Role of Mesangial Cell Damage in Progressive Renal Disease

1999 ◽  
Vol 22 (1-2) ◽  
pp. 5-12 ◽  
Author(s):  
F. Shimizu ◽  
H. Kawachi ◽  
M. Orikasa
Keyword(s):  
Renal Disease ◽  
Mesangial Cell ◽  
Cell Damage ◽  
Progressive Renal Disease

Role of Tubular Cells in Progressive Renal Disease

1999 ◽  
Vol 22 (1-2) ◽  
pp. 53-61 ◽  
Author(s):  
Cees van Kooten ◽  
Alexandra M.J. Langers ◽  
Jan A. Bruijn ◽  
Mohamed R. Daha
Keyword(s):  
Renal Disease ◽  
Tubular Cells ◽  
Progressive Renal Disease

scholarly journals Perilla frutescens Sprout Extract Protect Renal Mesangial Cell Dysfunction against High Glucose by Modulating AMPK and NADPH Oxidase Signaling

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 356 ◽  
Author(s):  
Ha-Rim Kim ◽  
Seon-Young Kim
Keyword(s):  
High Glucose ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Cell Damage ◽  
Perilla Frutescens ◽  
Activation Mechanism ◽  
Glomerular Mesangial Cells ◽  
Ampk Activation ◽  
Cell Dysfunction

Perilla frutescens (L.) Britt. var. japonica (Hassk.) Hara (PF), is a medical herb of the Lamiaceae family. We have previously reported that the PF sprout extract (PFSE) is effective in treating hyperglycemia. However, the role of PFSE on glomerular mesangial cells (MCs) proliferation and the extracellular matrix (ECM) accumulation in a diabetic condition are still unclear. Therefore, in this study, we have investigated the role of PFSE on cell proliferation and ECM accumulation in murine glomerular MCs (MMCs), cultured under a high glucose (HG) condition. PFSE treatment attenuated HG-induced MMCs proliferation and hypertrophy. Moreover, the HG-induced ECM protein, collagen IV and fibronectin, overexpression was abolished by the PFFSE treatment. In addition, PFSE inhibited reactive oxygen species (ROS) overproduction and NOX2 and NOX4 expression in MMCs under a HG condition. Our data further revealed the involvement of mesangial cell damage in AMP-activated kinase (AMPK) activation. PFSE strongly activated AMPK in MMCs under hyperglycemic conditions. These results suggest that PFSE inhibits HG-medicated MC fibrosis through suppressing the activation of NOX2/4 and the AMPK activation mechanism. PFSE may be useful for the prevention or treatment of diabetic nephropathy.

Hypertension

2021 ◽  
pp. 43-61
Keyword(s):  
Renal Disease ◽  
Renal Artery ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Western World ◽  
Interventional Treatment ◽  
Lifestyle Modifications ◽  
Artery Disease ◽  
Progressive Renal Disease

Hypertension (HTN) is a common condition and a risk factor for numerous comorbidities, including cardiovascular disease, cerebrovascular disease, and progressive renal disease. In many people the aetiology of HTN is unknown, but in some a triggering “secondary” cause can be identified, e.g. renal disease, endocrine, or other underlying condition. For most people the treatment of HTN is straightforward, but in a small number the blood pressure can become “malignant or accelerated” and require urgent treatment or hospitalization. The chapters in this section provide an overview of the clinical assessment and investigation of a hypertensive patient, the recommended lifestyle modifications and pharmacological treatment options available, and potential complications of HTN. Renal artery stenosis a common cause of HTN that can be caused by atheromatous renovascular disease (ARVD) or other rarer pathologies, including fibromuscular disease, Takayasu’s arteritis, or other syndromes. ARVD is the commonest cause of renal artery disease in the Western world and in this section the authors focus upon the epidemiology and clinical presentation of ARVD and the potential diagnostic and treatment strategies. A particular focus is given to the role of medical and interventional treatment of ARVD, including potential outcomes, complications, and prognosis.

scholarly journals Gonadal steroid regulation of renal injury in renal wrap hypertension

2005 ◽  
Vol 288 (3) ◽  
pp. F513-F520 ◽  
Author(s):  
Hong Ji ◽  
Stefano Menini ◽  
Koby Mok ◽  
Wei Zheng ◽  
Carlo Pesce ◽  
...  
Keyword(s):  
Renal Disease ◽  
Renal Injury ◽  
Gonadal Steroids ◽  
Female Rats ◽  
Tubular Damage ◽  
Gonadal Steroid ◽  
Ovx Rats ◽  
17Β Estradiol ◽  
Progressive Renal Disease

Renal injury is greater in male compared with female rats after renal wrap (RW) hypertension. We investigated the role of gonadal steroids in the sex differences in RW disease severity in male (M) and female (F), castrated (Cast), and ovariectomized (OVX) rats and after dihydrotestosterone (DHT) and 17β-estradiol (E2) treatment. Male castration attenuated the severity of RW-induced glomerulosclerosis (GS) [GS index (GSI): RW-M, 2.1 ± 0.2; RW-Cast, 1.3 ± 0.2; RW-Cast+DHT, 2.4 ± 0.4], mean glomerular volume (MGV; μm3 × 106: RW-M, 1.9 ± 0.1; RW-Cast, 1.45 ± 0.15; RW-Cast+DHT, 1.91 ± 0.15), tubular damage, and proteinuria (mg/day: RW-M, 130 ± 8; RW-Cast, 105 ± 5; RW-Cast+DHT, 142 ± 9), whereas DHT treatment abrogated these effects. Ovariectomy increased the GSI (RW-F, 0.69 ± 0.05; RW-OVX, 1.2 ± 0.1; RW-OVX+E2, 0.65 ± 0.05), tubular damage, and MGV (μm3 × 106: RW-F, 1.0 ± 0.06; RW-OVX, 1.5 ± 0.05; RW-OVX+E2, 0.96 ± 0.06), whereas E2 treatment prevented these effects. Furthermore, DHT treatment of RW-OVX animals exacerbated the GSI (1.9 ± 0.19), MGV (1.7 ± 0.2 × 106 μm3), and proteinuria (171 ± 21 mg/day) even further. Our data show that the lack of E2 and presence of androgens contribute to progressive renal disease induced by RW hypertension, suggesting that gonadal steroid status is an independent factor in the greater susceptibility men exhibit toward hypertension-associated renal disease compared with women.

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