Acute Laryngeal Dyspnea as the First Presentation of Mantle Cell Lymphoma: A Case Report and Review of the Literature

Introduction. Acute laryngeal dyspnea is a life-threatening emergency, and the causes in adults are most often laryngeal tumors or inflammatory edema. Lymphoma of the larynx and especially the mantle cell type is extremely rare. Case Presentation. We report a case of a 43-year-old woman with no particular pathological history. She presented with progressive dyspnea which has evolved towards an inspiratory bradypnea that worsened until she ultimately required an emergency tracheotomy. Biopsies revealed mantle cell lymphoma. The patient has been staged IVB MIPI 6, and she was treated by immunochemotherapy followed by ASCT. The therapeutic evaluation shows a complete remission, 18 months after, and the patient was always disease free. Conclusion. The laryngeal localization of the mantle cell lymphoma is extremely rare; it may present catastrophically with acute airway obstruction. The diagnosis is mostly histological, hence the interest of deep biopsy. Given its rarity, the therapeutic strategy must be discussed case by case in a multidisciplinary consultation meeting.

Download Full-text

Spontaneous Splenic Rupture and Rituximab-Induced Acute Thrombocytopenia in a Patient with High-Risk Mantle Cell Lymphoma

Case Reports in Hematology ◽

10.1155/2019/2429098 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Jared Williams ◽

Shingi Chiruka

Keyword(s):

High Risk ◽

Mantle Cell Lymphoma ◽

Rare Case ◽

Splenic Rupture ◽

Cell Lymphoma ◽

Case Reports ◽

Spontaneous Splenic Rupture ◽

Rare Type ◽

Mantle Cell ◽

Life Threatening

Mantle cell lymphoma is a relatively rare type of mature B-cell non-Hodgkin’s lymphoma with an incidence of approximately 8 cases per million persons per year. In patients with mantle cell lymphoma, there are rare case reports of the potentially life-threatening consequences of splenic rupture and rituximab-induced acute thrombocytopenia (RIAT) occurring separately, but there are no reports of these occurring in the same patient. Whilst rare, they are important to be aware of as early detection may prevent fatal outcomes.

Download Full-text

Mantle Cell Lymphoma Case Report

Case Reports in Oncology ◽

10.1159/000492665 ◽

2018 ◽

Vol 11 (3) ◽

pp. 814-821

Author(s):

V.I. Podzolkov ◽

T.S. Vargina ◽

A.E. Pokrovskaya ◽

T.A. Safronova ◽

A.A. Abramova

Keyword(s):

Mantle Cell Lymphoma ◽

Cell Lymphoma ◽

Final Diagnosis ◽

Lymphoproliferative Diseases ◽

Case Presentation ◽

Mantle Cell ◽

Cytogenetic Analyses ◽

Lymphoproliferative Syndrome ◽

Definition Of ◽

The Right

Introduction: Due to the beginning of the use of immunophenotypic and cytogenetic techniques, new nosological forms of lymphoproliferative diseases have appeared over the past few decades. According to the WHO classification (2008), today there are more than 50 known lymphoproliferative diseases. Case Presentation: We present the case of a 51-year-old man with lymphoproliferative syndrome. Our patient underwent morphological and immunohistochemical investigations of biopsy materials from the right inguinal lymph node. The morphological picture was characteristic for small cell lymphoma. Immunophenotypically, tumor proliferate cells expressed CD20, CD76b, CD5, and cyclin D, and the tumor immunophenotype matched mantle cell lymphoma. Discussion: At the present stage of the development of medicine, the diagnosis of lymphoproliferative diseases is based on the clinical picture of the disease with the definition of localization and characteristics of the tumor process, morphological study of tumor tissue and cells, and immunophenotypic and/or cytogenetic analyses are mandatory to determine the final diagnosis.

Download Full-text

Mantle Cell Lymphoma Presenting with Severe Upper GI Bleeding.

10.21203/rs.3.rs-439768/v1 ◽

2021 ◽

Author(s):

Khaled Ali ◽

Mhd Baraa Habib ◽

Ferial Alloush ◽

Mohamed A. Yassin

Keyword(s):

Peptic Ulcer ◽

Gastric Ulcer ◽

Mantle Cell Lymphoma ◽

Cell Lymphoma ◽

Gi Bleeding ◽

Ulcer Disease ◽

Upper Gi Bleeding ◽

Upper Gi ◽

Mantle Cell ◽

Life Threatening

Abstract Although it usually involves extra-nodal sites such as gastrointestinal tract in more than 80% of case, Mantle cell lymphoma is considered a rare cause of gastrointestinal bleeding, especially a severe and life-threatening bleeding. We are reporting a 60 year old man, known to have peptic ulcer disease, who presented with a severe upper GI bleeding and found to have large gastric ulcer, which diagnosed as primary gastric mantle cell lymphoma.

Download Full-text

Primary Testicular Mantle Cell Lymphoma in a 23-Year-Old Man: A Case Report and Review of the Literature

10.21203/rs.3.rs-620293/v1 ◽

2021 ◽

Author(s):

Yanan Gao ◽

Runfen Cheng ◽

Yi Pan ◽

Qiongli Zhai

Keyword(s):

Mantle Cell Lymphoma ◽

Cell Lymphoma ◽

Surgical Excision ◽

Pathological Examination ◽

Review Of The Literature ◽

Elderly Men ◽

Aberrant Expression ◽

Case Presentation ◽

First Case ◽

Mantle Cell

Abstract Background: Primary testicular mantle cell lymphoma (PTMCL) is a very rare disease, mostly occurred in elderly men, usually diagnosed at an advanced stage. Mantle cell lymphoma (MCL) has a distinctive immunophenotype, positive for CD5 and cyclin D1, but negative for CD10 and CD23. The genetic hallmark of MCL is t(11;14)(q13;q32). Case presentation: Here we reported a case of 23-year-old man who presented with a tumor in the testis. Surgical excision and pathological examination revealed the lesion was a primary testicular mantle cell lymphoma with aberrant expression of CD10 and loss of CD5. Conclusion: This study reports the first case of PTMCL in a 23-year-old man with aberrant expression of CD10 and loss of CD5, summarizes PTMCL reported in PUBMED and found that CD5 might be an independent factor that influences not only the diagnosis but also the prognosis of MCL.

Download Full-text

Ibrutinib Is Effective in the Treatment of Autoimmune Haemolytic Anaemia in Mantle Cell Lymphoma

Case Reports in Oncology ◽

10.1159/000456002 ◽

2017 ◽

Vol 10 (1) ◽

pp. 127-129 ◽

Cited By ~ 4

Author(s):

Aliénor Galinier ◽

Vincent Delwail ◽

Mathieu Puyade

Keyword(s):

Mantle Cell Lymphoma ◽

Haemolytic Anaemia ◽

Steroid Therapy ◽

Cell Lymphoma ◽

Autoimmune Haemolytic Anaemia ◽

Mantle Cell ◽

Life Threatening ◽

Immunomodulatory Drug ◽

Life Threatening Complication

Autoimmune haemolytic anaemia (AIHA) in mantle cell lymphoma (MCL) is a rare but life-threatening complication. To date, there are no relevant data for treatment of AIHA in MCL. Ibrutinib, which has been approved for relapse/refractory MCL, is an immunomodulatory drug inhibiting Th2 activation and consequently the production of autoantibodies. We report a case of MCL with AIHA in which this form of anaemia was not controlled with the usual chemotherapy. Ibrutinib was used when MCL with AIHA relapsed, and it allowed rapid remission of AIHA and rapid discontinuation of steroid therapy.

Download Full-text