Hindbrain Neuroglucopenia Elicits Site-Specific Transcriptional Activation of Glutamate Decarboxylase-Immunopositive Neurons in the Septopreoptic Area of Female Rat Brain

2008 ◽  
Vol 87 (2) ◽  
pp. 113-120 ◽  
Author(s):  
Karen P. Briski ◽  
Sushma R. Singh
Keyword(s):  
Rat Brain ◽  
Transcriptional Activation ◽  
Glutamate Decarboxylase ◽  
Female Rat ◽  
Site Specific

Maternal Exposure to Δ 9 -Tetrahydrocannabinol ( Δ 9 -THC) Alters Indolamine Levels and Turnover in Adult Male and Female Rat Brain Regions

1997 ◽  
Vol 43 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Francisco Molina-Holgado ◽  
Francisco J. Alvarez ◽  
Isabel Gonzalez ◽  
Maria T. Antonio ◽  
Maria L. Leret
Keyword(s):  
Rat Brain ◽  
Adult Male ◽  
Brain Regions ◽  
Maternal Exposure ◽  
Female Rat ◽  
Male And Female ◽  
Rat Brain Regions

EFFECTS OF OESTRADIOL-17β, OESTRADIOL BENZOATE AND THE SYNTHETIC OESTROGEN RU 2858 ON SEXUAL DIFFERENTIATION IN THE NEONATAL FEMALE RAT

1975 ◽  
Vol 67 (3) ◽  
pp. 419-424 ◽  
Author(s):  
CYNTHIA DOUGHTY ◽  
JANET E. BOOTH ◽  
P. G. McDONALD ◽  
R. F. PARROTT
Keyword(s):  
Rat Brain ◽  
Sexual Differentiation ◽  
Neonatal Rat ◽  
Female Rats ◽  
Sexual Receptivity ◽  
Female Rat ◽  
Neonatal Rats ◽  
Oestradiol Benzoate ◽  
Ovarian Cyclicity ◽  
Neonatal Rat Brain

SUMMARY Groups of neonatal female rats were treated for the first 5 days of life with oestradiol-17β, oestradiol benzoate or a synthetic oestrogen, 11β-methoxy-17-ethynyl-1,3,5(10)-oestratriene-3,17β-diol (RU 2858), in daily doses ranging from 0·5 to 1000 ng. Oestradiol-17β had no effect on adult ovarian cyclicity or sexual receptivity after ovariectomy and oestrogen + progesterone treatment. Ovarian cyclicity was prevented by 100 ng or more oestradiol benzoate/day, and by all doses of RU 2858. Only rats receiving 50 ng oestradiol benzoate/ day or 0·5 ng RU 2858/day showed normal receptivity. The defeminizing action of RU 2858 was at least 100 times greater than that of oestradiol benzoate; it is suggested that this greater potency is due to the low affinity of RU 2858 for the oestradiol-binding protein in the plasma of neonatal rats. These results indicate that defeminization of the neonatal rat brain can be induced by physiological amounts of oestrogen, and are discussed with reference to the action of testosterone.

Age-related changes in the soluble and the membrane-bound Tyr-aminopeptidase activities in several areas of the male and female rat brain

1996 ◽  
Vol 8 (3) ◽  
pp. 465 ◽  
Author(s):  
Gandarias JM de ◽  
J Irazusta ◽  
E Echevarria ◽  
J Gil ◽  
L Casis
Keyword(s):  
Rat Brain ◽  
Peptidase Activity ◽  
Female Rat ◽  
Major Pathway ◽  
Male And Female ◽  
Aminopeptidase M ◽  
Age Related ◽  
Female Brain ◽  
Membrane Bound ◽  
Cellular Development

It has been recently suggested that enkephalins might play a normal role in the regulation of cellular development in brain. Since the major pathway of enkephalin degradation seems to occur under the action of aminopeptidases, in the present paper we describe the changes in Tyr-aminopeptidase activities during several stages of the rat (male and female) brain development (9, 12, 15, 20 and 25 days postbirth). The enzyme activities (soluble and membrane-bound) were detected using Tyr-2-naphthylamide as substrate. No sexual differences were observed. However, significant rises from the 9th to the 15th postnatal day in the soluble peptidase activity were appreciated. Aminopeptidase M shows decreases in the activity with age. It is suggested that not only the enkephalins but also the enkephalin-degrading enzymes could play a part in the maturation of the rat brain.

Sign in / Sign up

Export Citation Format

Share Document