Temporal Relationship between the Auditory Brainstem Response and Focal Responses of Auditory Nerve Root and Cochlear Nucleus during Development in the Tammar Wallaby (Macropus eugenii)

2001 ◽  
Vol 6 (3) ◽  
pp. 140-153 ◽  
Author(s):  
Guang B. Liu ◽  
Kenneth G. Hill ◽  
Richard F. Mark
Keyword(s):  
Cochlear Nucleus ◽  
Auditory Nerve ◽  
Nerve Root ◽  
Auditory Brainstem Response ◽  
Temporal Relationship ◽  
Tammar Wallaby ◽  
Auditory Brainstem ◽  
Macropus Eugenii ◽  
Brainstem Response

Auditory brainstem response in tammar wallaby (Macropus eugenii)

1997 ◽  
Vol 105 (1-2) ◽  
pp. 119-129 ◽  
Author(s):  
Barbara K. Cone-Wesson ◽  
Kenneth G. Hill ◽  
Guang-Bin Liu
Keyword(s):  
Auditory Brainstem Response ◽  
Tammar Wallaby ◽  
Auditory Brainstem ◽  
Macropus Eugenii ◽  
Brainstem Response

Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus

2011 ◽  
Vol 114 (2) ◽  
pp. 414-425 ◽  
Author(s):  
Tetsuji Sekiya ◽  
Masahiro Matsumoto ◽  
Ken Kojima ◽  
Kazuya Ono ◽  
Yayoi S. Kikkawa ◽  
...  
Keyword(s):  
Mechanical Stress ◽  
Cochlear Nucleus ◽  
Auditory Nerve ◽  
Auditory Brainstem ◽  
Reactive Gliosis ◽  
Auditory Pathways ◽  
Microsurgical Treatment ◽  
Auditory Nerves ◽  
Brainstem Response ◽  
Temporal Bones

Object Hearing levels following microsurgical treatment gradually deteriorate in a number of patients treated for vestibular schwannoma (VS), especially in the subacute postoperative stage. The cause of this late-onset deterioration of hearing is not completely understood. The aim of this study was to investigate the possibility that reactive gliosis is a contributory factor. Methods Mechanical damage to nerve tissue is a feature of complex surgical procedures. To explore this aspect of VS treatment, the authors compressed rat auditory nerves with 2 different degrees of injury while monitoring the compound action potentials of the auditory nerve and the auditory brainstem responses. In this experimental model, the axons of the auditory nerve were quantitatively and highly selectively damaged in the cerebellopontine angle without permanent compromise of the blood supply to the cochlea. The temporal bones were processed for immunohistochemical analysis at 1 week and at 8 weeks after compression. Results Reactive gliosis was induced not only in the auditory nerve but also in the cochlear nucleus following mechanical trauma in which the general shape of the auditory brainstem response was maintained. There was a substantial outgrowth of astrocytic processes from the transitional zone into the peripheral portion of the auditory nerve, leading to an invasion of dense gliotic tissue in the auditory nerve. The elongated astrocytic processes ran in parallel with the residual auditory neurons and entered much further into the cochlea. Confocal images disclosed fragments of neurons scattered in the gliotic tissue. In the cochlear nucleus, hypertrophic astrocytic processes were abundant around the soma of the neurons. The transverse diameter of the auditory nerve at and proximal to the compression site was considerably reduced, indicating atrophy, especially in rats in which the auditory nerve was profoundly compressed. Conclusions The authors found for the first time that mechanical stress to the auditory nerve causes substantial reactive gliosis in both the peripheral and central auditory pathways within 1–8 weeks. Progressive reactive gliosis following surgical stress may cause dysfunction in the auditory pathways and may be a primary cause of progressive hearing loss following microsurgical treatment for VS.

Diffusion Tensor Imaging of Auditory Pathway in Patients With Crigler-Najjar Syndrome Type I: Correlation With Auditory Brainstem Response

2021 ◽  
pp. 088307382110258
Author(s):  
Ahmed Abdel Khalek Abdel Razek ◽  
Mohamed Ezz El Regal ◽  
Mortada El-Shabrawi ◽  
Mohamed Moustafa Abdeltawwab ◽  
Ahmed Megahed ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Inferior Colliculus ◽  
Cochlear Nucleus ◽  
Auditory Brainstem Response ◽  
Diffusion Tensor ◽  
Auditory Brainstem ◽  
Type I ◽  
Syndrome Type ◽  
Brainstem Response ◽  
Olivary Nucleus

Aim: To evaluate the role of diffusion tensor imaging of the auditory pathway in patients with Crigler Najjar syndrome type I and its relation to auditory brainstem response. Methods: Prospective study was done including 12 patients with Crigler Najjar syndrome type I and 10 age- and sex-matched controls that underwent diffusion tensor imaging of brain. Mean diffusivity and fractional anisotropy at 4 regions of the brain and brainstem on each side were measured and correlated with the results of auditory brainstem response for patients. Results: There was significantly higher mean diffusivity of cochlear nucleus, superior olivary nucleus, inferior colliculus, and auditory cortex of patients versus controls on both sides for all regions ( P = .001). The fractional anisotropy of cochlear nucleus, superior olivary nucleus, inferior colliculus, and auditory cortex of patients versus controls was significantly lower, with P values of, respectively, .001, .001, .003, and .001 on the right side and .001, .001, .003, and .001 on left side, respectively. Also, a negative correlation was found between the maximum bilirubin level and fractional anisotropy of the left superior olivary nucleus and inferior colliculus of both sides. A positive correlation was found between the mean diffusivity and auditory brainstem response wave latency of the right inferior colliculus and left cochlear nucleus. The fractional anisotropy and auditory brainstem response wave latency of the right superior olivary nucleus, left cochlear nucleus, and inferior colliculus of both sides were negatively correlated. Conclusion: Diffusion tensor imaging can detect microstructural changes in the auditory pathway in Crigler Najjar syndrome type I that can be correlated with auditory brainstem response.

scholarly journals Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Melissa J Polonenko ◽  
Ross K Maddox
Keyword(s):  
Speech Processing ◽  
Auditory Nerve ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Clinical Applications ◽  
Subcortical Structures ◽  
Deconvolution Analysis ◽  
Speech Encoding ◽  
Brainstem Response ◽  
Eeg Recordings

Speech processing is built upon encoding by the auditory nerve and brainstem, yet we know very little about how these processes unfold in specific subcortical structures. These structures are deep and respond quickly, making them difficult to study during ongoing speech. Recent techniques begin to address this problem, but yield temporally broad responses with consequently ambiguous neural origins. Here we describe a method that pairs re-synthesized 'peaky' speech with deconvolution analysis of EEG recordings. We show that in adults with normal hearing, the method quickly yields robust responses whose component waves reflect activity from distinct subcortical structures spanning auditory nerve to rostral brainstem. We further demonstrate the versatility of peaky speech by simultaneously measuring bilateral and ear-specific responses across different frequency bands, and discuss important practical considerations such as talker choice. The peaky speech method holds promise as a tool for investigating speech encoding and processing, and for clinical applications.

Brainstem pathology of infantile Gaucher's disease with only wave I and II of auditory brainstem response

1998 ◽  
Vol 112 (11) ◽  
pp. 1069-1073 ◽  
Author(s):  
Kimitaka Kaga ◽  
Masae Ono ◽  
Kazuhiro Yakumaru ◽  
Masao Owada ◽  
Toshlo Mizutani
Keyword(s):  
Cochlear Nucleus ◽  
Auditory Brainstem Response ◽  
Failure To Thrive ◽  
Auditory Brainstem ◽  
Pathological Findings ◽  
Gaucher's Disease ◽  
Gaucher’S Disease ◽  
Brainstem Response ◽  
Ventral Nucleus ◽  
Olivary Nucleus

AbstractWe studied the auditory brainstem response (ABR) and neuropathology in a female infant who died at six months of age because of typical infantile Gaucher's disease. The patient was hospitalized for hepatosplenomegaly and failure to thrive. Her ABR showed only waves I and II.The neuropathological study disclosed that: (1) Gaucher's cells were found in the perivascular region of the cerebrum and anterior ventral nucleus of the thalamus. (2) Gliosis was found in the dorsal part of the brainstem rather than the ventral part. (3) Neuronal cells in the superior olivary nucleus were lost, and marked gliosis was found in the cochlear nucleus. The disappearance of wave III and later waves of ABR could be supported by these pathological findings.

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