Postnatal Development of the Interstitial Cells (Palisade Cells) of the Pars Intermedia in the Cat Pituitary Gland. An Immunocytochemical and Ultrastructural Study

1991 ◽  
Vol 141 (3) ◽  
pp. 225-232 ◽  
Author(s):  
J.F. Marin ◽  
J. Boya
Keyword(s):  
Pituitary Gland ◽  
Postnatal Development ◽  
Ultrastructural Study ◽  
Interstitial Cells ◽  
Pars Intermedia ◽  
Palisade Cells

Participation of the intermediate lobe of the pituitary gland after prolonged exposure to unpredictable stress in the rat

1983 ◽  
Vol 99 (2) ◽  
pp. 239-243 ◽  
Author(s):  
Irina Pollard
Keyword(s):  
Pituitary Gland ◽  
Psychological Stress ◽  
Ultrastructural Study ◽  
Prolonged Exposure ◽  
Secretory Activity ◽  
Pars Intermedia ◽  
Intermediate Lobe ◽  
Cellular Activity ◽  
Stable Level ◽  
Circulating Levels

An ultrastructural study is described which relates cellular activity in the intermediate lobe of the pituitary gland with circulating levels of corticosterone. Exposure of male CSF rats to a signalled, unpredictable 60-day stress regimen induced intense secretory activity in all cells of the pars intermedia for the first 5 days of stressing, and thereafter secretory activity reverted back to the control condition. Blood corticosterone levels showed an initial extreme increase lasting for the first 5 days of exposure to the stress before gradually falling to re-establish a new stable level of secretion by 40 days. The possible involvement of the intermediate lobe in emotional or psychological stress when corticosterone levels are high is discussed.

The functional significance of glycosylation of proopiomelanocortin in melanotrophs of the mouse pituitary gland

1985 ◽  
Vol 107 (3) ◽  
pp. 365-374 ◽  
Author(s):  
B. G. Jenks ◽  
A. G. H. Ederveen ◽  
J. H. M. Feyen ◽  
A. P. van Overbeeke
Keyword(s):  
Pituitary Gland ◽  
Functional Significance ◽  
Peptide Hormones ◽  
Terminal Region ◽  
Pars Intermedia ◽  
Apparent Effect ◽  
Glycoprotein Precursor ◽  
Tunicamycin Treatment ◽  
Mouse Pituitary

ABSTRACT Pro-opiomelanocortin (POMC) is a glycoprotein precursor for a number of neuropeptides and peptide hormones. The functional significance of the glycosylation of POMC has never been established. Using the antibiotic tunicamycin to block glycosylation of the prohormone in the mouse pars intermedia, we have compared processing of non-glycosylated prohormone with that of glycosylated prohormone in pulse-chase experiments. The peptides produced from non-glycosylated prohormone were shown to be correct cleavage products. Therefore it was concluded that, with the possible exception of peptides from the N-terminal region of the prohormone, the carbohydrate on POMC plays no role in directing cleavage or in protecting the prohormone from random proteolysis. Tunicamycin treatment retarded N-terminal acetylation of melanotrophin but had no apparent effect on acetylation of β-endorphin. The mouse pars intermedia synthesizes two forms of POMC which differ in their degree of glycosylation. Our results indicated that, during secretion, the melanotrophs make no distinction between peptides derived from the two prohormones. J. Endocr. (1985) 107, 365–374

Late Embryonic and Postnatal Development of Interstitial Cells of Cajal in Mouse Esophagus: Distribution, Proliferation and Kit Dependence

2012 ◽  
Vol 196 (2) ◽  
pp. 175-188 ◽  
Author(s):  
Xiao He ◽  
Wen-cui Yang ◽  
Xiang-yin Wen ◽  
Di Tang ◽  
Lan Xiao ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Cells Of Cajal

A Pituitary Adenoma in a Zebra

1970 ◽  
Vol 7 (2) ◽  
pp. 186-189 ◽  
Author(s):  
G.A. Kennedy ◽  
G.S. Treviño
Keyword(s):  
Pituitary Adenoma ◽  
Pituitary Gland ◽  
Incidental Finding ◽  
Pars Intermedia ◽  
Equus Burchelli

An 8-year-old Grant's zebra ( Equus burchelli böhmi) that had died of pneumonia was found to have an adenoma of the pars intermedia of the pituitary gland, Klossiella equi were an incidental finding in the kidneys,

ADRENOCORTICOTROPHIC HORMONE IN THE ANTERIOR AND NEUROINTERMEDIATE LOBES OF THE FETAL RAT PITUITARY GLAND

1981 ◽  
Vol 89 (2) ◽  
pp. 181-186 ◽  
Author(s):  
ALAIN CHATELAIN ◽  
J. P. DUPOUY
Keyword(s):  
Pituitary Gland ◽  
Functional Differentiation ◽  
Pars Intermedia ◽  
Adrenocorticotrophic Hormone ◽  
Pars Distalis ◽  
Adult Rats ◽  
Adrenal Cells ◽  
Specific Radioimmunoassay ◽  
Fetal Rat ◽  
Rat Pituitary

The concentration of ACTH in the pars distalis and pars intermedia of the fetal rat hypophysis from days 17–21 of pregnancy was measured with a specific radioimmunoassay and a bioassay using isolated adrenal cells from adult rats. In both lobes of the pituitary gland, a significant correlation was observed between immunoreactive and bioreactive values, expressed as pg equivalents synthetic human 1–39 ACTH per μg protein. In the pars distalis, ACTH concentrations increased steadily from days 17–20 and then remained unchanged to term. At this time they were tenfold higher than on day 17. In the neurointermediate lobe, ACTH was detected only from day 18; the concentration of ACTH increasing between days 18 and 19. At each of the stages of pregnancy examined, the concentration of ACTH in the pars distalis was greater than that in the pars intermedia. These data have demonstrated that ACTH is present in both anterior and neurointermediate lobes of the fetal rat hypophysis, that the functional differentiation of the pars distalis takes place earlier than that of the pars intermedia, and that the concentrations of corticotrophin in the pars distalis and in the pars intermedia have different patterns of development as gestation progresses.

Immunocytochemical and ultrastructural study of the rat perireticular thalamic nucleus during postnatal development

1998 ◽  
Vol 392 (3) ◽  
pp. 390-401 ◽  
Author(s):  
Alida Amadeo ◽  
Silvia de Biasi ◽  
Carolina Frassoni ◽  
Barbara Ortino ◽  
Roberto Spreafico
Keyword(s):  
Postnatal Development ◽  
Ultrastructural Study ◽  
Thalamic Nucleus

AUFTRETEN VON KASTRATIONSZELLEN IM HYPOPHYSENVORDERLAPPEN MÄNNLICHER RATTEN NACH BEHANDLUNG MIT EINEM ANTIANDROGEN

1966 ◽  
Vol 53 (1) ◽  
pp. 53-60 ◽  
Author(s):  
F. Neumann
Keyword(s):  
Pituitary Gland ◽  
Inhibitory Effect ◽  
Anterior Lobe ◽  
Male Rats ◽  
Hormone Deficiency ◽  
Pars Intermedia ◽  
Sexual Hormone ◽  
Releasing Factors

ABSTRACT Following the administration of an androgen-antagonist (1,2α-methylene-6-chloro-pregna-4,6-diene-17α-ol-3,20-dione = cyproterone) to male rats, changes are observed in the anterior lobe of the pituitary gland comparable to those which develop following removal of the gonads. The appearance of so called castration cells is very striking, particularly in the periphery, and in the area adjacent to the pars intermedia. The findings suggest that the androgen-antagonism of cyproterone also manifests itself in those receptors of the sex centre, which regulate the amount of gonadotrophin production and secretion in relation to the production of testosterone. Since endogenous testosterone can no longer exert its inhibitory effect on the sex centre, the sex centre, as in a state of sexual hormone deficiency, reacts by secreting releasing factors for gonadotrophins. Thus those cell elements in the anterior lobe of the pituitary gland are stimulated and this leads to the production of gonadotrophin.

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