Abstract B36: Re-activation of protein phosphatase 2A as a multi-target strategy for combating chemotherapy resistance of common cancer types

2012 ◽  
Vol 18 (10 Supplement) ◽  
pp. B36-B36
Author(s):  
Amanpreet Kaur ◽  
Anna Cvrljevic ◽  
Jukka Westermarck
Keyword(s):  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Chemotherapy Resistance ◽  
Common Cancer ◽  
Phosphatase 2A ◽  
Cancer Types ◽  
Target Strategy

Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1

2016 ◽  
Vol 44 (6) ◽  
pp. 1683-1693 ◽  
Author(s):  
Amanpreet Kaur ◽  
Jukka Westermarck
Keyword(s):  
Tumor Suppressor ◽  
Protein Phosphatase ◽  
Kinase Inhibitor ◽  
Protein Phosphatase 2A ◽  
Signaling Proteins ◽  
Tumor Suppressor Function ◽  
Phosphatase 2A ◽  
Cancer Types ◽  
Associated Function ◽  
Inhibitor Resistance

Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.

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