Orlistat in the Long-term Treatment of Obesity in Primary Care Settings.

The effectiveness and tolerance of a non-amphetaminic anorexiant drug has been evaluated in a short-term and in a long-term clinical trial in simple obesity and in refractory obesity. In the short-term ‘crossover’ trial, a more evident effectiveness and tolerance result when the anorexiant is given in a late phase of treatment. The association of an anorexiant drug with the hypocaloric diet was seen to be effective in the treatment of so-called refractory obesity. In the evaluation of the long-term treatment it is seen that weight loss is greater and remains so for longer periods in patients receiving anorexiant, as compared to controls. This is related to a better maintenance of a restricted calorie regimen. Mazindol did not affect the improvement of glucose tolerance and insulin secretion which follows the weight reduction.

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Long-term treatment with antidepressants in primary care

Psychiatric Bulletin ◽

10.1192/pb.22.1.15 ◽

1998 ◽

Vol 22 (1) ◽

pp. 15-19 ◽

Cited By ~ 19

Author(s):

Imad M. Ali

Keyword(s):

Primary Care ◽

General Practice ◽

Depressive Symptoms ◽

General Practitioner ◽

Term Treatment ◽

Postal Survey ◽

Consultation Rate ◽

Long Term Treatment ◽

Higher Doses

A postal survey of 222 patients receiving long-term antidepressants in a training general practice showed that the majority were GHQ-12 cases and 62% of respondents reported moderate or severe depressive symptoms on the BDI-13. Although these patients received significantly higher doses than those reporting few or no symptoms, only 40% were prescribed at least a therapeutic antidepressant dose. All patients reporting mild, moderate or severe depressive symptoms consulted their general practitioner significantly more frequently than those without symptoms and the content of these consultations suggested that the general practitioners were aware of these patients' psychological morbidity. Monitoring and appropriate management of patients receiving long-term antidepressants could lead to reduction in morbidity and consultation rate.

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Observations on obese patients eating isocaloric reducing diets with varying proportions of carbohydrate

British Journal Of Nutrition ◽

10.1079/bjn19700008 ◽

1970 ◽

Vol 24 (1) ◽

pp. 39-44 ◽

Cited By ~ 11

Author(s):

Cathryn E. A. Hood ◽

J. M. Goodhart ◽

R. F. Fletcher ◽

Josephine Gloster ◽

P. V. Bertrand ◽

...

Keyword(s):

Weight Loss ◽

Term Treatment ◽

Obese Patients ◽

Long Term Treatment ◽

Significant Difference ◽

Simple Obesity ◽

Treatment Of Obesity ◽

Sparing Effect

1. Diets containing 1000 kcal/day with varying proportions of carbohydrate (CHO) were fed to four women with simple obesity. The patients were given, in various sequences and for 8 days in each instance, diets in which 3, 6, 12, 25 or 50% of the calories were supplied by sucrose.2. No significant difference in the rate of weight loss was found when the diets of graded CHO content were fed and mean weight loss was 1.2 kg/week.3. The high-CHO diets were antiketogenic; there was no daily relationship between urinary ketones and sodium. The 25 and 50% CHO diets had a nitrogen-sparing effect.4. A 1000 kcal/day diet with about a third of the calories derived from CHO leads to a useful rate of weight loss and minimum changes in body chemistry. This finding may have implications in the long-term treatment of obesity.

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