scholarly journals Tolvaptan Response in a Hyponatremic Newborn with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Cengiz Zeybek ◽  
Ali Dinç Bozat ◽  
Erhan Calisici ◽  
Ahmet Bolat ◽  
Belma Saygili Karagol
Keyword(s):  
Antidiuretic Hormone ◽  
Competitive Inhibitor ◽  
Intracranial Hematoma ◽  
Inappropriate Secretion ◽  
Vasopressin V2 Receptor ◽  
V2 Receptor ◽  
Effects On Children

The use of tolvaptan to treat both euvolemic and hypervolemic hyponatremia has rapidly increased in recent years. However, data on its effects on children, especially newborns and infants, are limited. Here, we present a newborn who developed syndrome of inappropriate secretion of antidiuretic hormone following an intracranial hematoma drainage operation who was unresponsive to conventional treatments. The infant was successfully treated with tolvaptan, a competitive inhibitor of the vasopressin V2 receptor.

scholarly journals A Novel Vasopressin Dual V1A/V2 Receptor Antagonist, Conivaptan Hydrochloride, Improves Hyponatremia in Rats with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

2007 ◽  
Vol 30 (1) ◽  
pp. 91-95 ◽  
Author(s):  
Koh-ichi Wada ◽  
Utane Matsukawa ◽  
Akira Fujimori ◽  
Yukinori Arai ◽  
Katsumi Sudoh ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Antidiuretic Hormone ◽  
Inappropriate Secretion ◽  
V2 Receptor ◽  
V2 Receptor Antagonist

scholarly journals Updates and Perspectives on Aquaporin-2 and Water Balance Disorders

2021 ◽  
Vol 22 (23) ◽  
pp. 12950
Author(s):  
Yumi Noda ◽  
Sei Sasaki
Keyword(s):  
Water Balance ◽  
Antidiuretic Hormone ◽  
Water Retention ◽  
Hormone Secretion ◽  
The Body ◽  
Water Reabsorption ◽  
Balance Disorders ◽  
Aquaporin 2 ◽  
Vasopressin V2 Receptor ◽  
V2 Receptor

Ensuring the proper amount of water inside the body is essential for survival. One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2). AQP2 is a channel that is exclusively selective for water molecules and impermeable to ions or other small molecules. Impairments of AQP2 result in various water balance disorders, including nephrogenic diabetes insipidus (NDI), which is a disease characterized by a massive loss of water through the kidney and consequent severe dehydration. Dysregulation of AQP2 is also a cause of water retention with hyponatremia in heart failure, hepatic cirrhosis, and syndrome of inappropriate antidiuretic hormone secretion (SIADH). Antidiuretic hormone vasopressin is an upstream regulator of AQP2. Its binding to the vasopressin V2 receptor promotes AQP2 targeting to the apical membrane and thus enables water reabsorption. Tolvaptan, a vasopressin V2 receptor antagonist, is effective and widely used for water retention with hyponatremia. However, there are no studies showing improvement in hard outcomes or long-term prognosis. A possible reason is that vasopressin receptors have many downstream effects other than AQP2 function. It is expected that the development of drugs that directly target AQP2 may result in increased treatment specificity and effectiveness for water balance disorders. This review summarizes recent progress in studies of AQP2 and drug development challenges for water balance disorders.

Secondary amenorrhea, acute hydrocephalus and syndrome of inappropriate secretion of antidiuretic hormone as first manifestations of neurosarcoidosis

2020 ◽  
Author(s):  
Asma Zargni ◽  
Ibtissem Oueslati ◽  
Aymen Ben Mehrez ◽  
Elyes Kamoun ◽  
Zohra Ben Amor ◽  
...  
Keyword(s):  
Antidiuretic Hormone ◽  
Acute Hydrocephalus ◽  
Secondary Amenorrhea ◽  
Inappropriate Secretion

scholarly journals Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex

2021 ◽  
Vol 7 (21) ◽  
pp. eabg5628
Author(s):  
Julien Bous ◽  
Hélène Orcel ◽  
Nicolas Floquet ◽  
Cédric Leyrat ◽  
Joséphine Lai-Kee-Him ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Antidiuretic Hormone ◽  
Arginine Vasopressin ◽  
Molecular Mechanisms ◽  
Particle Analysis ◽  
Resonance Spectroscopy ◽  
Gpcr Signaling ◽  
Signaling Complex ◽  
Cryo Electron Microscopy ◽  
V2 Receptor

The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2 receptor (V2R) and the Gs protein, promoting kidney water reabsorption. Molecular mechanisms underlying activation of this critical G protein–coupled receptor (GPCR) signaling system are still unknown. To fill this gap of knowledge, we report here the cryo–electron microscopy structure of the AVP-V2R-Gs complex. Single-particle analysis revealed the presence of three different states. The two best maps were combined with computational and nuclear magnetic resonance spectroscopy constraints to reconstruct two structures of the ternary complex. These structures differ in AVP and Gs binding modes. They reveal an original receptor-Gs interface in which the Gαs subunit penetrates deep into the active V2R. The structures help to explain how V2R R137H or R137L/C variants can lead to two severe genetic diseases. Our study provides important structural insights into the function of this clinically relevant GPCR signaling complex.

Inappropriate secretion of antidiuretic hormone in patients with head injuries

1980 ◽  
Vol 82 (4) ◽  
pp. 263-268 ◽  
Author(s):  
A. Twijnstra ◽  
J.M. Minderhoud
Keyword(s):  
Antidiuretic Hormone ◽  
Head Injuries ◽  
Inappropriate Secretion
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