Abstract 3419: Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immunosuppression

2020 ◽  
Author(s):  
Nathan E. Reticker-Flynn ◽  
Pamela A. Basto ◽  
Weiruo Zhang ◽  
Maria M. Martins ◽  
Serena Chang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Metastasis ◽  
Distant Tumor ◽  
Specific Immunosuppression

Abstract PR007: Lymph node colonization promotes distant tumor metastasis through the induction of systemic tumor-specific immunosuppression

2021 ◽  
Author(s):  
Nathan E. Reticker-Flynn ◽  
Weiruo Zhang ◽  
Serena Chang ◽  
Andrew J. Gentles ◽  
John B. Sunwoo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Metastasis ◽  
Distant Tumor ◽  
Specific Immunosuppression

Abstract PR04: Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immunosuppression

2020 ◽  
Author(s):  
Nathan E. Reticker-Flynn ◽  
Pamela A. Basto ◽  
Weiruo Zhang ◽  
Alborz Bejnood ◽  
Justin A. Kenkel ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Metastasis ◽  
Distant Tumor ◽  
Specific Immunosuppression

Abstract 2703: Lymph node colonization promotes distant tumor metastasis through the induction of systemic immune tolerance

2019 ◽  
Author(s):  
Nathan E. Reticker-Flynn ◽  
Maria M. Martins ◽  
Pamela A. Basto ◽  
Weiruo Zhang ◽  
Alborz Bejnood ◽  
...  
Keyword(s):  
Lymph Node ◽  
Immune Tolerance ◽  
Tumor Metastasis ◽  
Distant Tumor

Abstract PR05: Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immune tolerance

2022 ◽  
Author(s):  
Nathan E. Reticker-Flynn ◽  
Weiruo Zhang ◽  
Julia A. Belk ◽  
Andrew J. Gentles ◽  
Ansuman Satpathy ◽  
...  
Keyword(s):  
Lymph Node ◽  
Immune Tolerance ◽  
Tumor Metastasis ◽  
Distant Tumor

Abstract 2703: Lymph node colonization promotes distant tumor metastasis through the induction of systemic immune tolerance

2019 ◽  
Author(s):  
Nathan E. Reticker-Flynn ◽  
Maria M. Martins ◽  
Pamela A. Basto ◽  
Weiruo Zhang ◽  
Alborz Bejnood ◽  
...  
Keyword(s):  
Lymph Node ◽  
Immune Tolerance ◽  
Tumor Metastasis ◽  
Distant Tumor

Erythropoietin Induces Lymph Node Lymphangiogenesis and Lymph Node Tumor Metastasis

2011 ◽  
Vol 71 (13) ◽  
pp. 4506-4517 ◽  
Author(s):  
Ae Sin Lee ◽  
Duk Hoon Kim ◽  
Jung Eun Lee ◽  
Yu Jin Jung ◽  
Kyung Pyo Kang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Metastasis

scholarly journals Association of CD44−/CD24− Breast Cancer Cells with Late Stage Tumor Recurrence

2020 ◽  
Author(s):  
Xinbo Qiao ◽  
Yixiao Zhang ◽  
Lisha Sun ◽  
Qingtian Ma ◽  
Jie Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Tumor Metastasis ◽  
Cancer Prognosis ◽  
Molecular Events ◽  
Cell Conversion ◽  
Tissue Specimens ◽  
Distant Tumor

AbstractTumor metastasis remains the main cause of breast cancer-related deaths, especially the later breast cancer distant metastasis. This study assessed CD44−/CD24− tumor cells in 576 tissue specimens for associations with clinicopathological features and metastasis and then investigated the underlying molecular events. The data showed that level of CD44−/CD24− cells was associated with later postoperative distant tumor metastasis. Furthermore, CD44−/CD24− triple negative cells could spontaneously convert into CD44+/CD24− cancer stem cells (CSCs) with properties similar to CD44+/CD24− CSCs from parental MDA-MB-231 cells in terms of gene expression, tumor cell xenograft formation, and lung metastasis in vitro and in vivo. Single-cell RNA sequencing identified RHBDL2 as a regulator that enhanced spontaneous CD44+/CD24− CSC conversion, whereas knockdown of RHBDL2 expression inhibited YAP/NF-κB signaling and blocked spontaneous CD44−/CD24− cell conversion to CSCs. These data suggested that the level of CD44−/CD24− tumor cells could predict breast cancer prognosis, metastasis, and response to adjuvant therapy.

scholarly journals VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

2005 ◽  
Vol 201 (7) ◽  
pp. 1089-1099 ◽  
Author(s):  
Satoshi Hirakawa ◽  
Shohta Kodama ◽  
Rainer Kunstfeld ◽  
Kentaro Kajiya ◽  
Lawrence F. Brown ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Lymphatic Metastasis ◽  
Tumor Metastasis ◽  
Fluorescent Protein ◽  
Sentinel Lymph Nodes ◽  
Skin Carcinogenesis ◽  
Vegf Receptor ◽  
Primary Tumors

The mechanisms of tumor metastasis to the sentinel lymph nodes are poorly understood. Vascular endothelial growth factor (VEGF)-A plays a principle role in tumor progression and angiogenesis; however, its role in tumor-associated lymphangiogenesis and lymphatic metastasis has remained unclear. We created transgenic mice that overexpress VEGF-A and green fluorescent protein specifically in the skin, and subjected them to a standard chemically-induced skin carcinogenesis regimen. We found that VEGF-A not only strongly promotes multistep skin carcinogenesis, but also induces active proliferation of VEGF receptor-2–expressing tumor-associated lymphatic vessels as well as tumor metastasis to the sentinel and distant lymph nodes. The lymphangiogenic activity of VEGF-A–expressing tumor cells was maintained within metastasis-containing lymph nodes. The most surprising finding of our study was that even before metastasizing, VEGF-A–overexpressing primary tumors induced sentinel lymph node lymphangiogenesis. This suggests that primary tumors might begin preparing their future metastatic site by producing lymphangiogenic factors that mediate their efficient transport to sentinel lymph nodes. This newly identified mechanism of inducing lymph node lymphangiogenesis likely contributes to tumor metastasis, and therefore, represents a new therapeutic target for advanced cancer and/or for the prevention of metastasis.

scholarly journals Fatty acid oxidation: driver of lymph node metastasis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mao Li ◽  
Hong-chun Xian ◽  
Ya-Jie Tang ◽  
Xin-hua Liang ◽  
Ya-ling Tang
Keyword(s):  
Lymph Node ◽  
Fatty Acid ◽  
Lymph Node Metastasis ◽  
Tumor Cells ◽  
Fatty Acid Oxidation ◽  
Tumor Metastasis ◽  
Cancer Metabolism ◽  
Acid Oxidation ◽  
Node Metastasis

AbstractFatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasis, is much indispensable for grasping tumor progression, formulating therapy measure and evaluating tumor prognosis. There is a plethora of studies showing different ways how tumor cells metastasize to the lymph nodes, but the role of FAO in lymph node metastasis remains largely unknown. Here, we summarize recent findings and update the current understanding that FAO may enable lymph node metastasis formation. Afterward, it will open innovative possibilities to present a distinct therapy of targeting FAO, the metabolic rewiring of cancer to terminal cancer patients.

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