Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma

Background. The thyrotropin-secreting adenomas are very rare and even more rare when they simultaneously coexist with thyroid carcinoma. So far, only sixteen cases have been reported in the literature. Here, we present a unique case of successful management of a concurrent case of thyrotropin-prolactinoma with papillary thyroid carcinoma. Case Presentation. A 50-year-old Moroccan woman underwent a total thyroidectomy and complementary totalization by iratherapy for papillary thyroid carcinoma, who presented persistence of an inappropriate secretion of the thyroid-stimulating hormone (TSH > 4 mUI/L) despite of levothyroxine suppressive therapy (300 μg/d). After eliminating noncompliance, interfering medicines, and thyroid malabsorption, a pituitary adenoma (12 mm) was documented at magnetic resonance imaging. The patient has had transsphenoidal pituitary adenomectomy with histology confirming a thyrotropin-prolactin-secreting adenoma. After surgery and lanreotide treatment failures, we noted a complete response (TSH < 0.5) with cabergoline treatment (3 mg/week). Conclusion. The unusual association of thyroid adenocarcinoma and TSHoma enriches the hypothesis of a potential link between thyrotropic hypersecretion and thyroid carcinogenesis. Our case also illustrates the difficulty of monitoring thyroid carcinoma in nonremission of a TSHoma.

Identification of p.Met215Ile mutation of the MC4R gene in a Moroccan woman with obesity

The MC4R is involved in the leptin-melanocortin pathway which mutations can lead to severe forms of obesity. We report one rare mutation p.Met215Ile in a woman with morbid obesity. This mutation leads to changes in protein structure through the loss of hydrophobic interactions and it is predicted to be disease-causing.

HEMICHOREA-HEMIBALLISMUS INDUCED BY NON-KETOTIC HYPERGLYCEMIA: CASE REPORT

Non-ketotic hyperglycemia with hemichorea-Hemiballismus (HGSC) is a rare complication of a non-equilibrated diabetic disease characterized by a continuous rapid, non-rhythmic, involuntary unilateral movement of the extremities, caused in most cases by decreased activity of the contralateral subthalamic nucleus of the basal ganglia. It may reveal undiagnosed diabetes. We describe here the case of an 84-year-old Moroccan woman followed for type 2 diabetes mellitus under treatment, who presented with abnormal movements of the right half-body. Laboratory tests showed higher blood glucose levels, urinary ketones were negative, brain CT without injection showed high density in the basal ganglia on the left side.

Morocco from a Colonial to a Postcolonial Era

Women of color have long used the transformative power of writing and theorizing through their bodies to speak back to the pervasive racist and sexist hierarchies in hegemonic cultures. I extend this argument in the specific context of Muslim feminism that is theorized outside orientalist and patriarchal frames of reference. In this article, I turn to a performative autoethnographic approach to look at the Moroccan era, ‘Now and Then,’ through my grandmother’s lens, that of a Moroccan woman erased from the written history of Morocco. Drawing on ‘theories of the flesh,’ I privilege my grandmother’s voice and her embodied experience that transmits her story of resistance and survival under French colonization. Through ‘fleshing,’ my Moroccan grandmother reclaims her lived experiences and deconstructs the hegemonic universalist knowledge of feminism and struggle. It is important to foreground the political urgency of surveying the theoretical frameworks of Arab and Muslim scholars in order to create new ways of understanding communication in postcolonial/neocolonial settings.

Large Choroidal Melanocytoma Simulating Choroidal Melanoma: A Difficult Differential Diagnosis and an Inevitable Enucleation

Purpose. To describe a case of choroidal melanocytoma mimicking a melanoma. Methods. Retrospective case report. Patient. A 48-year-old Moroccan woman presented with progressive, painless decreased vision in her left eye for 2 months. Results. Her visual acuity was light perception in the left eye and 20/20 in the right one. Fundus examination and fluorescein angiography of the left eye showed a total retinal detachment with a large superior brownish mass. The clinical examination, B-scan ultrasonography, and magnetic resonance imaging all suggested a malignant melanoma. Consequently, the eye was enucleated. The histopathology later revealed a benign melanocytoma of the choroid. Discussion. Melanocytoma is a rare benign pigmented tumor. It is classically described as a tumor of the optic nerve head, but there are some exceptional case reports of uveal tract locations (iris, ciliary body, and choroid). In such cases, it can be difficult to clinically differentiate a melanocytoma from a malignant melanoma.

The Preservation and Continuation of Sephardi Art in Morocco

While it is widely known that the Jews of medieval Spain carried with them their language, literature and other traditions to the countries in which they settled following the Expulsion in 1492, little research has been conducted on the preservation of their material culture and the visual arts. In this article, these aspects are examined vis-à-vis the Judaic artistic production and visual realm of the Sephardi Jews in Morocco, who adhered to these traditions perhaps more staunchly than any other Sephardi community in modern times. The materials are divided into several categories which serve as an introduction to specific topics that each require further research. These include Hebrew book printing, Jewish marriage contracts (ketubbot), Hebrew manuscript decoration, clothing and jewellery relating to the world of the Sephardi-Moroccan woman and the interior of the home, and ceremonial objects for the synagogue.

Amlodipine Induced Gingival Overgrowth, Unusual Defect and The Impact of Oral Environment: A Case Report

Introduction: Calcium-channel blockers are known for their buccal side effect as Gingival Overgrowth (GO). Although Amlodipine is considered a safe drug, it may induce gingival overgrowth for some individuals, inducing then, an aesthetic prejudice for the patient and causing serious managerial problems for clinicians. This case reports unusual defects of Amlodipine-induced gingival overgrowth, with a large gingival mass that almost completely disappeared only after improving the buccal environment. Case Study: A 51-year old Moroccan woman was complaining of gingival bleeding swelling. The examination revealed a general GO on the labial side, from the 22 to 15. It involved the entire height of the keratinized gingiva, including papillae on the buccal side. The oral hygiene was really defective with abundant plaque and calculus. The patient had hypertension and daily treated by Amlodipine 5mg for one year. But she developed the GO just few months before her first visit. The mass, associated with a chronic periodontitis, almost disappeared after scaling and root planning. Such a minimal surgical treatment showed improvement with no drug substitution or reduction. She was regularly followed up for 10 months. Conclusion: Improvement of oral hygiene, associated to periodontal non-surgical treatment alone, can afford clinical satisfaction. Changing the patient’s medication should be the last solution when local measures fail.

Case of Erdheim–Chester presenting with xanthelasma-like eruption and osteolytic bone lesions: A case report

Erdheim–Chester disease is a rare multisystemic non-Langerhans cell histiocytosis presenting 95% with skeletal lesions. Erdheim–Chester disease is due to mutations in the RAS-MEK-ERK pathway where 50% are due to BRAF-V600E mutations. Typical histopathological, clinical, and radiologic features are necessary for the diagnosis of Erdheim–Chester disease. Prognosis depends on the extent of the systemic involvement, and central nervous system involvement has a poorer outcome. We present a 30-year-old Moroccan woman with diabetes insipidus, bone marrow, and asymmetrical axial osteolytic bone lesions. Biopsies were consistent with Erdheim–Chester disease. Despite no treatment, the patient has demonstrated clinical improvement.