Quantitative Histological Changes in the Rat Hypothalamus Following Bilateral Adrenalectomy

1972 ◽  
Vol 10 (1) ◽  
pp. 23-30 ◽  
Author(s):  
M. Palkovits ◽  
E. Stark
Keyword(s):  
Bilateral Adrenalectomy ◽  
Histological Changes ◽  
Rat Hypothalamus

EFFECT OF BILATERAL ADRENALECTOMY AND CORTICOSTEROID THERAPY ON THE SECRETION OF CORTICOTROPHIN-RELEASING FACTOR ACTIVITY FROM THE HYPOTHALAMUS OF THE RAT IN VITRO

1976 ◽  
Vol 71 (1) ◽  
pp. 21-30 ◽  
Author(s):  
E. W. HILLHOUSE ◽  
M. T. JONES
Keyword(s):  
Replacement Therapy ◽  
Corticosteroid Therapy ◽  
Negative Feedback ◽  
Control Level ◽  
Bilateral Adrenalectomy ◽  
Factor Activity ◽  
Intact Control ◽  
Rat Hypothalamus ◽  
Corticotrophin Releasing Factor

SUMMARY The rat hypothalamus in vitro preparation was used to investigate the effect of bilateral adrenalectomy, with and without replacement therapy, on the release of corticotrophin-releasing factor (CRF). Corticotrophin-releasing factor was estimated using 48 h basal hypothalamic lesioned assay rats and corticosterone production of excised adrenals was used as the end point. Bilateral adrenalectomy resulted in depletion of hypothalamic CRF content within the first 2 h after the operation but this effect was prevented by replacement therapy with corticosterone. Thereafter, the hypothalamic CRF content returned to values not significantly different from the intact control level. Bilateral adrenalectomy caused an increase in both basal and acetylcholine-induced release of CRF and it is suggested that corticosteroids exert a negative feedback effect on the hypothalamus.

Chronic Laser Exposure Effects on Rabbit Retina

1972 ◽  
Vol 30 ◽  
pp. 54-55
Author(s):  
Burton B. Silver ◽  
Theodore Lawwill
Keyword(s):  
Laser Irradiation ◽  
Laser Light ◽  
Broad Band ◽  
Argon Laser ◽  
Atropine Sulfate ◽  
Ultrastructural Changes ◽  
Laser Exposure ◽  
Rabbit Retina ◽  
Histological Changes ◽  
Threshold Doses

Dutch-belted 1 to 2.5 kg anesthetized rabbits were exposed to either xenon or argon laser light administered in a broad band, designed to cover large areas of the retina. For laser exposure, the pupil was dilated with atropine sulfate 1% and pheny lephrine 10%. All of the laser generated power was within a band centered at 5145.0 Anstroms. Established threshold for 4 hour exposures to laser irradiation are in the order of 25-35 microwatts/cm2. Animals examined for ultrastructural changes received 4 hour threshold doses. These animals exhibited ERG, opthalmascopic, and histological changes consistent with threshold damage.One month following exposure the rabbits were killed with pentobarbitol. The eyes were immediately enucleated and dissected while bathed in 3% phosphate buffered gluteraldehyde.

Early histological changes in the aortic media after thoracic endovascular stent grafting (TEVAR)

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
J Scheumann ◽  
MS Bischoff ◽  
C Heilmann ◽  
M Siepe ◽  
F Roder ◽  
...  
Keyword(s):  
Endovascular Stent ◽  
Histological Changes ◽  
Stent Grafting ◽  
Endovascular Stent Grafting ◽  
Aortic Media

A Computerized Coding System for Processing Basic Histopathological Changes – Application to Vascular Pathology

1986 ◽  
Vol 25 (03) ◽  
pp. 139-142 ◽  
Author(s):  
A. Mauriello ◽  
Y. Sambuy ◽  
E. Bonanno ◽  
A. Orlandi ◽  
G. Palmieri ◽  
...  
Keyword(s):  
Vascular Wall ◽  
Final Diagnosis ◽  
Vascular Pathology ◽  
Histopathological Study ◽  
Coding System ◽  
Histopathological Changes ◽  
Histological Changes ◽  
Pathological Conditions ◽  
Computer Based ◽  
Sufficient Space

SummaryAmong the numerous existing computer-based systems for processing pathological data, none contains sufficient space for encoding data on the basic cytological or histological changes of a certain organ or tissue, upon which the final diagnosis is based.An “analytical record” was constructed listing all the basic changes that can be encountered in the various pathological conditions of the vascular wall. The data collected on the “analytical record” were coded by means of an alphanumeric code and stored in an Apple II 48 K minicomputer.The advantages of this system include the computerization of the data by non-specialized personnel and the possibility to’ quantitatively analyze the histocytopathological parameters used for diagnosis in vascular pathology. This coding system may easily be adapted, with minor modifications, to the histopathological study of other organs and tissues.

THIOURACIL TREATMENT IN PREGNANCY AND LACTATION IN THE DOG

1962 ◽  
Vol 40 (3) ◽  
pp. 430-440 ◽  
Author(s):  
K. E. Arosenius ◽  
H. Derblom ◽  
G. Nylander
Keyword(s):  
Thyroid Gland ◽  
List Type ◽  
Histological Changes ◽  
Morphological Effect ◽  
Iodine Metabolism ◽  
Pregnancy And Lactation ◽  
In Pregnancy

ABSTRACT The offspring of bitches treated with thiouracil during pregnancy and lactation were studied with regard to certain aspects of iodine metabolism and also to the morphological effect on the thyroid gland, as compared with controls of the same age and weight. At the age of six months, when the dogs were virtually fully grown, the thyroid gland still exhibited the effects of the thiouracil treatment of the mothers as manifested by an increased uptake of 131I, enlargement, and histological changes of a hyperplastic type. The significance of these deviations from normal iodine metabolism and morphology is discussed with particular reference to the dangers of thiouracil medication during pregnancy.

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