scholarly journals EphB4 Promotes Site-Specific Metastatic Tumor Cell Dissemination by Interacting with Endothelial Cell–Expressed EphrinB2

2010 ◽  
Vol 8 (10) ◽  
pp. 1297-1309 ◽  
Author(s):  
Mélanie Héroult ◽  
Florence Schaffner ◽  
Dennis Pfaff ◽  
Claudia Prahst ◽  
Robert Kirmse ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Tumor Cell ◽  
Metastatic Tumor ◽  
Tumor Cell Dissemination ◽  
Site Specific ◽  
Metastatic Tumor Cell ◽  
Cell Dissemination

Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice

Science ◽  
2018 ◽  
Vol 359 (6382) ◽  
pp. 1408-1411 ◽  
Author(s):  
M. Brown ◽  
F. P. Assen ◽  
A. Leithner ◽  
J. Abe ◽  
H. Schachner ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Cell ◽  
Blood Vessels ◽  
Metastatic Tumor ◽  
Tumor Cell Dissemination ◽  
Metastatic Tumor Cell ◽  
Cell Dissemination

scholarly journals A Disaccharide-Based Inhibitor of Glycosylation Attenuates Metastatic Tumor Cell Dissemination

2006 ◽  
Vol 12 (9) ◽  
pp. 2894-2901 ◽  
Author(s):  
Jillian R. Brown ◽  
Mark M. Fuster ◽  
Ruixia Li ◽  
Nissi Varki ◽  
Charles A. Glass ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Metastatic Tumor ◽  
Tumor Cell Dissemination ◽  
Metastatic Tumor Cell ◽  
Cell Dissemination

scholarly journals Metastatic tumor cell attachment and invasion assay utilizing vascular endothelial cell monolayers.

1982 ◽  
Vol 30 (3) ◽  
pp. 214-220 ◽  
Author(s):  
G L Nicolson
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Tumor Cell ◽  
Basal Lamina ◽  
Cell Monolayer ◽  
Vascular Endothelial Cell ◽  
Metastatic Tumor ◽  
Vascular Endothelial ◽  
Metastatic Tumor Cell

Two of the more important steps in blood-borne tumor metastasis are attachment of the circulating malignant cells to the vascular endothelium and subsequent extravasation or invasion out of the blood vessel. A model for this process has been developed using cultured monolayers of vascular endothelial cells that synthesize a basal lamina or extracellular matrix (Kramer and Nicolson, Proc Natl Acad Sci USA 76:504, 1979). We have used this model to study metastatic tumor cell-endothelial cell interactions such as attachment to endothelial cells and their subsequent retraction and exposure of endothelial basal lamina as well as the interactions of metastatic tumor cells with the basal lamina leading to invasion and solubilization of this extracellular matrix. Morphological, immunological, and enzymological analysis of these steps in the metastatic process can be obtained using the vascular endothelial cell monolayer model for attachment and invasion.

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