Anti-inflammatory effect of Uncaria tomentosa in an experimental model of cyclophosphamide-induced hemorrhagic cystitis

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
IST Figueiredo ◽  
FT Benevides ◽  
NMS Queiroz ◽  
LM Marques ◽  
TFG Souza ◽  
...  
Keyword(s):  
Experimental Model ◽  
Hemorrhagic Cystitis ◽  
Uncaria Tomentosa ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Therapeutic Effects of Sodium Hyaluronate and Diclofenac Sodium in Chronic Arthritis

2019 ◽  
Vol 7 (4) ◽  
pp. 17-33
Author(s):  
Alsadek H Bogzil ◽  
Gamal Shams ◽  
Sohair Abd El-Latif
Keyword(s):  
Experimental Model ◽  
Diclofenac Sodium ◽  
Sodium Hyaluronate ◽  
Chronic Arthritis ◽  
Albino Rats ◽  
Therapeutic Effects ◽  
Monosodium Iodoacetate ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The present study was designed to compare the anti-inflammatory effect of sodium hyaluronate, which is similar to the lubricant fluid that found naturally in the capsule of the healthy joint with diclofenac sodium, a member of NSAIDs commonly used in treatment of Osteoarthritis (OA), separately and in combination on an experimental model of osteoarthritis in rats induced by monosodium-iodoacetate (MIA). Twenty-five male albino rats weighing at the beginning of the experiment 160± 20 gm were used in this study. Rats were housed in cages at 25± 0.5°C. The rats were divided into 5 main groups.  

scholarly journals Inhibitory effects of Spirulina in zymosan-induced arthritis in mice

2002 ◽  
Vol 11 (2) ◽  
pp. 75-79 ◽  
Author(s):  
Diadelis Remirez ◽  
Ricardo González ◽  
Nelson Merino ◽  
Sandra Rodriguez ◽  
Odelsa Ancheta
Keyword(s):  
Endoplasmic Reticulum ◽  
Synovial Fluid ◽  
Knee Joint ◽  
Experimental Model ◽  
Inflammatory Reaction ◽  
Inhibitory Effects ◽  
Ultrastructural Studies ◽  
Anti Inflammatory ◽  
Histopathological Studies ◽  
Inflammatory Effect

The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, whereas no destruction of cartilage, well-preserved chondrocytes, and normal rough endoplasmic reticulum and mitochondria were seen. The anti-arthritic effect exerted by Spirulina as shown in this model may be at least partly due to the previously reported anti-inflammatory and antioxidative properties of its constituent, phycocyanin. To our knowledge, this is the first report on the anti-inflammatory effect of Spirulina in an experimental model of arthritis.

scholarly journals PPARαmediates the anti-inflammatory effect of simvastatin in an experimental model of zymosan-induced multiple organ failure

2011 ◽  
Vol 163 (3) ◽  
pp. 609-623 ◽  
Author(s):  
Barbara Rinaldi ◽  
Maria Donniacuo ◽  
Emanuela Esposito ◽  
Annalisa Capuano ◽  
Loredana Sodano ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Experimental Model ◽  
Multiple Organ ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis

Inflammation ◽  
2020 ◽  
Vol 43 (3) ◽  
pp. 985-993 ◽  
Author(s):  
Ana Paula Santos Tartari ◽  
Felipe Figueiredo Moreira ◽  
Mário César Da Silva Pereira ◽  
Emerson Carraro ◽  
Francisco José Cidral-Filho ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Experimental Model ◽  
Ozone Therapy ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-Inflammatory Effect of the Latex fromCalotropis procerain Three Different Experimental Models: Peritonitis, Paw Edema and Hemorrhagic Cystitis

Planta Medica ◽  
2004 ◽  
Vol 70 (12) ◽  
pp. 1144-1149 ◽  
Author(s):  
N. M. Alencar ◽  
I. S. Figueiredo ◽  
M. R. Vale ◽  
F. S. Bitencurt ◽  
J. S. Oliveira ◽  
...  
Keyword(s):  
Hemorrhagic Cystitis ◽  
Experimental Models ◽  
Paw Edema ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Synthesis of cyclohexylaliphatic acids and their pharmacological properties

1986 ◽  
Vol 51 (12) ◽  
pp. 2896-2908 ◽  
Author(s):  
Miroslav Kuchař ◽  
Bohumila Brunová ◽  
Jaroslava Grimová ◽  
Stanislav Vaněček ◽  
Jiří Holubek
Keyword(s):  
Double Bond ◽  
Experimental Model ◽  
Active Site ◽  
Wittig Reaction ◽  
Qualitative Assessment ◽  
Pharmacological Properties ◽  
Phenyl Derivative ◽  
Anti Inflammatory ◽  
Fibrinolytic Capacity ◽  
Inflammatory Effect

A series of substituted cyclohexylacetic acids I has been obtained by hydrogenation of the unsaturated analogues II and III. Esters of these analogues were prepared by the Horner-Wittig reaction of the corresponding cyclohexanones IV and/or 2-cyclohexenones V with triethyl phosphonoacetate. These esters were obtained in two isomeric forms (Z and E), differing in the double bond in the exo-position. The derivatives with a substituent in the 2-position exhibited a partial shift of the double bond to the cyclohexane ring; this shift was especially marked in the 2-phenyl derivative. With the acids I-III, activation of fibrinolysis was assessed by the hanging clot method; the anti-inflammatory effect was assessed by inhibition of two experimental model inflammations. The regression equation relating fibrinolytic capacity to lipophilicity was a quadratic one, the logarithm of optimum lipophilicity being log Popt = 5.55. A qualitative assessment of the anti-inflammatory effect in relation to lipophilicity suggests that log Popt is probably higher than with arylaliphatic acids. These acids seem to have an active site different from that of the acids I-III.

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