Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy

Purpose.Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).Methods.24 patients with acute NAION were included. Retrobulbar hemodynamics were measured using color Doppler imaging before and 15 min after intravenous infusion of 250 cc 10% hydroxyethyl starch (HES). Peak systolic velocity (PSV), end diastolic velocity (EDV), and Pourcelot’s resistive index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs).Results.After infusion of HES blood flow velocities significantly increased in the CRA (PSV from7.53±2.33to8.32±2.51 (p<0.001); EDV from2.16±0.56to2.34±0.55 (p<0.05)) and in the PCAs (PSV from7.18±1.62to7.56±1.55 (p<0.01); EDV from2.48±0.55to2.66±0.6 cm/sec (p<0.01)). The RI of all retrobulbar vessels remained unaffected. Blood pressure and heart rate remained unchanged.Conclusions.Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients. This trial is registered withDRKS00012603.

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Retrobulbar hemodynamics in normal tension glaucoma compared to anterior ischemic optic neuropathy

Acta Ophthalmologica Scandinavica ◽

10.1111/j.1600-0420.2007.01063_3306.x ◽

2007 ◽

Vol 85 ◽

pp. 0-0

Author(s):

A REMKY ◽

M KAUP ◽

KO AREND ◽

N PLANGE

Keyword(s):

Optic Neuropathy ◽

Normal Tension Glaucoma ◽

Anterior Ischemic Optic Neuropathy ◽

Ischemic Optic Neuropathy ◽

Retrobulbar Hemodynamics

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Optic Nerve Sheath Decompression May Improve Blood Flow in Anterior Ischemic Optic Neuropathy

Ophthalmology ◽

10.1016/s0161-6420(93)31651-9 ◽

1993 ◽

Vol 100 (3) ◽

pp. 297-305 ◽

Cited By ~ 46

Author(s):

Patrick M. Flaharty ◽

Robert C. Sergott ◽

Wolfgang Lieb ◽

Thomas M. Bosley ◽

Peter J. Savino

Keyword(s):

Blood Flow ◽

Optic Nerve ◽

Optic Neuropathy ◽

Optic Nerve Sheath ◽

Anterior Ischemic Optic Neuropathy ◽

Ischemic Optic Neuropathy ◽

Nerve Sheath ◽

Improve Blood Flow

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Patterns of Cerebral Blood Flow and Systemic Hemodynamics During Arithmetic Processing

Journal of Psychophysiology ◽

10.1027/0269-8803.22.2.81 ◽

2008 ◽

Vol 22 (2) ◽

pp. 81-90 ◽

Cited By ~ 21

Author(s):

Natalie Werner ◽

Neval Kapan ◽

Gustavo A. Reyes del Paso

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Time Course ◽

Doppler Sonography ◽

Transcranial Doppler Sonography ◽

Systemic Hemodynamics ◽

Heart Period ◽

Blood Flow Velocities ◽

Flow Velocities

The present study explored modulations in cerebral blood flow and systemic hemodynamics during the execution of a mental calculation task in 41 healthy subjects. Time course and lateralization of blood flow velocities in the medial cerebral arteries of both hemispheres were assessed using functional transcranial Doppler sonography. Indices of systemic hemodynamics were obtained using continuous blood pressure recordings. Doppler sonography revealed a biphasic left dominant rise in cerebral blood flow velocities during task execution. Systemic blood pressure increased, whereas heart period, heart period variability, and baroreflex sensitivity declined. Blood pressure and heart period proved predictive of the magnitude of the cerebral blood flow response, particularly of its initial component. Various physiological mechanisms may be assumed to be involved in cardiovascular adjustment to cognitive demands. While specific contributions of the sympathetic and parasympathetic systems may account for the observed pattern of systemic hemodynamics, flow metabolism coupling, fast neurogenic vasodilation, and cerebral autoregulation may be involved in mediating cerebral blood flow modulations. Furthermore, during conditions of high cardiovascular reactivity, systemic hemodynamic changes exert a marked influence on cerebral blood perfusion.

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Effect of positioning from supine and left lateral positions to left lateral tilt on maternal blood flow velocities and waveforms in full-term parturients

Anaesthesia ◽

10.1111/j.1365-2044.2012.07268.x ◽

2012 ◽

Vol 67 (8) ◽

pp. 936-936 ◽

Cited By ~ 1

Author(s):

P. Kundra ◽

J. Velraj ◽

U. Amirthalingam ◽

S. Habeebullah ◽

K. Yuvaraj ◽

...

Keyword(s):

Blood Flow ◽

Maternal Blood ◽

Full Term ◽

Lateral Tilt ◽

Blood Flow Velocities ◽

Flow Velocities

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Blood rheology in acute anterior ischemic optic neuropathy

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-1991-11608 ◽

1991 ◽

Vol 11 (6) ◽

pp. 623-634 ◽

Cited By ~ 1

Author(s):

B. Bertram ◽

A. Hoberg ◽

O. Arend ◽

S. Wolf ◽

F. Jung ◽

...

Keyword(s):

Optic Neuropathy ◽

Blood Rheology ◽

Anterior Ischemic Optic Neuropathy ◽

Ischemic Optic Neuropathy

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Peripapillary vascular density in resolved non-arteritic anterior ischemic optic neuropathy: colocalization between structural and vascular parameters

Neurological Sciences ◽

10.1007/s10072-021-05378-w ◽

2021 ◽

Author(s):

Mariapaola Giordano ◽

Daniela Montorio ◽

Marina Concilio ◽

Vincenzo Brescia Morra ◽

Gilda Cennamo

Keyword(s):

Optic Neuropathy ◽

Anterior Ischemic Optic Neuropathy ◽

Vascular Density ◽

Ischemic Optic Neuropathy

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Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy

Antioxidants ◽

10.3390/antiox10060902 ◽

2021 ◽

Vol 10 (6) ◽

pp. 902

Author(s):

Jia-Ying Chien ◽

Shu-Fang Lin ◽

Yu-Yau Chou ◽

Chi-Ying F. Huang ◽

Shun-Ping Huang

Keyword(s):

Retinal Ganglion Cells ◽

Optic Neuropathy ◽

Ganglion Cells ◽

Ischemic Injury ◽

Anterior Ischemic Optic Neuropathy ◽

Heme Oxygenase 1 ◽

Related Factor ◽

Ischemic Optic Neuropathy ◽

Retinal Ganglion ◽

Oroxylin A

Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute vision loss in older people, and there is no effective therapy. The effect of the systemic or local application of steroids for NAION patients remains controversial. Oroxylin A (OA) (5,7-dihydroxy-6-methoxyflavone) is a bioactive flavonoid extracted from Scutellariae baicalensis Georgi. with various beneficial effects, including anti-inflammatory and neuroprotective effects. A previous study showed that OA promotes retinal ganglion cell (RGC) survival after optic nerve (ON) crush injury. The purpose of this research was to further explore the potential actions of OA in ischemic injury in an experimental anterior ischemic optic neuropathy (rAION) rat model induced by photothrombosis. Our results show that OA efficiently attenuated ischemic injury in rats by reducing optic disc edema, the apoptotic death of retinal ganglion cells, and the infiltration of inflammatory cells. Moreover, OA significantly ameliorated the pathologic changes of demyelination, modulated microglial polarization, and preserved visual function after rAION induction. OA activated nuclear factor E2 related factor (Nrf2) signaling and its downstream antioxidant enzymes NAD(P)H:quinone oxidoreductase (NQO-1) and heme oxygenase 1 (HO-1) in the retina. We demonstrated that OA activates Nrf2 signaling, protecting retinal ganglion cells from ischemic injury, in the rAION model and could potentially be used as a therapeutic approach in ischemic optic neuropathy.

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