Abstract 2375: Functional role of the tumor suppressor protein phosphatase, PP2A-B55α, in breast cancer

2017 ◽  
Author(s):  
Nikita Panicker ◽  
Abdul Mannan ◽  
Lauren F. Watt ◽  
Ben Copeland ◽  
Matt D. Dun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Protein Phosphatase ◽  
Functional Role ◽  
Tumor Suppressor Protein

scholarly journals Rewired Notch/p53 by Numb’ing Mdm2

2018 ◽  
Vol 217 (2) ◽  
pp. 445-446 ◽  
Author(s):  
Hyungsoo Kim ◽  
Ze’ev A. Ronai
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Therapeutic Intervention ◽  
Splice Variant ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53 ◽  
Cell Biol ◽  
Coordinated Regulation

Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53–Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a newly characterized Numb splice variant in the regulation of p53, which may have significant implications for therapeutic intervention in breast cancer.

scholarly journals Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications

2016 ◽  
Vol 36 (12) ◽  
pp. 1734-1739 ◽  
Author(s):  
Ion Cristóbal ◽  
Federico Rojo ◽  
Juan Madoz-Gúrpide ◽  
Jesús García-Foncillas
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Tumor Suppressor ◽  
Cross Talk ◽  
Protein Phosphatase ◽  
Tumor Suppressor Protein ◽  
Therapeutic Implications ◽  
Functional Implications ◽  
Phosphatase 2A

Aberrant activation of the Wnt/β-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signaling regulators and the pivotal role of the tumor suppressor protein phosphatase 2A (PP2A) modulating these pathways.

scholarly journals Assessing the functional role of caspase-8 gene variants in breast cancer

2010 ◽  
Vol 12 (S1) ◽  
Author(s):  
SH Rigas ◽  
M Parry ◽  
MW Reed ◽  
N Camp ◽  
A Cox
Keyword(s):  
Breast Cancer ◽  
Functional Role ◽  
Caspase 8 ◽  
Gene Variants
Sign in / Sign up

Export Citation Format

Share Document