scholarly journals Central Precocious Puberty as a Complication of Therapy with Adrenocorticotropin (ACTH) and an Aromatase Inhibitor for Refractory Nephrotic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Sungeeta Agrawal ◽  
Robert Gensure ◽  
Lawrence Milner ◽  
Julie Nicoletta ◽  
Abdollah Sadeghi-Nejad
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Transplant ◽  
Aromatase Inhibitor ◽  
Precocious Puberty ◽  
Idiopathic Nephrotic Syndrome ◽  
Central Precocious Puberty ◽  
Adrenal Androgens ◽  
Refractory Nephrotic Syndrome ◽  
Peripheral Precocious Puberty

Glucocorticoids are typically prescribed for the treatment of idiopathic nephrotic syndrome of childhood. In selected patients with refractory focal segmental glomuerulosclerosis (FSGS), adrenocorticotropin (ACTH) can be used to induce remission and decrease the progression of the disease. We report a 6 8/12-year-old girl with recurrent proteinuria, resistant to standard immunotherapy. She underwent related renal transplant but again developed proteinuria and was started on ACTH. She subsequently developed peripheral precocious puberty (PPP), presumably from peripheral aromatization of adrenal androgens. She was started on an aromatase inhibitor, and her ACTH dose was slowly decreased. She then developed central precocious puberty (CPP). We hypothesize that treatment of her peripheral precocious puberty with an aromatase inhibitor may have triggered central precocious puberty.

scholarly journals Precocious puberty: a clinical review

2018 ◽  
Vol 7 (3) ◽  
pp. 771
Author(s):  
Pallavee P. ◽  
Rupal Samal
Keyword(s):  
Precocious Puberty ◽  
Pubertal Development ◽  
Psychosocial Problems ◽  
Central Precocious Puberty ◽  
Biochemical Tests ◽  
Gnrh Analogues ◽  
Premature Thelarche ◽  
Epiphyseal Fusion ◽  
Peripheral Precocious Puberty

Precocious puberty is defined as pubertal development occurring more than 2.5 standard deviations earlier than the average age. It may comprise of central or gonadotropin-dependent precocious puberty and peripheral or gonadotropin-independent precocious puberty. Variants of precocious puberty include premature thelarche, premature pubarche and isolated premature menarche which principally implies onset of menstruation without any other signs of sexual development. Precocious puberty may have long-term consequences including short stature later on in adulthood owing to premature epiphyseal fusion as also psychosocial problems. Evaluation includes a detailed history, physical examination, biochemical tests and imaging directed towards detecting the cause. Gonadotropin Releasing Hormone (GnRH) analogues are effective for treatment of central precocious puberty. Treatment of peripheral precocious puberty should be based on the cause. Isolated variants are usually normal but should be closely monitored. Multi-speciality consultation with involvement of pediatricians and enocrinologists may improve treatment outcomes in these children, who otherwise pose significant challenges to the gynaecologist.

scholarly journals Central Precocious Puberty as a Complication of Congenital Adrenal Hyperplasia in a Boy: Case Report

2021 ◽  
Vol 44 (3) ◽  
pp. 184-187
Author(s):  
Farzana Sharmin ◽  
Suraiya Begum ◽  
Ismat Jahan ◽  
Tawhid Alam ◽  
Dhiraj Chandra Biswas
Keyword(s):  
Case Report ◽  
Child Health ◽  
Congenital Adrenal Hyperplasia ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Well Being ◽  
Adrenal Hyperplasia ◽  
Peripheral Precocious Puberty

Precocious puberty has intense influence on physical and psychosocial well-being of affected children and raises a lot of concerns as well as uncertainties in family.Here,we report a case of Central precocious puberty (CPP)superimposed on peripheral precocious puberty (PPP) due to congenital adrenal hyperplasia(CAH). Bangladesh J Child Health 2020; VOL 44 (3) :184-187

scholarly journals Precocious puberty: diagnosis and management

2021 ◽  
Vol 12 (1) ◽  
pp. 62-69
Author(s):  
Nusrat Sultana ◽  
Faria Afsana ◽  
Nazma Akhtar ◽  
Yasmin Aktar ◽  
Mohammad Feroz Amin ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Normal Development ◽  
Central Precocious Puberty ◽  
Gnrh Analogues ◽  
Premature Thelarche ◽  
Psychosocial Wellbeing ◽  
Epiphyseal Fusion ◽  
Final Stature ◽  
Biochemical Testing ◽  
Peripheral Precocious Puberty

Precocious puberty is commonly defined as puberty that starts before age 8 years in girls and 9 years in boys. The causes of it may range from a variant of normal development to various pathologic conditions. The etiology of precocious puberty is classified by the underlying pathogenesis into gonadotropin dependent central precocious puberty and peripheral precocious puberty which is independent of gonadotropin but due to different other causes. Variants of precocious puberty include premature thelarche, premature puberche and isolated premature menarche which imply onset of isolated changes without any other signs of sexual development. Precocious puberty might have an impact on final stature owing to premature epiphyseal fusion and also it has got influence on psychosocial wellbeing. Evaluation includes a detailed history, physical examination, biochemical testing and imaging directed towards suspected etiology. Gonadotropin releasing hormone (GnRH) analogues are effective for treatment of central precocious puberty. Treatment of peripheral precocious puberty should be based on the specific cause. Pubertal variants are usually non-progressive and need no treatment but should be monitored carefully. BIRDEM Med J 2022; 12(1): 62-69

Central precocious puberty after resection of a virilising adrenocortical oncocytic tumour

2021 ◽  
Vol 14 (5) ◽  
pp. e239562
Author(s):  
Lee Rima Madi ◽  
Naama Fisch Shvalb ◽  
Chen Sade Zaltz ◽  
Yael Levy-Shraga
Keyword(s):  
Adrenal Cortex ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Dehydroepiandrosterone Sulfate ◽  
Histological Subtype ◽  
Hormone Production ◽  
Marked Elevation ◽  
Morphological Appearance ◽  
Tumour Removal ◽  
Peripheral Precocious Puberty

Adrenocortical oncocytic tumours are a histological subtype of adrenal neoplasms with a distinctive morphological appearance. Since these tumours are composed of cells of the adrenal cortex, they may act as functional tumours with excess hormone production. They may cause Cushing’s syndrome, inappropriate virilisation or precocious puberty. Though rare during childhood, adrenocortical oncocytic tumours should be suspected in a child with peripheral precocious puberty and marked elevation of dehydroepiandrosterone sulfate levels. We describe a 6-year girl who presented with peripheral precocious puberty due to a functional adrenocortical oncocytic tumour. Three months after tumour removal, she developed true central precocious puberty. This report highlights that peripheral precocious puberty may trigger central precocious puberty, particularly after resolution of the underlying cause of the peripheral precocious puberty.

scholarly journals Distinct Gut Microbiota Structure and Function of Children With Idiopathic Central and Peripheral Precocious Puberty

2021 ◽  
Author(s):  
Congfu Huang ◽  
Haiying Liu ◽  
Wei Yang ◽  
Yinhu Li ◽  
Bin Wu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Healthy Children ◽  
Endocrine Diseases ◽  
Α Diversity ◽  
Rdna Sequencing ◽  
Different Types ◽  
Acid Producing Bacteria ◽  
Peripheral Precocious Puberty

Abstract BackgroundPrecocious puberty (PP) is one of the most common endocrine diseases in children, and the pathogenesis is currently unknown. Recent studies on the gut-brain axis have shown that there is a correlation between childhood endocrine diseases and the gut microbiota (GM). However, whether there is a correlation between children’s GM with different types of PP remains unclear.ResultsTo explore the GM characteristics of children with different types of PP, we recruited 27 idiopathic central precocious puberty children (ICPP group), 18 peripheral precocious puberty children (PPP group) and 23 healthy children of the same age (HC group). Their stool samples were subjected to 16S rDNA sequencing. In this study, we found that the OTUs numbers, the annotated genera and α-diversity of GM of ICPP and PPP group were all significantly higher than that in HC group (P < 0.05). The abundance of butyrate acid producing bacteria, such as Prevotella, Lachnospiracea incertae sedis, Roseburia, Ruminococcus and Alistipes, were significantly higher in ICPP and PPP group, while Bacteroides and Faecalibacterium were significantly higher in HC group. The GM symbiosis network showed that both Bacteroides and Faecalibacterium were negatively correlated with these butyrate-acid producing bacteria. The abundances of most significantly changed genera were gradually increased from HC to PPP, and to ICPP group, while only Bacteroides was gradually decreased. After the prediction of the metabolic pathways of the GM, cell motility, signal transduction and environmental adaptation were significantly enriched in the ICPP and PPP groups (P < 0.05), while the carbohydrate metabolism pathway were significantly decreased (P < 0.001). ConclusionsOverall, this study showed that the GM composition and functional pattern of children with ICPP and PPP are different from healthy children, and PPP may be a transitional stage between ICPP and HC children, which provide a theoretical basis for clinical intervention based on GM in the treatment of PP.

Utility of basal LH in comparison to the GnRH test for identifying central precocious puberty in girls

2014 ◽  
Author(s):  
Elizabeth Shepherd ◽  
Leena Patel ◽  
Indi Banerjee ◽  
Peter Clayton ◽  
Sarah Ehtisham ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty
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