Mechanisms of Tumor Regression and Resistance to Estrogen Deprivation and Fulvestrant in a Model of Estrogen Receptor–Positive, HER-2/neu-Positive Breast Cancer

Her 2 ◽

Abstract 5478: Combination of fulvestrant with the allosteric Akt inhibitor MK-2206 promotes anti-tumor activity in estrogen deprivation-resistant estrogen receptor positive breast cancer

10.1158/1538-7445.am2011-5478 ◽

2011 ◽

Author(s):

Cesar G. Sanchez ◽

Robert J. Crowder ◽

Chanpheng Phommaly ◽

Matthew J. Ellis

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Akt Inhibitor ◽

Estrogen Deprivation ◽

Anti Tumor Activity ◽

Abstract 4415: Differential effects of biochanin A on cell proliferation and ROS-dependent pathways in estrogen receptor positive and HER-2 positive breast cancer cells.

10.1158/1538-7445.am2013-4415 ◽

2013 ◽

Author(s):

Lindsy Dickerson ◽

Vikas Sehdev ◽

Pamela L. Crowell ◽

James C.K. Lai ◽

Alok Bhushan

Keyword(s):

Breast Cancer ◽

Cell Proliferation ◽

Estrogen Receptor ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Biochanin A ◽

Differential Effects ◽

Her 2 ◽

Abstract P3-05-16: The effect of HER-2/neu inhibition on prolonging clinical benefit with fulvestrant treatment for metastatic estrogen receptor positive breast cancer patients treated with trastuzumab

10.1158/1538-7445.sabcs14-p3-05-16 ◽

2015 ◽

Cited By ~ 1

Author(s):

Mahmoud Charif ◽

Elyse E Lower ◽

Diane Kennedy ◽

Harriet Kumar ◽

Shugufta Khan ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Cancer Patients ◽

Clinical Benefit ◽

Breast Cancer Patients ◽

Her 2 ◽

P5-14-18: Today's Estrogen Receptor Positive/Her-2-neu Receptor Negative Breast Cancer Patients Do Significantly Better Than Yesterday's Estrogen Receptor Positive Breast Cancer Patients.

10.1158/0008-5472.sabcs11-p5-14-18 ◽

2011 ◽

Author(s):

EV Madsen ◽

SG Elias ◽

PD Gobardhan ◽

Oort PM van ◽

der Ent FW van ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Her 2 ◽

Better Than ◽

Abstract 2513: NOSH-aspirin alone or in combination with 5-fluorouracil induces tumor regression in a xenograft model of estrogen receptor positive breast cancer

10.1158/1538-7445.am2014-2513 ◽

2014 ◽

Author(s):

Sarin A. Soyemi ◽

Mitali Chattopadhyay ◽

Khosrow Kashfi

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Tumor Regression ◽

Xenograft Model ◽

Progesterone Receptor in Estrogen Receptor–Positive Breast Cancer: The Association Between HER-2 and Lymph Node Involvement Is Age Related

Journal of Clinical Oncology ◽

10.1200/jco.2005.05.1334 ◽

2006 ◽

Vol 24 (16) ◽

pp. 2595-2595 ◽

Cited By ~ 5

Author(s):

Patrick Neven ◽

Nathalie Pochet ◽

Maria Drijkoningen ◽

Frederic Amant ◽

Frank De Smet ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Lymph Node ◽

Progesterone Receptor ◽

Lymph Node Involvement ◽

Age Related ◽

Node Involvement ◽

Her 2 ◽

FGFR1 underlies obesity-associated progression of estrogen receptor–positive breast cancer after estrogen deprivation

JCI Insight ◽

10.1172/jci.insight.120594 ◽

2018 ◽

Vol 3 (14) ◽

Cited By ~ 11

Author(s):

Elizabeth A. Wellberg ◽

Peter Kabos ◽

Austin E. Gillen ◽

Britta M. Jacobsen ◽

Heather M. Brechbuhl ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Estrogen Deprivation ◽

Synthetic lethality when combining phosphoinositide 3-kinase alpha and beta catalytic subunit-directed RNAi and estrogen deprivation for estrogen receptor positive breast cancer: implications for clinical trial design with pharmacological inhibitors.

10.1158/0008-5472.sabcs-3063 ◽

2009 ◽

Author(s):

RJ Crowder ◽

C Phommaly ◽

J Hoog ◽

Y Tao ◽

A Saporita ◽

...

Keyword(s):

Breast Cancer ◽

Clinical Trial ◽

Estrogen Receptor ◽

Trial Design ◽

Synthetic Lethality ◽

Clinical Trial Design ◽

Estrogen Deprivation ◽

Phosphoinositide 3 Kinase ◽

Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

Breast Cancer Research ◽

10.1186/s13058-016-0713-5 ◽

2016 ◽

Vol 18 (1) ◽

Cited By ~ 54

Author(s):

Nikiana Simigdala ◽

Qiong Gao ◽

Sunil Pancholi ◽

Hanne Roberg-Larsen ◽

Marketa Zvelebil ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Cholesterol Biosynthesis ◽

Biosynthesis Pathway ◽

Estrogen Deprivation ◽

Mechanism Of Resistance ◽

Cholesterol Biosynthesis Pathway ◽

PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor–Positive Breast Cancer

Cancer Research ◽

10.1158/0008-5472.can-08-4450 ◽

2009 ◽

Vol 69 (9) ◽

pp. 3955-3962 ◽

Cited By ~ 154

Author(s):

Robert J. Crowder ◽

Chanpheng Phommaly ◽

Yu Tao ◽

Jeremy Hoog ◽

Jingqin Luo ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Synthetic Lethality ◽

Estrogen Deprivation ◽