Lack of Local Anesthetic Properties of Lidocaine Gel in an Experimental Model

2006 ◽  
Vol 76 (4) ◽  
pp. 359-363 ◽  
Author(s):  
T. Drewa ◽  
Z. Wolski ◽  
P. Galazka ◽  
D. Olszewska-Slonina ◽  
D. Musialkiewicz ◽  
...  
2017 ◽  
Vol 34 (3) ◽  
pp. 143-149 ◽  
Author(s):  
Ryan M. Diepenbrock ◽  
Jason R. May ◽  
William Randall Cone ◽  
Elise L. Ehland

This study was designed to compare 2 common techniques for anesthesia prior to facial filler injections to determine which anesthetic method resulted in less pain during filler injections and which was preferred for future treatments. Via a randomized, prospective, split-face design, one side was treated with topical lidocaine gel and the contralateral received nerve block injection(s) to the infraorbital and/or mental nerve with local anesthetic. Hyaluronic acid (HA) filler was used to treat cosmetic deformities of the nasolabial folds, upper, and/or lower lips. Patients were surveyed to quantify the subjective pain during (1) preprocedural anesthesia and (2) injection of HA filler. At 1 week, patients reported which side was perceived as less painful, and his or her future treatment preference. Forty-eight participants (46 women and 2 men) were enrolled. In all, 77% perceived the filler injections with anesthetic block(s) as less painful, 21% recorded injections on the side pretreated with topical anesthesia as less painful, and 2% perceived no difference. Of all participants, 56% preferred local anesthetic injections for future treatments, 33% chose topical anesthesia, and 10% (5 of 48) had no preference. Patients rated the treatment of HA injections after anesthetic block(s) as the least painful method. Although more than half of the patients preferred this modality, the posttreatment survey suggests that there may be other factors contributing to patients’ preferences.


2018 ◽  
Vol 8 (3) ◽  
pp. 157-160
Author(s):  
Arif Ozkan ◽  
◽  
Nusret Can Cilesiz ◽  
Arif Kalkanli ◽  
Kadir Omur Gunseren ◽  
...  

Author(s):  
Waykin Nopanitaya ◽  
Raeford E. Brown ◽  
Joe W. Grisham ◽  
Johnny L. Carson

Mammalian endothelial cells lining hepatic sinusoids have been found to be widely fenestrated. Previous SEM studies (1,2) have noted two general size catagories of fenestrations; large fenestrae were distributed randomly while the small type occurred in groups. These investigations also reported that large fenestrae were more numerous and larger in the endothelial cells at the afferent ends of sinusoids or around the portal areas, whereas small fenestrae were more numerous around the centrilobular portion of the hepatic lobule. It has been further suggested that under some physiologic conditions small fenestrae could fuse and subsequently become the large type, but this is, as yet, unproven.We have used a reproducible experimental model of hypoxia to study the ultrastructural alterations in sinusoidal endothelial fenestrations in order to investigate the origin of occurrence of large fenestrae.


2003 ◽  
Vol 2 (1) ◽  
pp. 33-34
Author(s):  
B SHIVALKAR ◽  
B MEURIS ◽  
R VANBENEDEN ◽  
J KETESLEGERS ◽  
F BECKERS ◽  
...  

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
IST Figueiredo ◽  
FT Benevides ◽  
NMS Queiroz ◽  
LM Marques ◽  
TFG Souza ◽  
...  

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