scholarly journals INI1-Intact Sinonasal Carcinoma with Rhabdoid Features

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Erin Mulry ◽  
Danielle M. Blake ◽  
Poornima Hegde ◽  
Todd E. Falcone
Keyword(s):  
Maxillary Sinus ◽  
Poor Prognosis ◽  
Advanced Disease ◽  
Surgical Excision ◽  
Large Mass ◽  
Sinonasal Malignancies ◽  
Poorly Differentiated ◽  
Complex Features ◽  
Maxillary Sinus Pathology ◽  
Rhabdoid Features

Sinonasal malignancies are known for their associated poor prognosis and diversity of histologic features. While poor prognosis is largely due to advanced disease at presentation, histologic features also play a significant role. Therefore, accurate pathologic diagnosis is of utmost importance. Here, we describe a 63-year-old male with chronic left-sided nasal obstruction and left-sided epistaxis who was found to have a large mass occupying most of the nasal cavity extending through the nasopharynx to just below the nasopharyngeal surface of the soft palate. During surgical excision, the mass was noted to originate from the floor of the maxillary sinus with erosion of the medial wall of the maxillary sinus. Pathology revealed a diagnosis of INI1-intact poorly differentiated composite carcinoma with rhabdoid phenotype and sarcomatoid and squamous cell carcinoma foci arising within an inverted papilloma. Included in this report is a detailed description of both the patient’s medical course and this pathologically novel sinonasal neoplasm. We aim to elucidate this rare tumor’s complex features in order to improve future diagnosis and stimulate prospective research on sinonasal malignancies with complex histology.

scholarly journals Intrascrotal lipoblastoma in adulthood

2019 ◽  
Vol 12 (12) ◽  
pp. e231320
Author(s):  
Mário José Pereira-Lourenço ◽  
Duarte Vieira-Brito ◽  
João Pedro Peralta ◽  
Noémia Castelo-Branco
Keyword(s):  
Case Report ◽  
Magnetic Resonance ◽  
S100 Protein ◽  
Surgical Excision ◽  
Large Mass ◽  
Histological Diagnosis ◽  
Physical Exam ◽  
Nodular Lesion ◽  
Inferior Portion ◽  
The Right

This case report describes the case of a 37-year-old man that noticed an intrascrotal right mass with 1 month of evolution. During physical exam presented with a large mass at the inferior portion of the right testicle, clearly separated from the testicle, with a tender consistency and mobile. An ultrasound was performed that showed a solid and subcutaneous nodular lesion, extra testicular, heterogeneous, measuring 7.2 cm. Pelvic magnetic resonance imageMRI showed a lesion compatible with a lipoma. The patient was subjected to surgical excision of the lesion by scrotal access, having histology revealed a lipoblastoma (LB) of the scrotum. Histological diagnosis was obtained by microscopic characteristics (well-circumscribed fatty neoplasm) and immunohistochemistry (stains for CD34, S100 protein and PLAG1 were positive; stains for MDM2 and CDK4 were negative). LB is extremely rare after adolescence in any location, being this first described case of intrascrotal LB described in adulthood.

scholarly journals Gastric cancer with repeated metastasis in the colonic lumen: a case report and multi-surgical experience

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110184
Author(s):  
Yi Wang ◽  
Peiqing Ma ◽  
Kan Liu ◽  
Dongkui Xu ◽  
Qian Liu
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Poor Prognosis ◽  
Partial Gastrectomy ◽  
Radical Resection ◽  
Surgical Experience ◽  
Colonic Lumen ◽  
Poorly Differentiated ◽  
Gastric Stump Carcinoma ◽  
Peritoneal Spread

Poorly differentiated gastric adenocarcinoma is commonly associated with lymph node metastasis, peritoneal spread, and liver metastasis but rarely with intraintestinal metastasis. Most patients with metastatic gastric carcinoma are unable to undergo surgical treatment and have a poor prognosis. A 42-year-old man with hunger-related abdominal pain was diagnosed as having gastric cancer. After the first surgery (distal partial gastrectomy) and the second surgery (gastric stump carcinoma (GSC) resection), the patient suffered repeated multiple intracolonic metastases and underwent three additional resection operations. The patient survived for 154 months after the first operation. In patients with gastric carcinoma that metastasizes to the colonic lumen, radical resection, if possible, can extend survival. Once patients develop extensive extraintestinal metastasis, radical resection cannot be performed, and patients often exhibit a poor prognosis.

scholarly journals Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis

2020 ◽  
Vol 9 (3) ◽  
pp. 603-616 ◽  
Author(s):  
Tobias Raphael Overbeck ◽  
Dana Alina Cron ◽  
Katja Schmitz ◽  
Achim Rittmeyer ◽  
Wolfgang Körber ◽  
...  
Keyword(s):  
Copy Number ◽  
Poor Prognosis ◽  
Gene Copy Number ◽  
Copy Number Gain ◽  
Gene Copy ◽  
Poorly Differentiated ◽  
Gene Copy Number Gain

Small Cell Carcinocythemia

1999 ◽  
Vol 123 (5) ◽  
pp. 426-428
Author(s):  
Cynthia C. Sile ◽  
David J. Perry ◽  
Lucy Nam
Keyword(s):  
Lung Cancer ◽  
Poor Prognosis ◽  
Advanced Disease ◽  
Small Cell ◽  
Small Cell Lung ◽  
Peripheral Smear ◽  
Stage Disease ◽  
Splenic Metastases ◽  
Generalized Lymphadenopathy ◽  
End Stage

Abstract Tumor cells circulate in the blood, but it is unusual to find cancer cells on a routine peripheral smear. The term carcinocythemia is used to describe this phenomenon. Four patients have been reported previously with small cell lung cancer and carcinocythemia. A fifth case is described in this article. These patients presented with advanced disease and had generalized lymphadenopathy and liver involvement; 3 had splenic metastases. All of these patients experienced rapid clinical deterioration. Death occurred 3 days to 2 weeks from the time carcinocythemia was detected. The presence of small cell carcinocythemia can be one of the manifestations of end-stage disease and is associated with an extremely poor prognosis.

scholarly journals Nine Cases of Merkel Cell Tumour

1997 ◽  
Vol 90 (8) ◽  
pp. 439-442 ◽  
Author(s):  
Aniruddha Bose
Keyword(s):  
Metastatic Disease ◽  
Advanced Disease ◽  
Surgical Excision ◽  
Primary Treatment ◽  
Cell Tumour ◽  
Neuroendocrine Neoplasm ◽  
Merkel Cell ◽  
Histochemical Examination

Merkel cell tumour is an aggressive neuroendocrine neoplasm arising in the dermis. Although only a few hundred cases have been reported worldwide, nine were seen in Nottingham between 1985 and early 1994. The patients were five women and four men age 63–88. One was the first Afro-Caribbean reported to have such a tumour. In no case was the diagnosis made clinically; histological and histochemical examination was necessary. Three of the patients died quickly with metastatic disease. The primary treatment is surgical excision. For advanced disease, radiotherapy is commonly beneficial

scholarly journals More than meets the eye

2019 ◽  
Vol 12 (2) ◽  
pp. bcr-2015-212000 ◽  
Author(s):  
Ailbhe White-Gibson ◽  
Paul Lennon ◽  
Esther O’Regan ◽  
Conrad Timon
Keyword(s):  
Maxillary Sinus ◽  
Nasal Congestion ◽  
Surgical Excision ◽  
Cell Adenoma ◽  
Rare Tumour ◽  
Duct Carcinoma ◽  
Oncological Treatment ◽  
Hybrid Tumour ◽  
Epithelial Myoepithelial Carcinoma ◽  
High Index Of Suspicion

We report an extremely rare case of a hybrid tumour of the maxillary sinus. A 51-year-old man presented with a 6-week history of nasal congestion and epiphora. Radiological imaging demonstrated a maxillary sinus tumour, with extensive local invasion. Surgical excision included maxillectomy, left eye exenteration and free flap closure. Histology of the excised specimen showed a rare hybrid tumour containing adenoid cystic carcinoma, salivary duct carcinoma, epithelial-myoepithelial carcinoma and basal cell adenoma. Hybrid tumours are very rare tumour entities which are composed of at least two distinct tumour types. Each tumour entity conforms with a defined tumour type. The tumour entities of a hybrid tumour are not separated but have an identical origin within a definite topographical area. Diagnosis and appropriate management requires high index of suspicion, pathological endeavour to look for a more aggressive accompanying tumour and adequate oncological treatment according to the highest grade of tumour.

Endoscopic ultrasound-guided coeliac plexus block

2018 ◽  
Author(s):  
Arun Bhaskar
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
Drug Delivery Systems ◽  
Advanced Disease ◽  
Celiac Plexus ◽  
Needle Placement ◽  
Ultrasound Guided ◽  
Tumour Infiltration ◽  
Plexus Block ◽  
Guide Needle

The landmark paper discussed in this chapter is ‘Endosonography-guided celiac plexus neurolysis’, published by Wiersema and Wiersema in 1996. Pain is one of its most distressing complaints of pancreatic cancer, affecting more than 80% of patients with advanced disease. However, the use of opioids and other drugs is often limited by undesirable side effects, which include somnolence, confusion, lethargy, and decreased cognitive function. Intrathecal drug delivery systems, although effective, are often deemed impractical in pancreatic cancer, due to its poor prognosis and the fact that it is often diagnosed late. Tumour infiltration of the coeliac plexus results in pain in the abdomen and back; thus, this area has often been targeted for analgesia via a neurolytic coeliac plexus block. The paper by Wiersema and Wiersema examines the efficacy of an approach that uses ultrasound to guide needle placement in celiac plexus neurolysis, in a study of 30 patients.

Sign in / Sign up

Export Citation Format

Share Document