Abstract 2647: Anti-tumor activity of sHA8k, a HYAL1 hyaluronidase inhibitor, in bladder cancer cells

2015 ◽  
Author(s):  
Andre R. Jordan ◽  
Juan Chipollini ◽  
Luis Lopez ◽  
Travis Yates ◽  
Vinata Lokeshwar
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
Hyaluronidase Inhibitor ◽  
Anti Tumor Activity

scholarly journals Daidzein exerts anti-tumor activity against bladder cancer cells via inhibition of FGFR3 pathway

Neoplasma ◽  
2016 ◽  
Vol 63 (04) ◽  
pp. 523-531 ◽  
Author(s):  
Y. HE ◽  
X. WU ◽  
Y. CAO ◽  
Y. HOU ◽  
H. CHEN ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
Anti Tumor Activity

scholarly journals Anti-Tumor Activity and Mechanism of Gemcitabine Derivative SZY-200 Assembled from Gemcitabine-Lauric Acid Conjugate on Human Bladder Cancer Cells

2021 ◽  
Author(s):  
Hongxia Wang ◽  
Zhiyu Shao ◽  
Zhiwen Xu ◽  
Binghao Ye ◽  
Qiaoqiao Zheng ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Lauric Acid ◽  
Cellular Membrane ◽  
Cycle Arrest ◽  
Candidate Drug ◽  
Bladder Cancer Cells ◽  
Acid Conjugate ◽  
Anti Tumor Activity

Abstract Gemcitabine is a first-line drug for the treatment of bladder cancer. One of the most important mechanisms of gemcitabine resistance is the low expression of cellular membrane transporter hENT1. Various derivatives containing fatty acid side chains have been developed in order to facilitate gemcitabine uptake and prolong its retention in cells, such as CP-4126. In this study, the anti-tumor effect and mechanism of a new derivative of gemcitabine named SZY-200 on bladder cancer cells was investigated. SZY-200 was assembled from gemcitabine-lauric acid conjugate. Our data showed that SZY-200 could inhibit the proliferation of bladder cancer cells by inducing cell cycle arrest and apoptosis. The inhibitory effects were comparable to gemcitabine and CP-4126. Importantly, SZY-200 was independent of the membrane transport system in bladder cancer cells. Moreover, we found that lauric acid could also inhibit the proliferation of bladder cancer cells. SZY-200 could downregulate the expressions of PPARG and PTGS2 which were related to the occurrence and development of bladder cancer. Overall, these results indicate that SZY-200 could be an ideal candidate drug for further in vivo investigation.

758: Inflammatory and Anti-Inflammatory Regulators alter Levels of an Inhibitor of Apoptosis (IAP), Survivin, in T-24 Bladder Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 254-254
Author(s):  
Justin J. Cohen ◽  
Bayan T. Takizawa ◽  
Hristos Z. Kaimkliotis ◽  
David J. Rosenberg ◽  
Marcia A. Wheeler ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Inhibitor Of Apoptosis ◽  
Bladder Cancer Cells ◽  
Anti Inflammatory

792: Role of Oxidative Stress in Tumorigenic Potential of Bladder Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 214-215 ◽  
Author(s):  
Daniel Cho ◽  
Xiao Fang Ha ◽  
J. Andre Melendez ◽  
Louis J. Giorgi ◽  
Badar M. Mian
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Tumorigenic Potential ◽  
Bladder Cancer Cells

627: Multitarget Gene Inhibition by Synthetic Nucleic Acids in Bladder Cancer Cells

2006 ◽  
Vol 175 (4S) ◽  
pp. 202-202 ◽  
Author(s):  
Yvonne Burmeister ◽  
Kai Kraemer ◽  
Susanne Fuessel ◽  
Matthias Kotzsch ◽  
Axel Meye ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Nucleic Acids ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
Gene Inhibition

723: Chemokine Receptor CXCR4 Mediates Migration and Invasion of Bladder Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 192-192 ◽  
Author(s):  
Margitta Retz ◽  
Sukhvinder S. Sidhu ◽  
Gregory M. Dolganov ◽  
Jan Lehmann ◽  
Peter R. Carroll ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Chemokine Receptor ◽  
Migration And Invasion ◽  
Chemokine Receptor Cxcr4 ◽  
Bladder Cancer Cells

Pirarubicin inhibits proliferation of bladder cancer cells through PLCε-Bcl-2 pathway

2014 ◽  
Vol 35 (7) ◽  
pp. 708
Author(s):  
Li-ping OU ◽  
Hong-fei DU ◽  
Chang-kun Lv ◽  
Xue-dong SONG ◽  
Yan-ru FAN ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Bladder Cancer Cells
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