scholarly journals Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Nicolas Gallastegui ◽  
Daniel P. Cassidy ◽  
Deborah O. Heros ◽  
Francisco Vega ◽  
Jonathan H. Schatz

Involvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia/small lymphocytic lymphoma and an embolic cerebrovascular accident related to a cardiac myxoma, who developed parenchymal central nervous system involvement of lymphoma on the ischemic bed. The patient was successfully treated with a high-dose fludarabine-based chemotherapy regimen, achieving a sustained remission. We propose that embolic breakage of the blood-brain barrier may be a major risk factor in producing central nervous system involvement. We also propose that a high-dose fludarabine-based chemotherapy regimen may be adequate to achieve a better CNS penetration and improved outcomes.

2018 ◽  
Vol 35 (2) ◽  
pp. 147-149
Author(s):  
Anna Christoforidou ◽  
Georgios Kapsas ◽  
Zoe Bezirgiannidou ◽  
Spyros Papamichos ◽  
Ioannis Kotsianidis

Haematologica ◽  
2016 ◽  
Vol 101 (4) ◽  
pp. 458-465 ◽  
Author(s):  
Paolo Strati ◽  
Joon H. Uhm ◽  
Timothy J. Kaufmann ◽  
Chadi Nabhan ◽  
Sameer A. Parikh ◽  
...  

2013 ◽  
Vol 13 (3) ◽  
pp. 338-341 ◽  
Author(s):  
Ohad Benjamini ◽  
Preetesh Jain ◽  
Ellen Schlette ◽  
Jade S. Sciffman ◽  
Zeev Estrov ◽  
...  

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