Abstract PD7-04: Contribution of radiation therapy to the overall cost of cancer care for clinical stage IA breast cancer patients

Author(s):  
T Dvorak ◽  
D Coltey ◽  
J Waters ◽  
P Kelly ◽  
D Buchholz
2018 ◽  
Vol 84 (5) ◽  
pp. 620-627 ◽  
Author(s):  
Elena P. Lamb ◽  
F. Elizabeth Pritchard ◽  
Simonne S. Nouer ◽  
Elizabeth A. Tolley ◽  
Brandon S. Boyd ◽  
...  

Although significant progress has been made in improving breast cancer survival, disparities among racial, ethnic, and underserved groups still exist. The goal of this investigation is to quantify racial disparities in the context of breast cancer care, examining the outcomes of recurrence and mortality in the city of Memphis. Patients with a biopsy-proven diagnosis of breast cancer from January 1, 2002, through December 31, 2012, were obtained from the tumor registry. Black patients were more likely to have advanced (II, III, or IV) clinical stage of breast cancer at diagnosis versus white patients. Black breast cancer patients had a two times higher odds of recurrence (95% confidence interval: 1.4, 3.0) after adjusting for race and clinical stage. Black breast cancer patients were 1.5 times more likely to die (95% confidence interval: 1.2, 1.8), after adjusting for race; age at diagnosis; clinical stage; ER, PR, HER2 status; and recurrence. Black women with stages 0, I, II, and III breast cancer all had a statistically significant longer median time from diagnosis to surgery than white women. Black patients were more likely to have advanced clinical stages of breast cancer at diagnosis versus white patients on a citywide level in Memphis. Black breast cancer patients have higher odds of recurrence and mortality when compared with white breast cancer patients, after adjusting for appropriate demographic and clinical attributes. More work is needed to develop, evaluate, and disseminate interventions to decrease inequities in timeliness of care for breast cancer patients.


2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 81s-81s
Author(s):  
S. Chillakunnel Hussain Rawther ◽  
M. Shivananda Pai ◽  
D. Fernandes

Background: Breast cancer incidences in India are rapidly rising, amounting to a significant percentage of all cancers in women. The diagnosis and expenses for treatment make the patient to thrust on a journey that disorganizes their daily function and family roles with much fear and uncertainty. The care of the patients requires a comprehensive individualized care from a pivotal nurse to meet their informational and educational needs, support, and care coordination throughout their illness trajectory. Limited studies have been reported from developing countries on specific nursing roles in cancer care. Therefore, the researcher felt the need for developing a nurse navigation program for the care of breast cancer patients. Aim: The aim of the study was to develop, validate and assess the usefulness of the program in women with breast cancer. Methods: The content of Nurse Navigator Program was prepared by reviewing literature pertaining to nurse/patient navigation programs. The program has been validated by an expert committee consisting of experts from various fields. The program consists of preoperative education on surgery and postmastectomy care, progressive muscle relaxation training, information booklets on post mastectomy care, chemotherapy and radiation therapy, telephonic follow-up sessions and ONN visits. Readability testing of the information booklets was checked online by Flesch reading ease and Flesch Kincaid-Grade level. The educational program and information booklets were translated into Kannada and retranslated into English with help of 2 experts. Researcher had undergone training in progressive muscle relaxation. Finally the usefulness and acceptability of the program was tested in 60 breast cancer patients undergoing surgery followed by chemo/radiation therapy in surgery, chemo and radiotherapy wards of a tertiary care hospital in Karnataka. After obtaining ethical permission from institutional ethical committee written informed consent was obtained from participants before conducting study. Results: The mean ICVI, SCVI/UA and mean expert proportion of the Nurse Navigator Program was found to be −1.00 for each. Flesch reading ease was 77.3 and Flesch Kincaid-Grade level achieved was 4.8. 83.3% of women strongly agreed that information booklets were useful, 80% strongly agreed the user friendliness of this program & 70% of people reported that their emotional needs were taken care seriously and got additional emotional support. 90% strongly agreed navigation services are necessary and would recommend navigation service. Conclusion: The validated Nurse Navigator Program was found acceptable and useful for patients. The whole program may give evidence on the effectiveness of a nurse navigator program for the care of women with breast cancer. If significant effects are detected this program could be implemented in the hospital setting to improve cancer care.


2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.


2006 ◽  
Vol 117 (2) ◽  
pp. 359-365 ◽  
Author(s):  
Jeffrey A. Ascherman ◽  
Matthew M. Hanasono ◽  
Martin I. Newman ◽  
Duncan B. Hughes

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