MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Nikhil Wagle; Eliezer M. Van Allen; Daniel J. Treacy; Dennie T. Frederick; Zachary A. Cooper; Amaro Taylor-Weiner; Mara Rosenberg; Eva M. Goetz; Ryan J. Sullivan; Deborah N. Farlow; Dennis C. Friedrich; Kristin Anderka; Danielle Perrin; Cory M. Johannessen; Aaron McKenna; Kristian Cibulskis; Gregory Kryukov; Eran Hodis; Donald P. Lawrence; Sheila Fisher; Gad Getz; Stacey B. Gabriel; Scott L. Carter; Keith T. Flaherty; Jennifer A. Wargo; Levi A. Garraway

doi:10.1158/2159-8290.cd-13-0631

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Cancer Discovery ◽

10.1158/2159-8290.cd-13-0631 ◽

2013 ◽

Vol 4 (1) ◽

pp. 61-68 ◽

Cited By ~ 307

Author(s):

Nikhil Wagle ◽

Eliezer M. Van Allen ◽

Daniel J. Treacy ◽

Dennie T. Frederick ◽

Zachary A. Cooper ◽

...

Keyword(s):

Map Kinase ◽

Acquired Resistance ◽

Mek Inhibition ◽

Melanoma Patients ◽

Map Kinase Pathway ◽

Braf Mutant ◽

Kinase Pathway

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Faculty Opinions recommendation of MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718184867.793510328 ◽

2015 ◽

Author(s):

Elaine Mardis

Keyword(s):

Map Kinase ◽

Acquired Resistance ◽

Mek Inhibition ◽

Melanoma Patients ◽

Map Kinase Pathway ◽

Braf Mutant ◽

Kinase Pathway

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Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma

PLoS ONE ◽

10.1371/journal.pone.0138210 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0138210 ◽

Cited By ~ 5

Author(s):

Brian J. Capaldo ◽

Devin Roller ◽

Mark J. Axelrod ◽

Alex F. Koeppel ◽

Emanuel F. Petricoin ◽

...

Keyword(s):

Map Kinase ◽

Systems Analysis ◽

Adaptive Responses ◽

Map Kinase Pathway ◽

Braf Mutant ◽

Kinase Pathway

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Abstract CN07-01: Monitoring downstream responses to MAP kinase pathway inhibitor therapy in BRAF mutant melanoma to support rational combinations strategies.

10.1158/1535-7163.targ-13-cn07-01 ◽

2013 ◽

Author(s):

Keith Thomas Flaherty

Keyword(s):

Map Kinase ◽

Inhibitor Therapy ◽

Map Kinase Pathway ◽

Braf Mutant ◽

Kinase Pathway

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Suppression of BRAF/MEK/MAP Kinase Pathway Restores Expression of Iodide-Metabolizing Genes in Thyroid Cells Expressing the V600E BRAF Mutant

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-1753 ◽

2007 ◽

Vol 13 (4) ◽

pp. 1341-1349 ◽

Cited By ~ 113

Author(s):

D. Liu ◽

S. Hu ◽

P. Hou ◽

D. Jiang ◽

S. Condouris ◽

...

Keyword(s):

Map Kinase ◽

Thyroid Cells ◽

Map Kinase Pathway ◽

Braf Mutant ◽

Kinase Pathway

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577: The RAF/MAP Kinase Pathway Influences Survival in Androgen-Insensitive Prostate Cancer

The Journal of Urology ◽

10.1016/s0022-5347(18)34817-1 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 157-158

Author(s):

Rono Mukherjee ◽

Sarath K. Nalagatla ◽

Mark A. Undenvood ◽

John M.S. Bartlett ◽

Joanne Edwards

Keyword(s):

Prostate Cancer ◽

Map Kinase ◽

Map Kinase Pathway ◽

Kinase Pathway

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Faculty Opinions recommendation of Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1000568.16208 ◽

2001 ◽

Author(s):

Anjana Rao

Keyword(s):

Calcium Channel ◽

Map Kinase ◽

Map Kinase Pathway ◽

Kinase Pathway

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Faculty Opinions recommendation of Control of signaling in a MAP-kinase pathway by an RNA-binding protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1068810.521743 ◽

2007 ◽

Author(s):

Jürg Bahler

Keyword(s):

Map Kinase ◽

Rna Binding ◽

Binding Protein ◽

Rna Binding Protein ◽

Map Kinase Pathway ◽

Kinase Pathway

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Faculty Opinions recommendation of Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1104386.562048 ◽

2008 ◽

Author(s):

Francesc Posas

Keyword(s):

Map Kinase ◽

Signaling Dynamics ◽

Map Kinase Pathway ◽

Kinase Pathway

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Faculty Opinions recommendation of Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1104386.560882 ◽

2008 ◽

Author(s):

Philip Tsichlis

Keyword(s):

Map Kinase ◽

Signaling Dynamics ◽

Map Kinase Pathway ◽

Kinase Pathway

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Lipopolysaccharide upregulates the expression of corticotropin-releasing hormone via MAP kinase pathway in rat peritoneal macrophages

Molecular and Cellular Biochemistry ◽

10.1007/s11010-011-1080-2 ◽

2011 ◽

Vol 361 (1-2) ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Wuchao Wang ◽

Xiuzhu Zhang ◽

Lie Yang ◽

Dawei Liu ◽

Guodong Liu ◽

...

Keyword(s):

Map Kinase ◽

Peritoneal Macrophages ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Map Kinase Pathway ◽

Kinase Pathway

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