Local-regional recurrence with and without radiation after neoadjuvant chemotherapy and mastectomy for T3N0 breast cancer patients.

2009 ◽  
Author(s):  
H Nagar ◽  
EA Mittendorf ◽  
EA Strom ◽  
G Perkins ◽  
JL Oh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Regional Recurrence ◽  
Breast Cancer Patients ◽  
Local Regional Recurrence

Risk of synchronous distant recurrence at time of local-regional recurrence in stage II and III breast cancer patients.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 6576-6576
Author(s):  
Heather B. Neuman ◽  
Jessica R. Schumacher ◽  
Amanda B. Francescatti ◽  
Taiwo Adesoye ◽  
Stephen B. Edge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Distant Recurrence ◽  
Stage Ii ◽  
Regional Recurrence ◽  
Breast Cancer Patients ◽  
Local Regional Recurrence

scholarly journals The role of postmastectomy radiation in patients with ypN0 breast cancer after neoadjuvant chemotherapy: a meta-analysis

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ke Wang ◽  
Xiaoyan Jin ◽  
Weilan Wang ◽  
Xiuyan Yu ◽  
Jian Huang
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Regional Recurrence ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Postmastectomy Radiation ◽  
Significant Difference ◽  
Local Regional Recurrence

Abstract Background It has been demonstrated that postmastectomy radiation therapy (PMRT) was beneficial for breast cancer patients who are axillary lymph node-positive. However, the effectiveness of radiotherapy in pathological negative nodes (ypN0) after neoadjuvant chemotherapy (NAC) remains open to considerable debate. Here, we aim to evaluate whether PMRT improves loco-regional control and survival for such patients. Methods The literature from January 2004 to June 2019 was searched. The effects of PMRT on local-regional recurrence (LRR) and survival was evaluated in a meta-analysis. Pooled relative risk (RR) values with 95% confidence intervals (CIs) were computed using random and fixed-effect model. Subgroup and heterogeneity analyses were also conducted. Results Twelve studies that included 17,747 patients met the inclusion criteria. Pooled results showed that PMRT was associated with reduced LRR (RR, 0.38; 95% CI, 0.19–0.77, P = 0.007), particularly in patients with stage III breast cancer (RR, 0.16; 95% CI, 0.07–0.37, P < 0.001). However, no significant difference in disease-free survival were observed with the addition of PMRT for ypN0 patients (RR, 0.70; 95% CI, 0.21–2.27, P = 0.55). Also, there was no statistically significant association between radiotherapy with overall survival (RR, 0.81; 95% CI, 0.64–1.04, P = 0.10). Conclusions Our meta-analysis indicated that PMRT might reduce local-regional recurrence for ypN0 patients after NAC, but lack of benefit for survival outcomes. Prospective randomized clinical trial data will be needed to confirm our results.

P087: Loco-regional recurrence rates in breast cancer patients treated with neoadjuvant chemotherapy and breast conserving surgery

2020 ◽  
Vol 46 (6) ◽  
pp. e33-e34
Author(s):  
Marios Konstantinos Tasoulis ◽  
Fiona MacNeill ◽  
Gerald Gui ◽  
Jennifer Rusby ◽  
Katherine Krupa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Breast Conserving Surgery ◽  
Regional Recurrence ◽  
Breast Cancer Patients ◽  
Recurrence Rates

scholarly journals Radiotherapy for and prognosis of breast cancer patients with local-regional recurrence after mastectomy

2009 ◽  
Vol 28 (10) ◽  
pp. 1077-1082
Author(s):  
Jia-Yi Chen ◽  
Xue-Jun Ma ◽  
Wei-Bing Zhou ◽  
Yan Feng ◽  
Guo-Liang Jiang
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Regional Recurrence ◽  
Breast Cancer Patients ◽  
Local Regional Recurrence
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