scholarly journals Assessing Biophysical and Physiological Profiles of Scalp Seborrheic Dermatitis in the Thai Population

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Poonkiat Suchonwanit ◽  
Korn Triyangkulsri ◽  
Monthanat Ploydaeng ◽  
Kanchana Leerunyakul
Keyword(s):  
Seborrheic Dermatitis ◽  
Skin Surface ◽  
Control Group ◽  
Surface Lipid ◽  
Biophysical Properties ◽  
Thai Population ◽  
Skin Surface Lipid ◽  
Physiological Profiles ◽  
The Mean ◽  
Skin Surface Ph

Background. Scalp seborrheic dermatitis (SD) is a common and chronic inflammatory skin disease which tends to recur over time. By measuring biophysical properties of the stratum corneum, many studies report abnormal biophysical profiles and their association in various dermatologic diseases. The aim of the study is to analyze the biophysical properties and skin barrier defects of scalp SD compared to healthy controls. Materials and Methods. This study is a cross-sectional study assessing the correlation of various biophysical and physiological profiles in scalp SD. Forty-two Thai participants with scalp SD were enrolled in the study and 40 healthy participants were also enrolled as the control group. Both SD and control group were subjected to a one-time biophysical and physiological properties’ measurement of transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin surface pH, skin surface lipid, and skin roughness. Results. The mean TEWL of lesional skin of SD cases were significantly higher than those of control group (P<0.05). Relating to high mean TEWL, the mean SCH was found to be significantly lower in SD cases (P<0.05). Skin surface lipid was also found to be significantly higher in SD group (P<0.05). However, there were no differences in skin surface pH (P=0.104) and roughness (P=0.308) between the two groups. Pairwise comparison of each subgroup found that moderate and severe SD demonstrated significantly higher mean skin surface lipid than that of control group (P<0.05). Conclusion. Scalp SD may be associated with seborrhea in Thai population. Monitoring of SCH, TEWL, and skin surface lipid could be helpful in assessing severity and evaluating the treatment outcome in patients with scalp SD.

scholarly journals Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manli Yang ◽  
Mingyue Zhou ◽  
Yuan Li ◽  
Hong Huang ◽  
Yan Jia
Keyword(s):  
Pregnant Women ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Surface ◽  
Individual Species ◽  
Average Chain Length ◽  
Skin Barrier Function ◽  
Control Group ◽  
Surface Lipid ◽  
Skin Surface Lipid

AbstractSelf-reported skin discomfort is a common problem during pregnancy, but it is not clear whether skin barrier function is altered in the process. Few studies have described the skin barrier function during pregnancy. In this work, we used highly sensitive and high-resolution ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to distinguish skin surface lipid (SSL) combined with multivariate analysis of lipids and metabolic changes to determine the relationship between SSL changes and skin physiology during pregnancy in order to better understand the skin condition of pregnant women. The results showed a significant reduction in the total lipid content in pregnant women. A total of 2270 lipids were detected, and the relative abundances of fatty acyls and glycerolipids were significantly reduced, while glycerophospholipids (GPs), sphingolipids, and saccharolipids was significantly increased in the pregnancy group. Multivariate data analysis indicated that 23 entities constituted the most important individual species responsible for the discrimination and phosphatidylcholine was the most abundant lipid in pregnancy group. In addition, compared to SSL profile of control group, it was observed that the average chain length of ceramides and fatty acids both decreased in SSL profile of pregnancy group. The main and most commonly affected pathway was that of GP pathways. These findings indicate that skin lipids are significantly altered in mid-pregnancy compared to the control group. Changes in ostrogen during pregnancy also make the skin more susceptible to inflammatory factors and lead to more fragile and susceptible skin, weakening the skin barrier along with the lipid alterations.

PRODUCTION OF MALONALDEHYDE FROM SQUALENE, A MAJOR SKIN SURFACE LIPID, DURING UV-IRRADIATION

1989 ◽  
Vol 49 (5) ◽  
pp. 711-716 ◽  
Author(s):  
K. JASON DENNIS ◽  
TAKAYUKI SHIBAMOTO
Keyword(s):  
Uv Irradiation ◽  
Skin Surface ◽  
Surface Lipid ◽  
Skin Surface Lipid

Analysis of human skin surface lipid during treatment with anti-androgens

1987 ◽  
Vol 117 (6) ◽  
pp. 735-740 ◽  
Author(s):  
SHUSHMA PATEL ◽  
W.C. NOBLE
Keyword(s):  
Human Skin ◽  
Skin Surface ◽  
Surface Lipid ◽  
Skin Surface Lipid

Lipidomics reveals skin surface lipid abnormity in acne in young men

2018 ◽  
Vol 179 (3) ◽  
pp. 732-740 ◽  
Author(s):  
M. Zhou ◽  
Y. Gan ◽  
C. He ◽  
Z. Chen ◽  
Y. Jia
Keyword(s):  
Young Men ◽  
Skin Surface ◽  
Surface Lipid ◽  
Skin Surface Lipid

Changes in Skin Surface Lipid During Therapy of Atopic Dermatitis

1993 ◽  
Vol 6 (4) ◽  
pp. 181-184
Author(s):  
Shushma D. Patel ◽  
W. C. Noble
Keyword(s):  
Atopic Dermatitis ◽  
Skin Surface ◽  
Surface Lipid ◽  
Skin Surface Lipid

Variation in skin surface lipid composition among the equidae

1983 ◽  
Vol 75 (3) ◽  
pp. 429-433 ◽  
Author(s):  
Sabin W. Colton ◽  
Donald T. Downing
Keyword(s):  
Lipid Composition ◽  
Skin Surface ◽  
Surface Lipid ◽  
Skin Surface Lipid

Mechanism of Skin Surface Lipid Peroxidation

2015 ◽  
pp. 135-143 ◽  
Author(s):  
Itsuro Matsuo ◽  
Kazuhiro Yoshino ◽  
Muneo Ohkido
Keyword(s):  
Lipid Peroxidation ◽  
Skin Surface ◽  
Surface Lipid ◽  
Skin Surface Lipid

Skin Surface Lipid Composition of Scalp in Adults Males

1992 ◽  
Vol 15 (1) ◽  
pp. 17
Author(s):  
Ki Bum Myung
Keyword(s):  
Lipid Composition ◽  
Skin Surface ◽  
Surface Lipid ◽  
Skin Surface Lipid

Skin penetration by cercariae of the bird schistosome Austrobilharzia terrigalensis: the stimulatory effect of cholesterol

Parasitology ◽  
1969 ◽  
Vol 59 (4) ◽  
pp. 973-989 ◽  
Author(s):  
J. A. Clegg
Keyword(s):  
Mass Spectrometry ◽  
Thin Layer ◽  
Skin Surface ◽  
Sterol Fraction ◽  
Surface Lipid ◽  
Skin Lipid ◽  
Free Sterols ◽  
Bird Schistosome ◽  
Chicken Skin ◽  
Skin Surface Lipid

An artificial skin of hardened gelatine was used to examine the factors affecting penetration of skin by cercariae of the bird schistosome, Austrobilharzia terrigalensis.The percentage of cercariae able to penetrate through a gelatine membrane was increased by a factor of 3–4 by coating the membrane with a thin layer of lipid collected from the surface of chicken skin.The free sterol fraction, isolated from chicken skin surface lipid by thin-layer chromatography, stimulated penetration to the same extent as whole skin lipid.Cholesterol was detected in the sterol fraction by mass spectrometry and pure cholesterol had the full stimulating effect on cercarial penetration.Skin lipid, from which free sterols had been removed, lost the stimulatory effect on cercariae, but full activity was recovered by adding cholesterol to the sterol-free lipid. Fractions of skin lipid containing free fatty acids or triglycerides, wax esters and sterol esters similarly failed to stimulate penetration.These results establish that penetration of A. terrigalensis cercariae is greatly stimulated by the free sterols present in the surface lipid of chicken skin but cholesterol may not be the only active sterol. Cholestanol and the plant sterols campesterol and β-sitosterol were also detected in chicken skin surface lipid. These sterols were not tested for activity on cercariae because samples free from cholesterol could not be obtained.Some cercariae were able to penetrate plain gelatine membranes not coated with cholesterol but small amounts of free sterol were detected in the gelatine itself. This sterol could not be completely removed by prolonged solvent extraction and consequently it is not known whether any cercariae are able to penetrate in the complete absence of sterols.Temperature had a marked effect on penetration of cercariae; lowering the temperature from 40 to 25 °C reduced the number of successful penetrants by a factor of 4.I am grateful to Miss V. Bowen for excellent technical assistance and to Dr J. McLeod of the Research School of Chemistry, Australian National University, who performed and interpreted the mass spectrometry. This investigation was partly supported by a research grant from the World Health Organization.

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