scholarly journals Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Muyun Liu ◽  
Tian Xia ◽  
Di Zhang ◽  
Lianghao Hu ◽  
Zhuan Liao ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Genetic Background ◽  
Direct Sequencing ◽  
Adult Group ◽  
Male Population ◽  
Recurrent Acute Pancreatitis ◽  
Pain Attack ◽  
Male Patients

Background.The clinical pattern and genetic background of juvenile idiopathic chronic pancreatitis (ICP) are yet unclear.Methods. A retrospective study of 73 Chinese juvenile ICP patients was performed, and genetic tests were carried out to detect relevant mutations using direct sequencing technique and high-resolution melting technique. Subjects without pancreatitis served as controls.Results.The SPINK1 c.194+2T>C variant was present in 56.16% and 42.00% of juvenile and adult ICP patients, respectively (p=0.020), but was not present in any of the control subjects. Thirty-four (46.58%) of the 73 juvenile ICP patients were male, and a significantly higher ratio of male patients in the adult group was identified (46.58% versus 64.00%,p=0.022). Although most of the juvenile patients presented with abdominal pain (70/73, 95.89%), the patterns of pain attack are significantly different in patients with or without SPINK1 c.194+2T>C mutation. Patients carrying the mutation are more likely to present with recurrent acute pancreatitis (70.70%).Conclusions.The main symptom of pediatric ICP was abdominal pain. SPINK1 c.194+2T>C mutation had a higher occurrence in juvenile ICP patients than in adult group and typically presented with recurrent acute pancreatitis. There may be unidentified factors that lead to a greater incidence rate of ICP in adult male population.

scholarly journals Transduodenal Sphincteroplasty and Transampullary Septectomy for Papillary Stenosis

HPB Surgery ◽  
1996 ◽  
Vol 9 (4) ◽  
pp. 199-207 ◽  
Author(s):  
S. B. Kelly ◽  
B. J. Rowlands
Keyword(s):  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Chronic Abdominal Pain ◽  
Recurrent Acute Pancreatitis ◽  
Papillary Stenosis ◽  
Relieve Pain

Twenty patients received transduodenal sphincteroplasty and transampullary septectomy between 1987 and 1993. Seven patients had post-cholecystectomy pain which was much improved or abolished in 5 of 7 patients at a mean follow-up of 4 years and 5 months. Four of five patients with chronic pancreatitis were improved at 3 years and 2 months. Three of five patients with recurrent acute pancreatitis were improved at 4 years and 5 months. One of three patients with chronic abdominal pain of hepatobiliary origin was improved at 3 years. Transduodenal sphincteroplasty and transampullary septectomy can relieve pain in patients with post-cholecystectomy pain, recurrent acute pancreatitis, chronic pancreatitis, and chronic abdominal pain of hepatobiliary origin, presumably by improving drainage of the obstructed ducts.

scholarly journals A Case of Chronic Pancreatic Insufficiency Due to Valproic Acid in a Child

2001 ◽  
Vol 15 (2) ◽  
pp. 127-130 ◽  
Author(s):  
Mary Anne Cooper ◽  
Aubrey Groll
Keyword(s):  
Valproic Acid ◽  
Weight Loss ◽  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Pancreatic Insufficiency ◽  
Pancreatic Enzyme ◽  
Exocrine Pancreatic Insufficiency ◽  
Radiological Evaluation ◽  
Enzyme Replacement

A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis. The association with valproic acid was not recognized, and the child continued to take the drug. The patient eventually developed steatorrhea and weight loss that improved with pancreatic enzyme replacement. Radiological evaluation showed an atrophic pancreas. Without evidence of other etiological factors, valproic acid by itself appeared to be the cause of chronic pancreatitis with exocrine pancreatic insufficiency in this patient.

Genetic background is different between sentinel and recurrent acute pancreatitis

2011 ◽  
Vol 26 (6) ◽  
pp. 974-978 ◽  
Author(s):  
Atsushi Masamune ◽  
Hiroyuki Ariga ◽  
Kiyoshi Kume ◽  
Yoichi Kakuta ◽  
Kennichi Satoh ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Genetic Background ◽  
Recurrent Acute Pancreatitis

scholarly journals Physician-Controlled Wire-Guided Cannulation of the Minor Papilla

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
John T. Maple ◽  
Lilah Mansour ◽  
Tarek Ammar ◽  
Michael Ansstas ◽  
Gregory A. Coté ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Stent Placement ◽  
Case Series ◽  
Pancreatic Stent ◽  
Tertiary Referral ◽  
Recurrent Acute Pancreatitis ◽  
Minor Papilla ◽  
Safe Technique

Background. Minor papilla (MiP) cannulation is frequently performed using specialized small-caliber accessories. Outcomes data for MiP cannulation with standard-sized accessories are lacking. Methods. This is a case series describing MiP cannulation outcomes in consecutive patients treated by two endoscopists between July 2005 and November 2008 at two tertiary referral centers. MiP cannulation was attempted using a 4.4 Fr tip sphincterotome loaded with a , 260 cm hydrophilic-tip guidewire, using a wire-guided technique under physician control. Results. 25 patients were identified (14 women, mean age 45). Procedure indications included recurrent acute pancreatitis in 16 patients (64%) and chronic pancreatitis in 2 (8%), among other indications. MiP cannulation was successful in 24 patients (96%). Sphincterotomy followed by pancreatic stent placement was performed in 21 patients (84%). Mild post-ERCP pancreatitis occurred in 3 patients (12%). Conclusion. Physician-controlled wire-guided MiP cannulation using a 4.4 Fr sphincterotome and guidewire is an effective and safe technique.

Recurrent acute pancreatitis can be considered as early chronic pancreatitis: a meta-analysis of 21,186 patients

Pancreatology ◽  
2019 ◽  
Vol 19 ◽  
pp. S44
Author(s):  
Alexandra Soós ◽  
Péter Hegyi ◽  
Zsolt Szakács ◽  
Alexandra Mikó ◽  
Péter Mátrai ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Meta Analysis ◽  
Recurrent Acute Pancreatitis

scholarly journals Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Pengfan Li ◽  
Kanjun Chen ◽  
Zheng Mao ◽  
Yue Luo ◽  
Yan Xue ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Bowel Disease ◽  
Chronic Diarrhea ◽  
Inflammatory Bowel ◽  
Correlative Studies

Background/Objectives. This systematic review was conducted to investigate the association between pancreatitis and IBD. Methods. MEDLINE, Embase, and CENTRAL were systematically searched for correlative studies till 2 November 2019. RevMan5.3 was used to estimate relevance. Results. Three studies with 166008 participants were included. The risk of pancreatitis significantly increased in the patients with CD (OR, 3.40; 95% CI, 2.70-4.28; P<0.00001) and UC (OR, 2.49; 95% CI, 1.91-3.26; P<0.00001). Increased risks of CD (OR, 12.90; 95% CI, 5.15-32.50; P<0.00001) and UC (OR, 2.80; 95% CI, 1.00-7.86; P=0.05) were found in patients with chronic pancreatitis. As for patients with acute pancreatitis, there were significant association of CD (OR, 3.70; 95% CI, 1.90-7.60; P=0.0002), but were not UC. Conclusions. The evidence confirmed an association between pancreatitis and IBD. When pancreatitis patients have chronic diarrhea and mucus blood stool or IBD patients have repeated abdominal pain and weight loss, they should consult pancreatic and gastrointestinal specialists.

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