Tegaserod: Long-Term Treatment for Irritable Bowel Syndrome Patients with Constipation in Primary Care

Digestion ◽  
2005 ◽  
Vol 71 (4) ◽  
pp. 238-244 ◽  
Author(s):  
Peter Layer ◽  
Jutta Keller ◽  
Stefan Mueller-Lissner ◽  
Peter Rüegg ◽  
Helena Loeffler
2013 ◽  
Vol 48 (10) ◽  
pp. 1127-1135 ◽  
Author(s):  
Luise Mølenberg Begtrup ◽  
Ove B Schaffalitzky de Muckadell ◽  
Jens Kjeldsen ◽  
René dePont Christensen ◽  
Dorte Ejg Jarbøl

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Stefano Evangelista

It is known that irritable bowel syndrome (IBS) is a chronic disease of cyclic nature characterized by recurrent symptoms. IBS patients should receive, as initial therapeutic approach a short course of treatment which, if effective, has the additional value of confirming the diagnosis. Long-term treatment should be reserved to diagnosed IBS patients with recurrent symptoms. Clinical trials with stabilized therapies and new active treatments showed an improvement of the symptoms over placebo that is often time-dependent but with high relapse rates (around 40%–50% when stopping treatment). Relapse is not always immediate after stopping treatment and the recent data from OBIS trial with otilonium bromide or with psychotherapy, showed that due to different chemico-physical characteristics of the drugs or the psychosomatic impact to the disease not all treatment gave the same relapsing rate if compared to placebo. Results of IBS clinical trials with different therapies tailored to the patient needs indicate that a cyclic treatment therapy is advisable to counteract the nature of the disease.


2001 ◽  
Vol 21 (1) ◽  
pp. 53
Author(s):  
J Hauptman ◽  
C Lucas ◽  
M N Boldrin ◽  
H Collins ◽  
K R Segal

2000 ◽  
Vol 15 (12) ◽  
pp. 868-877 ◽  
Author(s):  
Lisa S. Meredith ◽  
Maga Jackson-Triche ◽  
Naihua Duan ◽  
Lisa V. Rubenstein ◽  
Patti Camp ◽  
...  

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