Characterization of a Novel Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor with a Unique Mechanism of Action for Cancer Therapy

Cancer Research ◽

10.1158/0008-5472.can-08-2627 ◽

2009 ◽

Vol 69 (5) ◽

pp. 1924-1932 ◽

Author(s):

Sherif Daouti ◽

Huisheng Wang ◽

Wen-hui Li ◽

Brian Higgins ◽

Kenneth Kolinsky ◽

...

Keyword(s):

Protein Kinase ◽

Cancer Therapy ◽

Mechanism Of Action ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Unique Mechanism ◽

Protein Kinase Kinase

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Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)36907-7 ◽

1994 ◽

Vol 269 (13) ◽

pp. 9486-9492

Author(s):

H.L. Thompson ◽

C.J. Marshall ◽

J. Saklatvala

Keyword(s):

Protein Kinase ◽

Polymorphonuclear Leukocytes ◽

Mitogen Activated Protein Kinase ◽

Colony Stimulating Factor ◽

Mitogen Activated Protein ◽

Macrophage Colony Stimulating Factor ◽

Macrophage Colony ◽

Stimulating Factor ◽

Protein Kinase Kinase

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Functional characterization of Mitogen-Activated Protein Kinase Kinase (MAPKK) gene in Halophytic Salicornia europaea against salt stress

Environmental and Experimental Botany ◽

10.1016/j.envexpbot.2019.103934 ◽

2020 ◽

Vol 171 ◽

pp. 103934 ◽

Author(s):

Nazia Rehman ◽

Muhammad Ramzan Khan ◽

Zaheer Abbas ◽

Raja Sheraz Rafique ◽

Madiha Zaynab ◽

...

Keyword(s):

Salt Stress ◽

Protein Kinase ◽

Functional Characterization ◽

Mitogen Activated Protein Kinase ◽

Salicornia Europaea ◽

Mitogen Activated Protein ◽

Protein Kinase Kinase

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Characterization of the Mitogen-activated Protein Kinase Kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 Pathways Regulated by MEK Kinases 2 and 3

Journal of Biological Chemistry ◽

10.1074/jbc.272.22.14489 ◽

1997 ◽

Vol 272 (22) ◽

pp. 14489-14496 ◽

Author(s):

Karl Deacon ◽

Jonathan L. Blank

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Protein Kinase Kinase

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Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-1150 ◽

2007 ◽

Vol 13 (5) ◽

pp. 1576-1583 ◽

Author(s):

Tammie C. Yeh ◽

Vivienne Marsh ◽

Bryan A. Bernat ◽

Josh Ballard ◽

Heidi Colwell ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Biological Characterization ◽

Mitogen Activated Protein ◽

Protein Kinase Kinase

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Molecular cloning and characterization of a mitogen-activated protein kinase kinase (OoMAPKK1) in Origanum onites L. (Lamiaceae)

Journal of Plant Biochemistry and Biotechnology ◽

10.1007/s13562-013-0238-2 ◽

2013 ◽

Vol 24 (1) ◽

pp. 75-83 ◽

Author(s):

Ismail Poyraz

Keyword(s):

Protein Kinase ◽

Molecular Cloning ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Protein Kinase Kinase ◽

Origanum Onites

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Characterization of Covalent Pyrazolopyrimidine–MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b00472 ◽

2019 ◽

Vol 62 (11) ◽

pp. 5541-5546 ◽

Author(s):

Patrik Wolle ◽

Julian Engel ◽

Steven Smith ◽

Lisa Goebel ◽

Elisabeth Hennes ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Protein Kinase Kinase

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Isolation and functional characterization of the mitogen-activated protein kinase kinase gene MAPKK1 from Panax notoginseng

European Journal of Plant Pathology ◽

10.1007/s10658-020-01937-7 ◽

2020 ◽

Vol 158 (1) ◽

pp. 1-13

Author(s):

Limei Pu ◽

Rui Chen ◽

Shah Taif ◽

Qin Zhao ◽

Xin Li ◽

...

Keyword(s):

Protein Kinase ◽

Functional Characterization ◽

Panax Notoginseng ◽

Mitogen Activated Protein Kinase ◽

Kinase Gene ◽

Mitogen Activated Protein ◽

Protein Kinase Kinase

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Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-κB1 p105

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2005.06.020 ◽

2005 ◽

Vol 441 (1) ◽

pp. 64-74 ◽

Author(s):

Yong Jia ◽

Christopher M. Quinn ◽

Nancy J. Bump ◽

Kevin M. Clark ◽

Anca Clabbers ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Kinetic Characterization ◽

Mitogen Activated Protein ◽

Cellular Partner ◽

Protein Kinase Kinase

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Molecular cloning and characterization of the mitogen-activated protein kinase kinase gene (MKK4) and its promoter sequence from oilseed rape (Brassica campestris L.)

Plant Cell Tissue and Organ Culture (PCTOC) ◽

10.1007/s11240-013-0366-3 ◽

2013 ◽

Vol 115 (3) ◽

pp. 341-353 ◽

Author(s):

Teng Guo Zhang ◽

Qiong Qiong Chen ◽

Ning Wang ◽

Xiao Hui Xia ◽

Juan Wang ◽

...

Keyword(s):

Protein Kinase ◽

Molecular Cloning ◽

Oilseed Rape ◽

Brassica Campestris ◽

Promoter Sequence ◽

Mitogen Activated Protein Kinase ◽

Kinase Gene ◽

Mitogen Activated Protein ◽

Protein Kinase Kinase

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Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade

Journal of Biological Chemistry ◽

10.1074/jbc.271.19.11427 ◽

1996 ◽

Vol 271 (19) ◽

pp. 11427-11433 ◽

Author(s):

Bernd Stein ◽

Helen Brady ◽

Maria X. Yang ◽

David B. Young ◽

Miguel S. Barbosa

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Kinase Cascade ◽

Protein Kinase Kinase

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