scholarly journals Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Somaya Safi ◽  
Yousra Benabdelfedil ◽  
Sara Derrou ◽  
Faycal El Guendouz
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Complete Response ◽  
Thyroid Stimulating Hormone ◽  
Suppressive Therapy ◽  
Papillary Thyroid ◽  
Case Presentation ◽  
Moroccan Woman ◽  
Potential Link ◽  
Concurrent Case

Background. The thyrotropin-secreting adenomas are very rare and even more rare when they simultaneously coexist with thyroid carcinoma. So far, only sixteen cases have been reported in the literature. Here, we present a unique case of successful management of a concurrent case of thyrotropin-prolactinoma with papillary thyroid carcinoma. Case Presentation. A 50-year-old Moroccan woman underwent a total thyroidectomy and complementary totalization by iratherapy for papillary thyroid carcinoma, who presented persistence of an inappropriate secretion of the thyroid-stimulating hormone (TSH > 4 mUI/L) despite of levothyroxine suppressive therapy (300 μg/d). After eliminating noncompliance, interfering medicines, and thyroid malabsorption, a pituitary adenoma (12 mm) was documented at magnetic resonance imaging. The patient has had transsphenoidal pituitary adenomectomy with histology confirming a thyrotropin-prolactin-secreting adenoma. After surgery and lanreotide treatment failures, we noted a complete response (TSH < 0.5) with cabergoline treatment (3 mg/week). Conclusion. The unusual association of thyroid adenocarcinoma and TSHoma enriches the hypothesis of a potential link between thyrotropic hypersecretion and thyroid carcinogenesis. Our case also illustrates the difficulty of monitoring thyroid carcinoma in nonremission of a TSHoma.

scholarly journals Treatment with Intramuscular Levothyroxine in Refractory Hypothyroidism

2019 ◽  
Vol 8 (6) ◽  
pp. 319-323 ◽  
Author(s):  
María de los Ángeles Garayalde Gamboa ◽  
Melina Saban ◽  
Marina Ines Curriá
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Hormone Level ◽  
Partial Gastrectomy ◽  
Thyroid Stimulating Hormone ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Case Presentation ◽  
Iodine 131 ◽  
Multiple Episodes

Introduction: Orally and daily levothyroxine (LT4) is the treatment of choice for hypothyroidism. In the majority of cases, the lack of effectiveness by this way may be due to poor adherence; however, gastrointestinal malabsorption may explain more cases of thyroxine refractoriness than previously reputed, due to the number of occult forms of these disorders. Case Presentation: A 55-year-old white man with a diagnosis of low risk of recurrence of follicular variant of papillary thyroid carcinoma was treated with total thyroidectomy, 30 mCi iodine 131, and oral LT4. A year before he presented a gastric adenocarcinoma that required a partial gastrectomy. He evolved with multiple episodes of intestinal subocclusion that had to be treated with enterectomy in the first instance, then digestive rest and total parenteral nutrition. In spite of having made increases in oral LT4 dose (3 µg/kg), the patient persisted with a thyroid-stimulating hormone level >100 mIU/L. For this reason, we decided to administer intramuscular LT4. Conclusion: Since there are no guidelines or consensus of intramuscular LT4 use, our experience and how we decided the dose and way of administration are presented in this article to contribute to future cases.

scholarly journals Occurrence of paratesticular ganglioneuroma 18 years after concurrent adrenal ganglioneuroma and papillary thyroid carcinoma – a case report

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chu-Wen Fang ◽  
Jyh-Seng Wang ◽  
Tony T. Wu ◽  
Jen-Tai Lin
Keyword(s):  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Ganglion Cells ◽  
Posterior Mediastinum ◽  
Papillary Thyroid ◽  
Case Presentation ◽  
Fibrous Stroma ◽  
Thyroid Papillary ◽  
Children And Young Adults

Abstract Background Ganglioneuromas (GNs) are composed of mature ganglion cells and Schwann cells with a fibrous stroma; GNs are most often observed in children and young adults. The majority of non-cranial GNs are located in the retroperitoneum and posterior mediastinum. Other reported rare sites include the adrenal gland, small intestine, colon and urinary bladder. However, para-testicular GNs are even more rare. Case presentation Herein, we report the case of a patient with concurrent adrenal GN and thyroid papillary carcinoma who developed paratesticular GN eighteen years later. Conclusions We conclude that there is an association among papillary thyroid carcinoma, GN and MEN2 syndromes. This case report may provide important information for the proposed association. However, further studies are required.

Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature

2018 ◽  
Vol 31 (4) ◽  
pp. 461-467 ◽  
Author(s):  
Ryota Otsubo ◽  
Zhanna Mussazhanova ◽  
Yuko Akazawa ◽  
Ayako Sato ◽  
Katsuya Matsuda ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Nuclear Power ◽  
Radioactive Iodine ◽  
Cervical Lymph Node Metastasis ◽  
Papillary Thyroid ◽  
Review Of Literature ◽  
Case Presentation ◽  
Western Population ◽  
Old Japanese

AbstractBackground:There have been great concerns about pediatric thyroid cancers after the accident at the Fukushima Daiichi Nuclear Power Plant in 2011.Case presentation:We report a case of a 7-year-old Japanese girl with sporadic papillary thyroid carcinoma (PTC) harboring anETV6/NTRK3rearrangement. The patient presented with tumors in both lobes and underwent thyroidectomy followed by radioactive iodine (RAI) ablation. Histopathology showed a classic type of PTC with cervical lymph node metastasis.Conclusions:Genetic evaluation showedETV6/NTRK3fusion but noBRAFmutations orRET/PTCrearrangements.RET/PTCrearrangement andBRAFmutations often contribute to the pathogenesis of PTC; however, rearrangements ofNTRKgenes are relatively rare in pediatric PTC. AlthoughNTRKrearrangement has been shown to often present unique pathological types and infiltrative architectures in the western population, such findings were not observed in this patient. Thus, the present case of classic PTC withETV6/NTRK3rearrangement highlights the disparate collection of clinic-pathological features compared to the trend in the western population. We therefore emphasize the need to further accumulate clinical as well as genetic data in pediatric PTCs.

scholarly journals Diffuse sclerosing variant of papillary thyroid carcinoma: a case report

2020 ◽  
Author(s):  
Siyao Wang ◽  
Rui Wang ◽  
Ruize Sun ◽  
Xiaoman Luo ◽  
Yue Xuan ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Case Presentation ◽  
Diffuse Sclerosing Variant ◽  
Color Duplex Ultrasonography ◽  
Right Lobe ◽  
Final Histological Diagnosis ◽  
The Right ◽  
Medical University

Abstract Background: The diffuse sclerosing variant of papillary thyroid carcinoma (DSVPC) is a rare variant of papillary thyroid carcinoma with features of strong ability of invasion, metastasis, relapse, and mortality. Its diagnosis is difficult to obtain because of the special differentiation state of the cancer cells. Case Presentation: A 21-year-old woman arrived at the First Affiliated Hospital of China Medical University in October 2019 because of a peach-pit-sized mass that she had noticed 1 month before. Color duplex ultrasonography findings suggested a thyroid nodule. Conclusions: Based on findings of the specialist examination, physical examination, and thyroid ultrasonography, the patient was initially diagnosed with thyroid neoplasm. Under general anesthesia, thyroidectomy was performed, removing the right lobe and isthmus, and biopsy specimens were obtained from lymph node groups III, IV, and VI on the right side. The final histological diagnosis was DSVPC.

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