Abstract 1387: Target RNA sequencing revealed the expression profile of cancer genes in response to deacetylase inhibitor in primary culture of prostate cancer cells

2017 ◽  
Author(s):  
Hong Yin ◽  
Adam H. Greer ◽  
Glenn Mills
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Primary Culture ◽  
Rna Sequencing ◽  
Expression Profile ◽  
Cancer Genes ◽  
Prostate Cancer Cells ◽  
Deacetylase Inhibitor ◽  
Target Rna

scholarly journals Quantitative expression profile of androgen-regulated genes in prostate cancer cells and identification of prostate-specific genes

2001 ◽  
Vol 92 (3) ◽  
pp. 322-328 ◽  
Author(s):  
Linda L. Xu ◽  
Yong Ping Su ◽  
Ron Labiche ◽  
Takehiko Segawa ◽  
Naga Shanmugam ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Expression Profile ◽  
Prostate Cancer Cells ◽  
Quantitative Expression

scholarly journals RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance

Oncotarget ◽  
2018 ◽  
Vol 9 (54) ◽  
pp. 30363-30384 ◽  
Author(s):  
Christina K. Cajigas-Du Ross ◽  
Shannalee R. Martinez ◽  
Leanne Woods-Burnham ◽  
Alfonso M. Durán ◽  
Sourav Roy ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Rna Sequencing ◽  
Metastatic Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Taxane Resistance

Knockdown of long noncoding RNA AC245100.4 inhibits the tumorigenesis of prostate cancer cells via the STAT3/NR4A3 axis

Epigenomics ◽  
2021 ◽  
Author(s):  
Chi Liu ◽  
Ping Lin ◽  
Jiabin Zhao ◽  
Hui Xie ◽  
Rou Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Rna Sequencing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Transcriptional Repressor ◽  
Sequencing Analysis ◽  
Loss Of Function ◽  
Prostate Cancer Cells ◽  
Rna Immunoprecipitation

Aim: To explore the role and mechanism of long noncoding RNA AC245100.4 and NR4A3 in prostate cancer (PCa). Methods: RNA-sequencing analysis was used to detect the downstream genes of AC245100.4. A series of gain- and loss-of-function approaches were used to investigate the roles of AC245100.4 and NR4A3. RNA immunoprecipitation was performed to examine the interaction between AC245100.4 and STAT3. Results: AC245100.4 was significantly upregulated in PCa cells and tissues. Knockdown of AC21500.4 significantly inhibited the tumorigenesis of PCa cells. Mechanistically, AC245100.4 deregulated the transcription of NR4A3 via increasing p-STAT3, which acted as a transcriptional repressor of NR4A3. Conclusion: Knockdown of lncRNA AC245100.4 inhibits the tumorigenesis of PCa cells via the STAT3/ NR4A3 axis.

Sign in / Sign up

Export Citation Format

Share Document