scholarly journals Hepatitis B Virus X Protein-Induced RORγ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Yu Huang ◽  
Huasheng Liang ◽  
Chuanxiong He ◽  
Fang Peng

Aberrant expression of RORγ is implicated in cancer development. A previous study identified that RORγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth. However, its expression and significance in HCC remain unclear. The central finding of this work is that RORγ was overexpressed in HCC due to its dysfunction of promoter methylation, and hepatitis B virus X protein (HBx) can remarkably induce the expression of RORγ in hepatocellular carcinoma through enhancing the transcriptional function. Also, the HBx-induced RORγ could promote the migration and proliferation of hepatoma cells. Hence, these results suggest that RORγ was an important regulator in HCC, and our finding provides new insights into the significance of RORγ in HCC.

2014 ◽  
Vol 8 (6) ◽  
pp. 2715-2720 ◽  
Author(s):  
SHENG-LI YANG ◽  
CHAO YU ◽  
JIAN-XIN JIANG ◽  
LI-PING LIU ◽  
XIEFAN FANG ◽  
...  

2007 ◽  
Vol 356 (2) ◽  
pp. 341-347 ◽  
Author(s):  
Juan Gao ◽  
Caiping Chen ◽  
Liu Hong ◽  
Jun Wang ◽  
Yulei Du ◽  
...  

2017 ◽  
Vol 394 ◽  
pp. 22-32 ◽  
Author(s):  
Shuzhen Chen ◽  
Zihui Dong ◽  
Pinghua Yang ◽  
Xianming Wang ◽  
Guangzhi Jin ◽  
...  

Hepatology ◽  
2008 ◽  
Vol 49 (4) ◽  
pp. 1122-1131 ◽  
Author(s):  
Tae-Young Na ◽  
Young Kee Shin ◽  
Kyung Jin Roh ◽  
Shin-Ae Kang ◽  
Il Hong ◽  
...  

2015 ◽  
Vol 5 ◽  
pp. S1
Author(s):  
Suchandrima Ghosh ◽  
Alip Ghosh ◽  
Amit Ghosh ◽  
Somenath Datta ◽  
Debanjali Dasgupta ◽  
...  

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