Abstract 365: Indotecan (LMP400), indimitecan (LMP776) and LMP744, a new class of non-camptothecin topoisomerase I inhibitors selective for schlafen11-positive and BRCA-deficient cells that synergize with olaparib

2019 ◽  
Author(s):  
Laetitia Marzi ◽  
Ludmila Szabova ◽  
Zoe Weaver Ohler ◽  
Shyam Sharan ◽  
Mike Beshiri ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
New Class ◽  
Topoisomerase I Inhibitors

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

2021 ◽  
Vol 215 ◽  
pp. 113261
Author(s):  
Mostafa M. Elbadawi ◽  
Wagdy M. Eldehna ◽  
Wenjie Wang ◽  
Keli K. Agama ◽  
Yves Pommier ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Topoisomerase I ◽  
New Class ◽  
Topoisomerase I Inhibitors

Naphtho[2,3-f]indole-5,10-dione aminoalkyl derivatives: A new class of topoisomerase I inhibitors

2008 ◽  
Vol 145 (3) ◽  
pp. 334-337 ◽  
Author(s):  
L. G. Dezhenkova ◽  
O. Yu. Susova ◽  
A. E. Shchekotikhin ◽  
M. N. Preobrazhenskaya ◽  
A. A. Shtil
Keyword(s):  
Topoisomerase I ◽  
New Class ◽  
Topoisomerase I Inhibitors

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

2015 ◽  
Vol 14 (23) ◽  
pp. 2722-2728 ◽  
Author(s):  
Concepcion Alonso ◽  
Maria Fuertes ◽  
Maria Gonzalez ◽  
Alicia Rodriguez-Gascon ◽  
Gloria Rubiales ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Biological Evaluation ◽  
Antiproliferative Agents ◽  
Topoisomerase I Inhibitors ◽  
New Family ◽  
Synthesis And Biological Evaluation

Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

2017 ◽  
Vol 13 (3) ◽  
Author(s):  
Balazs Balogh ◽  
Anna Carbone ◽  
Virginia Spanò ◽  
Alessandra Montalbano ◽  
Paola Barraja ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Topoisomerase I ◽  
Modeling Methods ◽  
Topoisomerase I Inhibitors

Radiation lethality enhancement with 9-aminocamptothecin: Comparison to other topoisomerase I inhibitors

1996 ◽  
Vol 36 (2) ◽  
pp. 369-376 ◽  
Author(s):  
John P. Lamond ◽  
Meizhi Wang ◽  
Timothy J. Kinsella ◽  
David A. Boothman
Keyword(s):  
Topoisomerase I ◽  
Topoisomerase I Inhibitors
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