Diagnostic Accuracy of Combined PET/CT with MRI, 18F-FDG PET/MRI, and 18F-FDG PET/CT in Patients with Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Introduction. The aim of this paper is to compare the diagnostic accuracy of PET/CT, PET/MRI, and the combination of PET/CT and MRI for detecting synchronous cancer and distant metastasis in patients with oropharyngeal and hypopharyngeal squamous cell carcinomas (OHSCC). Method. A large and growing body of literature has been conducted using the Preferred Reporting Items for Systematic Reviews (PRISMA). The researchers collected all accessible literature existing through Cochrane Library (John Wiley & Sons) electronic databases, Embase (Elsevier), PubMed (U.S. National Library of Medicine), Scopus, and Google Scholar up to June 2020. Analyses were conducted using Stata version 12.0 (StataCorp LP). Results. A total of nine studies consisting of 1166 patients were included. The pooled sensitivity of combined PET/CT with MRI, 18F-FDG PET/MRI, and 18F-FDG PET/CT was 0.92, 0.80, and 0.79, respectively, and the corresponding specificities were 0.93, 0.91, and 0.88. The overall prevalence of distant metastases and synchronous cancer in patients with oropharyngeal and hypopharyngeal squamous cell carcinomas was 9.2% and 11.8%, respectively, with the esophagus (4.6%) being the most common site of synchronous cancer. The most common sites of distant metastases were lung (3%), bone (1.2%), and distant lymph nodes (1.2%), respectively. Conclusion. Our study showed an approximately similar diagnostic performance for PET/CT, PET/MRI, and the combination of PET/CT and MRI for metastasis assessment in advanced oropharyngeal and hypopharyngeal squamous cell carcinomas.

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FDG-PET/CT identified distant metastases and synchronous cancer in squamous cell carcinoma of the head and neck: the impact of smoking and P16-s

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-021-06890-7 ◽

2021 ◽

Author(s):

Mogens Bernsdorf ◽

Annika Loft ◽

Anne Kiil Berthelsen ◽

Julie Kjems ◽

Ivan Richter Vogelius ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Fdg Pet ◽

Distant Metastases ◽

Synchronous Cancer ◽

Pet Ct ◽

Fdg Pet Ct ◽

The Impact

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Is 18F-FDG PET/CT Useful for Selecting Right Candidates for Endoscopic Resection Among Patients With Superficial Esophageal Squamous Cell Carcinomas?

The American Journal of Gastroenterology ◽

10.14309/00000434-201410002-00061 ◽

2014 ◽

Vol 109 ◽

pp. S22

Author(s):

Yaqi Zhai ◽

Enqiang Linghu ◽

Huikai Li ◽

Baixuan Xu ◽

Liping Fu ◽

...

Keyword(s):

Endoscopic Resection ◽

Squamous Cell ◽

Fdg Pet ◽

Squamous Cell Carcinomas ◽

Pet Ct ◽

Esophageal Squamous Cell Carcinomas ◽

18F Fdg ◽

Fdg Pet Ct

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18F-FDG PET/CT and MRI in the follow-up of head and neck squamous cell carcinoma

Contrast Media & Molecular Imaging ◽

10.1002/cmmi.425 ◽

2011 ◽

Vol 6 (4) ◽

pp. 260-266 ◽

Cited By ~ 11

Author(s):

Rose Ghanooni ◽

Isabelle Delpierre ◽

Michèle Magremanne ◽

Catherine Vervaet ◽

Nicolas Dumarey ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Fdg Pet ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Ct And Mri

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CT, MR, 18F-FDG PET/CT, and their combined use for the assessment of mandibular invasion by squamous cell carcinomas of the oral cavity

Acta Radiologica ◽

10.3109/02841851.2010.520027 ◽

2010 ◽

Vol 51 (10) ◽

pp. 1111-1119 ◽

Cited By ~ 44

Author(s):

Dong Hyeon Gu ◽

Dae Young Yoon ◽

Chan Hee Park ◽

Suk Ki Chang ◽

Kyoung Ja Lim ◽

...

Keyword(s):

Oral Cavity ◽

Squamous Cell ◽

Fdg Pet ◽

Squamous Cell Carcinomas ◽

Combined Use ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Diagnostic Accuracy of 18F-FDG-PET/CT and MRI in Predicting the Tumor Response in Locally Advanced Cervical Carcinoma Treated by Chemoradiotherapy: A Meta-Analysis

Contrast Media & Molecular Imaging ◽

10.1155/2021/8874990 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Sharareh Sanei Sistani ◽

Fateme Parooie ◽

Morteza Salarzaei

Keyword(s):

Diagnostic Accuracy ◽

Fdg Pet ◽

Meta Analysis ◽

Locally Advanced ◽

Advanced Cervical Carcinoma ◽

Pet Ct ◽

18F Fdg ◽

Diagnostic Sensitivity And Specificity ◽

Fdg Pet Ct ◽

Ct And Mri

Objective. The aim of this meta-analysis was to compare the diagnostic accuracy of 18F-FDG-PET/CT and MRI in predicting the tumor response in locally advanced cervical carcinoma (LACC) treated by chemoradiotherapy (CRT). Method. This meta-analysis has been performed according to PRISMA guidelines. Systematic searches were conducted using PubMed and Embase databases for articles published from January 1, 2010, to January 1, 2020. By using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool, the reviewers assessed the methodological quality scores of the selected studies. We analyzed the sensitivity, specificity, and accuracy of two diagnostic methods using Meta-DiSc 1.4 and Stata 15. Results. An overall of 15 studies including 1132 patients were included. Sensitivities of PET/CT and MRI were 83.5% and 82.7%, while the corresponding rates for specificities were 77.8% and 68.4%, respectively. The DOR, PLR, and NLR for MRI were 15.140, 2.92, and 22.6. PET/CT had a DOR of 25.21. The PLR and NLR for PET/CT were 4.13 and 0.215, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of residual tumor were 86% and 95%, respectively. The corresponding rates for MRI were 73% and 96%, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of tumor metastases were 97% and 99%, while the corresponding rates for MRI were 31% and 98%, respectively. Conclusion. 18F-FDG PET/CT seemed to have a better overall diagnostic accuracy in the evaluation of treatment response to chemoradiotherapy in LACC patients. MRI showed a really poor sensitivity in the detection of metastases, and PET/CT performed significantly better. However, the difference between these two methods in the detection of residual disease was not significant. More studies are needed to be conducted in order to approve that 18F-FDG PET/CT can be a standard option to assess the treatment response.

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