Determination of mTORC1 Complex Structures Reveals Regulatory Mechanisms

2018 ◽  
Vol 8 (2) ◽  
pp. OF11-OF11
ChemInform ◽  
2010 ◽  
Vol 24 (2) ◽  
pp. no-no
Author(s):  
R. E. MORRIS ◽  
W. T. A. HARRISON ◽  
J. M. NICOL ◽  
A. P. WILKINSON ◽  
A. K. CHEETHAM

2006 ◽  
Vol 324-325 ◽  
pp. 787-792
Author(s):  
Boris Aberšek ◽  
Jože Flašker ◽  
Srečko Glodež

For accurate determination of the service life we must take into account the loading, which are in most cases random loading of variable amplitude, the geometry and material properties of construction elements which are known not to be constants. The more precise these input parameters are modeled; the more precise and reliable are the results. In our paper we will deal in detail with the model of crack initiation and propagation in the complex structures as a basis of the algorithm for calculating the service life. For determination of the service life for the area of short cracks we used Bilby, Cottrell and Swinden model which is based on the theory of continuously distributed dislocations and we complemented it with random generation of structure of material before cracks. For the long crack we have developed a stochastic model for determination of service life.


1977 ◽  
Vol 55 (14) ◽  
pp. 1996-2000 ◽  
Author(s):  
M. O. Garraway ◽  
R. C. Evans

Sporulation of the fungus Bipolaris maydis increased and peroxidase (EC 1.11.1.7) activity decreased when xylose was added as a supplement to a basal glucose – mineral salts – agar medium containing either L-asparagine or NaNO3. With L-asparagine, thiamine–HCl (1.0 mg/ℓ) caused a significant decrease in sporulation and an increase in peroxidase activity. The magnitude of the decrease induced by thiamine–HCl in sporulation and increase in residue peroxidase activity appeared greater on a non-supplemented medium than on one supplemented with xylose. With NaNO3, the magnitude of the decrease in sporulation induced by 0.1 mg/ℓ thiamine–HCl appeared comparable whether or not the medium was supplemented with xylose, but the magnitude of the increase in residue peroxidase activity was greater without than with xylose. Quantitative determination of intracellular phenols as possible substrates for peroxidase revealed that there was no change in total phenol concentration regardless of the xylose and thiamine–HCl content of the media. The apparent inverse relationship between sporulation and peroxidase activity in B. maydis provides clues to the specific regulatory mechanisms involved in sporulation.


Author(s):  
Evelyne Tzoukermann ◽  
Judith L. Klavans ◽  
Tomek Strzalkowski

Information retrieval (IR) involves retrieving information from stored data, through user queries or pre-formulated user profiles. The information can be in any format. IR typically advances over four broad stages viz., identification of text types, document preprocessing, document indexing, and query processing and matching the same to documents. Although NLP has a role to play in IR, the procedural complexities of the latter impede determination of the stage of incorporation of the former into the latter. Earliest attempts at connecting NLP with IR, were extremely ambitious, proposing concepts instead of terms, as complex structures, to be compared using sophisticated algorithms. In its current state, IR still comes in handy, to retrieve information from various thesauri and ontologies, both in general-purpose lexical databases, as well as those categorizing knowledge in particular scientific and trade domains. However, NLP has yet to prove a better compatibility with IR, in enhancing the latter.


1994 ◽  
Vol 111 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Russell E. Morris ◽  
Jonathan J. Owen ◽  
Judith K. Stalick ◽  
Anthony K. Cheetham

Author(s):  
A. M. Hopgood

ABSTRACTIn spite of the structural complexity of polyphase deformed gneisses and migmatites and the absence of distinctive marker horizons, these rocks are amenable to structural investigation and interpretation with resolution of their tectonic history possible, particularly in regions of reasonable exposure. Although methods such as those employing interpretation of stereo-plots can seldom be used, direct observation of refold relationships on the outcrop using all available structural, igneous and metamorphic features will ultimately lead to the resolution of the deformational history. This is achieved by determining the relationships of fold sets observed at the various localities examined throughout the field of investigation and then combining these by correlation according to basic stratigraphical principles. The effects of weak deformation normally not discernible in complicated successions may be detected by the simple form of folded planar and linear structures in igneous masses emplaced in complex structures at intermediate stages in the deformational history.Synthesis of the total succession and determination of the overall sequence of deformation in particularly complex terranes is made easier if at least one distinctive set of structures can be recognised throughout the area. These key structures have the effect of subdividing the long succession into two in which refold relationships are generally more easily determined. An example of the method is given using photographs from the migmatite terrane in southern Finland.


Sign in / Sign up

Export Citation Format

Share Document