Possible Role of Visfatin in Hepatoma Progression and the Effects of Branched-Chain Amino Acids on Visfatin-Induced Proliferation in Human Hepatoma Cells

2011 ◽  
Vol 4 (12) ◽  
pp. 2092-2100 ◽  
Author(s):  
Soranobu Ninomiya ◽  
Masahito Shimizu ◽  
Kenji Imai ◽  
Koji Takai ◽  
Makoto Shiraki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Branched Chain

Combination of acyclic retinoid with branched-chain amino acids inhibits xenograft growth of human hepatoma cells in nude mice

2012 ◽  
Vol 42 (12) ◽  
pp. 1241-1247 ◽  
Author(s):  
Masahito Shimizu ◽  
Yohei Shirakami ◽  
Hiroyasu Sakai ◽  
Junpei Iwasa ◽  
Makoto Shiraki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Nude Mice ◽  
Branched Chain Amino Acids ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Xenograft Growth ◽  
Acyclic Retinoid ◽  
Branched Chain

scholarly journals Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial

2016 ◽  
Vol 62 (4) ◽  
pp. 582-592 ◽  
Author(s):  
Miguel Ruiz-Canela ◽  
Estefania Toledo ◽  
Clary B Clish ◽  
Adela Hruby ◽  
Liming Liang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Amino Acids ◽  
Cardiovascular Death ◽  
Branched Chain Amino Acids ◽  
Control Group ◽  
Cvd Risk ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Branched Chain

Abstract BACKGROUND The role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODS We developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTS After adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05–2.76) and 2.09 (1.27–3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across successive quartiles of BCAAs in the control group than in the MedDiet groups. With stroke as the outcome, a significant interaction (P = 0.009) between baseline BCAA score and intervention with MedDiet was observed. No significant effect of the intervention on 1-year changes in BCAAs or any association between 1-year changes in BCAAs and CVD were observed. CONCLUSIONS Higher concentrations of baseline BCAAs were associated with increased risk of CVD, especially stroke, in a high cardiovascular risk population. A Mediterranean-style diet had a negligible effect on 1-year changes in BCAAs, but it may counteract the harmful effects of BCAAs on stroke.

Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells

2001 ◽  
Vol 188 (2) ◽  
pp. 188-193 ◽  
Author(s):  
Hui-Chiu Chang ◽  
Li-Huang Tsai ◽  
Lea-Yea Chuang ◽  
Wen-Chun Hung
Keyword(s):  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Akt Kinase ◽  
Induced Apoptosis

scholarly journals From mitochondria to healthy aging: The role of branched-chain amino acids treatment: MATeR a randomized study

2020 ◽  
Vol 39 (7) ◽  
pp. 2080-2091 ◽  
Author(s):  
Ilaria Buondonno ◽  
Francesca Sassi ◽  
Giulia Carignano ◽  
Francesca Dutto ◽  
Cinzia Ferreri ◽  
...  
Keyword(s):  
Amino Acids ◽  
Healthy Aging ◽  
Randomized Study ◽  
Branched Chain Amino Acids ◽  
Branched Chain

Abstract 3423: The role of PGC1-α and KLF4 in inhibiting the progression of human hepatoma cells

2011 ◽  
Author(s):  
Chin-Wen Chi ◽  
Ming-Ta Sung ◽  
Ann-Tin Ho ◽  
Chin-Chun Lee ◽  
Wei-Shan Tu ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

Amino acid transportation, sensing and signal transduction in the mammary gland: key molecular signalling pathways in the regulation of milk synthesis

2020 ◽  
Vol 33 (2) ◽  
pp. 287-297
Author(s):  
Zhihui Wu ◽  
Jinghui Heng ◽  
Min Tian ◽  
Hanqing Song ◽  
Fang Chen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Mammary Gland ◽  
Milk Protein ◽  
Building Blocks ◽  
Branched Chain Amino Acids ◽  
Signalling Pathways ◽  
Recent Advances ◽  
Branched Chain ◽  
Molecular Signalling Pathways

AbstractThe mammary gland, a unique exocrine organ, is responsible for milk synthesis in mammals. Neonatal growth and health are predominantly determined by quality and quantity of milk production. Amino acids are crucial maternal nutrients that are the building blocks for milk protein and are potential energy sources for neonates. Recent advances made regarding the mammary gland further demonstrate that some functional amino acids also regulate milk protein and fat synthesis through distinct intracellular and extracellular pathways. In the present study, we discuss recent advances in the role of amino acids (especially branched-chain amino acids, methionine, arginine and lysine) in the regulation of milk synthesis. The present review also addresses the crucial questions of how amino acids are transported, sensed and transduced in the mammary gland.

The role of alpha-fetoprotein in maintaining the growth of human hepatoma cells

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14081-14081
Author(s):  
M. Li ◽  
S. Zhou ◽  
X. Liu ◽  
G. Li
Keyword(s):  
Confocal Microscopy ◽  
Caspase 3 ◽  
Immune Surveillance ◽  
Hepatoma Cells ◽  
Alpha Fetoprotein ◽  
Jurkat Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Apoptosis Related Gene

14081 Background: This study was to explored the functional mechanism of alpha-fetoprotein (AFP) in maintaining the proliferation of human hepatoma cells line Bel 7402 and the immunsuppression of lymphocyte Jurkat cells. Methods: Western blot was used to detecting the expression of some apoptosis-related gene, fluorescence labeled AFP and confocal microscopy scanning for receptor binding assay in the membrane in Jurkat cells. Results: It showed that AFP could enhance the expression of survivin and c-ras, but restrain caspase-3 express in Bel 7402 cells by Western blotting analysis. It also showed that AFP could bind to the membrane of Jurkat cells by confocal microscopy scanning, and when treated Jurkat with AFP, it indicated that AFP could repress the expression of survivin and Livin and elevated the activity of caspase-3 in the cells; Co-cultured Bel 7402 cells with Jurkat cells, the expression of tumor necrosis related-apoptosis induced ligand (TRAIL) in Jurkt cells was inhibited, when pretreatment with monoclonal antibody of AFP (Anti-AFP), the restrained effect of TRAIL express and the activity of caspase-3 was elevated in Jurkat cells was removed. It also indicated that Anti-AFP had an ability to block these functions of AFP. Conclusions: AFP has a capability to promote the growth and escape from immune surveillance of human hepatoma cells through enhancing the expression of ras and survivin gene in Bel 7402 cells, suppressing TRAIL, survivin and Livin expressed and upregulated activity of caspase-3 in Jurkat cells. No significant financial relationships to disclose.

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