ◽  
Leandro Willian Borges ◽  
Talita Lopes Serra ◽  
Diego Petrocino Caetano ◽  
Marcelo Carrijo da Costa ◽  
...  
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Immunohistochemical Study ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
S 100

O tumor maligno da bainha do nervo periférico é raro e pouco descrito em cães. Classicamente, o termo “neurofibroma/sarcoma” é empregado quando o tumor é composto por células de Schwann e células perineurais. Neste relato são descritos os achados clínicos, histopatológicos e imuno-histoquímicos de um caso de tumor maligno da bainha do nervo periférico, provavelmente neurofibrossarcoma, localizado no subcutâneo do membro pélvico de um cão da raça Rottweiler. Os achados histopatológicos associados às observações imuno-histoquímicas contribuíram para o diagnóstico, sendo observada positividade para proteína S-100, vimentina e CD57, permitindo a diferenciação da neoplasia em questão de outros tumores malignos com características morfológicas similares.

scholarly journals Benign schwannoma of the maxillary antrum

2016 ◽  
Vol 10 (02) ◽  
pp. 281-285 ◽  
Author(s):  
Oshin Hegde ◽  
Dinkar Desai ◽  
Gowri P. Bhandarkar ◽  
Tony Paul
Keyword(s):  
Rare Case ◽  
Clinical Presentation ◽  
Maxillary Antrum ◽  
Nasal Bone ◽  
Neck Region ◽  
Cell Tumor ◽  
Nerve Sheath Tumor ◽  
Head And Neck Region ◽  
Benign Schwannoma ◽  
Nerve Sheath

ABSTRACTSchwannoma also known commonly as neurilemmoma and schwann cell tumor is a benign nerve sheath tumor. About 1/3rd cases of schwannoma arise from the head and neck region but rarely from the nasal and paranasal sinuses. The recurrence rate in these cases has reported to be very rare. We report a rare case of schwannoma in a 60-year-old woman arising from the maxillary sinus further eroding the orbital floor and nasal bone. We have also described the clinical presentation, radiological, histological findings, and management of the case.

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