scholarly journals Abstract 4694: Evaluation of tumor-associated antigen expression with the MACSimaTMhigh-content imaging platform

2019 ◽  
Author(s):  
Christoph Herbel ◽  
Vera Dittmer ◽  
Manuel Martinez-Osuna ◽  
Laura Nadine Kuester ◽  
Daniel Schaefer ◽  
...  
Keyword(s):  
Antigen Expression ◽  
Tumor Associated Antigen

Cell Kinetics and Tumor-Associated Antigen Expression in Human Mammary Carcinomas

1991 ◽  
Vol 6 (3) ◽  
pp. 159-166 ◽  
Author(s):  
A. Contegiacomo ◽  
R. Mariani Costantini ◽  
R. Muraro ◽  
P. Battista ◽  
C. Valli ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Proliferative Activity ◽  
Antigen Expression ◽  
Breast Carcinomas ◽  
Cellular Kinetics ◽  
Tumor Associated Antigen ◽  
Antigenic Expression ◽  
High Proliferative Activity ◽  
Antigenic Phenotype ◽  
Intense Immunoreactivity

Twenty-six primary breast carcinomas were studied to evaluate cell proliferation as assessed by thymidine labeling index (TLI), and antigenic phenotype, as defined by immunohistochemistry using eight monoclonal antibodies (MAbs) to tumor-associated antigens (TAAs). The majority of tumors had low TLI values. Reactivity to MAbs B72.3, CC49, CC83 (anti TAG 72), COL-12 (anti CEA) and MOv2 (against a tumor-associated mucoprotein) was restricted to < 50% of the tumors studied, while MAbs B1.1 (anti CEA), MBrl and MBr8 (to tumor-associated carbohydrates) reacted with > 50% of the cases. Correlations between expression of TAAs and proliferative activity showed that the tumors could be divided into three groups, two characterized by either high proliferative activity and absence of antigenic expression or low proliferative activity and strong antigenic expression, and the third showing no relation between these two biological features. We defined two antigenic phenotypes associated with specific cellular kinetics: one characterized by negative immunoreaction with MAbs, CC49, CC83 and COL-12 and high proliferative activity; the other characterized by intense immunoreactivity with these antibodies and low proliferative activity. The data suggest that cell proliferation and antigenic phenotype may define biologic subsets of breast carcinomas

scholarly journals Elevated Tumor-Associated Antigen Expression Suppresses Variant Peptide Vaccine Responses

2011 ◽  
Vol 187 (9) ◽  
pp. 4431-4439 ◽  
Author(s):  
Charles B. Kemmler ◽  
Eric T. Clambey ◽  
Ross M. Kedl ◽  
Jill E. Slansky
Keyword(s):  
Peptide Vaccine ◽  
Antigen Expression ◽  
Vaccine Responses ◽  
Tumor Associated Antigen ◽  
Variant Peptide

Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population

2012 ◽  
Vol 92 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Takashi Mori ◽  
Satoshi Nishizawa ◽  
Yoshihiko Hirohashi ◽  
Toshihiko Torigoe ◽  
Yasuaki Tamura ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Antigen Expression ◽  
Tumor Associated Antigen

Modulation of tumor associated antigen expression and shedding by recombinant human leukocyte and fibroblast interferons

1985 ◽  
Vol 31 (3) ◽  
pp. 209-236 ◽  
Author(s):  
John W. Greiner ◽  
Jeffrey Schlom ◽  
Sidney Pestka ◽  
Jerome A. Langer ◽  
Patrizio Giacomini ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Antigen Expression ◽  
Tumor Associated Antigen

Tissue Microarray Evaluation of Melanoma Antigen E (MAGE) Tumor-Associated Antigen Expression

2002 ◽  
Vol 236 (6) ◽  
pp. 785-793 ◽  
Author(s):  
Martin Bolli ◽  
Thomas Kocher ◽  
Michel Adamina ◽  
Ulrich Guller ◽  
Peter Dalquen ◽  
...  
Keyword(s):  
Tissue Microarray ◽  
Antigen Expression ◽  
Melanoma Antigen ◽  
Tumor Associated Antigen

Role of tumor-associated antigen expression in radioimmunoguided surgery for colorectal and breast cancer

1998 ◽  
Vol 15 (4) ◽  
pp. 249-253 ◽  
Author(s):  
Sergio Bertoglio ◽  
Pierluigi Percivale ◽  
Federico Schenone ◽  
Alberto Peressini ◽  
Carmelina Murolo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antigen Expression ◽  
Radioimmunoguided Surgery ◽  
Tumor Associated Antigen

Tumor-Associated Antigen Expression of Primary and Metastatic Colon Carcinomas Detected by Monoclonal Antibody 17-1A

1987 ◽  
Vol 88 (4) ◽  
pp. 462-467 ◽  
Author(s):  
Rose A. Goodwin ◽  
Steven E. Tuttle ◽  
Donna M. Bucci ◽  
Scott D. Jewell ◽  
Edward W. Martin ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Antigen Expression ◽  
Tumor Associated Antigen
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