scholarly journals Association of Autoimmune Thyroid Disease with Anti-GAD Antibody ELISA Test Positivity and Risk for Insulin Deficiency in Slowly Progressive Type 1 Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Masahito Katahira ◽  
Hidetada Ogata ◽  
Takahiro Ito ◽  
Tsutomu Miwata ◽  
Megumi Goto ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Acid Decarboxylase ◽  
Insulin Deficiency ◽  
Autoimmune Thyroid ◽  
Progressive Type ◽  
Significant Difference

The presence of antiglutamic acid decarboxylase antibody (GADA) is required for the diagnosis of slowly progressive type 1 diabetes (SPT1D). We examined the factors influencing GADA determination by radioimmunoassay (GADA-RIA) and by enzyme-linked immunosorbent assay (GADA-ELISA). Sixty patients with SPT1D and 154 patients with type 2 diabetes were examined by both GADA-RIA and GADA-ELISA and for the presence of autoimmune thyroid disease (AITD). We compared the clinical characteristics of these patients based on the positivity or negativity of GADA-RIA and GADA-ELISA, and the existence or nonexistence of AITD. Thirty of 60 (50.0%) GADA-RIA-positive patients were GADA-ELISA negative, whereas none of the 154 GADA-RIA-negative patients were GADA-ELISA positive. Concomitant AITD was significantly less in patients with GADA-RIA and without GADA-ELISA and was significantly more in patients with GADA-RIA and GADA-ELISA. In GADA-RIA-positive patients, there was no significant difference in the GADA-RIA titer among the GADA-ELISA-negative patients with and without AITD, and the GADA-ELISA-positive patients without AITD; whereas the frequency of insulin deficiency was significantly higher in the patients with AITD and/or GADA-ELISA than in those without AITD and GADA-ELISA. Examination of GADA-ELISA and AITD in GADA-RIA-positive patients might be useful in predicting insulin deficiency in these patients.

scholarly journals Autoimmune Polyendocrine Syndrome 3 Onset with Severe Ketoacidosis in a 74-Year-Old Woman

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Stefano Benedini ◽  
Antonietta Tufano ◽  
Elena Passeri ◽  
Marco Mendola ◽  
Livio Luzi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Cobalamin Deficiency ◽  
Gastric Parietal Cell ◽  
Autoimmune Thyroid ◽  
Autoimmune Polyendocrine Syndrome

Type 1 diabetes mellitus (T1D), autoimmune thyroid disease, and autoimmune gastritis often occur together forming the so-called autoimmune polyendocrine syndrome type 3 (APS3). We here report a clinical case of a 74-year-old woman who presented for the first time with severe hyperglycemia and ketoacidosis diagnosed as T1D. Further clinical investigations revealed concomitant severe hypothyroidism with autoimmune thyroid disease and severe cobalamin deficiency due to chronic atrophic gastritis. The diagnosis of type 1 diabetes mellitus was confirmed by the detection of autoantibodies against glutamic acid decarboxylase 65, islet cell antibodies, and anti-insulin autoantibodies. Anti-thyroperoxidase, anti-thyroglobulin, and anti-gastric parietal cell antibodies were also clearly positive. The case emphasized that new onset diabetic ketoacidosis, hypothyroidism, and cobalamin deficiency may simultaneously occur, and one disease can mask the features of the other, thereby making diagnosis difficult. It is noteworthy that an APS3 acute episode occurred in an asymptomatic elder woman for any autoimmune diseases.

scholarly journals Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis

2016 ◽  
pp. jc.2016-2335 ◽  
Author(s):  
Berglind Jonsdottir ◽  
Christer Larsson ◽  
Annelie Carlsson ◽  
Gun Forsander ◽  
Sten Anders Ivarsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Islet Autoantibodies ◽  
Diabetes Diagnosis ◽  
Autoimmune Thyroid

scholarly journals Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

2020 ◽  
Vol 11 ◽  
pp. 204201882095832
Author(s):  
Liyan Li ◽  
Shudong Liu ◽  
Junxia Yu
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Current Knowledge ◽  
Tyrosine Phosphatase ◽  
Autoimmune Thyroid

Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.

scholarly journals Increased Prevalence of Autoimmune Thyroid Disease in Patients with Type 1 Diabetes

2000 ◽  
Vol 15 (3) ◽  
pp. 202-210 ◽  
Author(s):  
Yong Soo Park ◽  
Won Bae Kim ◽  
Tae Wha Kim ◽  
Bo Youn Cho
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

scholarly journals Incidence of Autoimmune Thyroid Disease in Patients with Type 1 Diabetes

2020 ◽  
Vol 18 (2) ◽  
pp. 251-262
Author(s):  
Edip Unal ◽  
Meliha Demiral ◽  
Murat Öcal ◽  
Birsen Baysal ◽  
Mehmet Nuri Ozbek
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid
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